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Pramiracetam


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#61 Major Legend

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Posted 31 July 2012 - 05:26 PM

Ive found taking alpha gpc before sleep and in the morning helps with cognitive impairment damn i just bought the brain octane as well hopefully at such low doses its fine.

Seems like there is a possibility that there was a bad batch unfortunately nearlly all of what we buy are made in china and onky tested for purity every now and then i mean were kind of lucky no chinese manufacturer has majorly fucked up piracetam otherwise all of imminst will be brain dead

#62 MenDis

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Posted 11 August 2012 - 01:45 AM

I tried taurine for a couple of days at 1g each day and noticed mellower thinking - it definitely helps with avoiding the thought fragment attacks, but on the other hand it slowed my thinking and limited my abilities to spontaneously come up with thoughts. I also noticed that my heart seemed to be pumping harder - I could feel it beating in my chest. Not sure if that is a good thing blood pressure wise. Definitely not an every day supplement for me. I also dropped the ALCAR, which seemed to overstimulate my brain and now I don't have the thought fragment attacks anymore. Waiting to evaluate the effects of Uridine+DHA+choline and then I will look into Noopept and the other supps renfr has suggested.

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#63 canz

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Posted 11 August 2012 - 08:46 AM

Gthughes, L-theanine may have a lower side effect to benefit ratio for you at high doses than taurine, if in fact you need a higher dose. Lowers anxiety, increases mood and cognitive function. The cognitive improvement is enhanced with a small dose of caffeine (1:2) (ex. 50mg of caffeine to 100mg l-theanine). Recommended starting dose is 100mg twice daily with a max dose of 2g daily spaced into 5 doses.

http://www.ncbi.nlm....pubmed/21861094
http://www.ncbi.nlm....pubmed/19766184
http://www.ncbi.nlm....pubmed/18452993
http://www.ncbi.nlm....pubmed/18681988
http://www.ncbi.nlm....pubmed/18006208

Edited by canz, 11 August 2012 - 09:04 AM.


#64 Major Legend

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Posted 12 August 2012 - 10:48 PM

Tried pramiracetam, had similiar effects from 2 different brands so i'm assuming i'm taking the right stuff at about 100 to 200mg.

Responded badly with muscle weakness and heightened nervousness. Such a pity because it does seem to improve my recall, and makes me slightly smarter and i'm fascinated by these comments of becoming like an information sponge after a feel days, however the muscle weakness and cognitive damage (either an autoregulation issue in my brain or a form of unexplored depression), is a severe side effect i've only experienced once in my life very profoundly, and is something i dare not to revisit.
Makes me think that Pramiracetm is perhaps acting on more than one mechanism, whatever its triggering causing those symptoms in me is worrisome.

Moving onto Aniracetam, again nothing seems to rival the effects Piracetam has on me (which I no longer take on a daily basis due to tolerance issues). As I really need to learn a new skill or two, its frustrating that i haven't been able to find anything to improves my poor memory. (Piracetam improves my intelligence, but doesn't do much in terms of memory retention, something I need to study a new skill)

#65 aghonia

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Posted 02 July 2013 - 09:33 PM

Up: any news? I have 10g of Pramiracetam which I wish I never bought considering what I read there. I believe that it is good to maximize the diffusion of the information available in the current thread.

#66 ihsanozkan

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Posted 03 August 2013 - 07:01 PM

Yes I am also still using this within my daily stack. So do you have any news? Should I stop?

#67 aghonia

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Posted 04 August 2013 - 08:42 AM

Up: any news? I have 10g of Pramiracetam which I wish I never bought considering what I read there. I believe that it is good to maximize the diffusion of the information available in the current thread.


Considering that I didn't experience any remarkable positive effect, I stopped after 2 intakes. This makes sense, as I am a mild-responder to piracetam and pramiracetam (400mg) responders need also to be positively affected by piracetam. In my case, it produced the same bothering effects I got from an "overdose" of piracetam (4.8g) which implied light-mind and erratic though.

#68 MenDis

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Posted 22 May 2015 - 05:58 PM

I've seen some recent threads pop up here on longecity about people who have taken pramiracetam and I just want to provide an update on my situation as I really hope that what happened to me won't happen to anyone else. I took pramiracetam 4 years ago and I still have what seems to be significant brain damage that severely affects the quality of my life. While I remain optimistic that one day I will be able to fix it, everyday I struggle to continue to fight. I'll share a PM that I wrote someone last year who was contemplating taking it and unsure about it's safety:

 

Hi ---------,

Thanks for the message. Unfortunately I still struggle with major neurological issues from that incident. Most days I can't focus for more than 20 minutes at a time without experiencing a severe scrambling of my thoughts in addition to headache and nausea. I've seen over 20 different neurologists/psychiatrists and had several MRIs in addition to an MRA (angiogram) and EEG, all of which has not provided any more insight into my problem. The main problems that I have are:

-Severely impaired logical reasoning, comprehension, and working memory abilities. Oddly these functions are better when I write or talk.
-A persistent scrambling/fragmentation of my thoughts that makes my thoughts extremely shallow and jumpy. I can never think deeply about anything. This scrambling gets worse when I try to complete an analytical task and after trying to focus for 20 to 30 min, it gets bad enough to where I get a headache and get nauseous.
-Difficulty remembering/recalling previous actions and days. My long term memory has gotten progressively worse (probably as a result of impaired short-term memory).
-Difficulty planning
-Susceptibility to extreme stress from minor stressful situations. The elevated stress hormones seem to last for days. My recall and short-term memory are almost non-existent in these situations.
-Susceptibility to depression, psychotic thoughts, and extreme feelings of love. Difficulty attenuating emotional responses.
-Manic episodes that arise every once and a while from thinking too much about my situation and feeling like I am trapped in a mental prison.

As far as coming to a conclusion about what happened neurologically to me, I haven't been able to come to any definite conclusion due to a lack of available diagnostic technologies. I can only make hypotheses based on my symptoms and the studies that are available about pramiracetam. My hypothesis is that I caused damage to various areas of my cerebral cortex, with the most noticeable damage being to my left prefrontal cortex in the area responsible for logical, sequential thought (this would explain the thought scrambling and scattered/ADD component of my issues). As far as how pramiracetam caused this, I don't know. There is only a limited amount of information about it on pubmed and its mechanisms of actions remain largely unknown. Increased NO is certainly a candidate. Based on the reaction I had to it, it seems possible that it caused damage via excitotoxicity due to the scatteredness and overactivity that I seemed to be left with. Even now, three years later, the more I focus on something the faster and more scattered my thoughts become until I get nausea and a severe headache. This seems to indicate a prefrontal cortex overactivity to me, with the headache being from increased bloodflow and the nausea perhaps being from inflammation. But its hard to say.

I don't mean to sound dramatic, but taking pramiracetam/choline completely ruined my life. Before taking it, I graduated from a top university with a BS in Electrical Engineering with magna cum laude honors. I was working at a Defense Contractor doing electrical engineering while getting my Masters in Nanotechnology when this incident occurred. I was forced to quit my job as a result of the neurological issues that stemmed from taking these drugs and now I work in construction. It has been almost three years now since the incident and I have tried over 80 different supplements/drugs in an attempt to fix these issues. I have found some things that help significantly; bacopa seems to help significantly in conjunction with high levels of thyroid hormones (which can be obtained by taking ashwagandha and bacopa together). But the side effects (some potentially life-threatening) prevent it from being a long term solution. I have found other things that help, but nothing that brings me even close to the clarity, depth, and breadth of thoughts that I had before. I remain optimistic nonetheless that one day I will be able to fix these issues and continue to hunt everyday for the solution. In the meantime, I try to enjoy the things I can do; physical activities and social interactions always seem to help. 

Are you considering taking pramiracetam or have you taken it? My opinion (undoubtedly biased based on my experiences) is that there isn't enough information available on it to have any reasonable assurance of safety. And if you take it and it seems to open new mental doors for you (which it actually did for me a few times in college when I took it in smaller amounts), what will happen if you continue to take it? The studies are lacking and there are many other nootropics out there with more demonstrated efficacy and safety. But, of course, you are free to do as you wish and your mileage may vary. Please feel free to PM me if you have any other questions.

Best Wishes,
-------------

 

 



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#69 Coffeee

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Posted 09 February 2018 - 10:38 PM

yeah so my dick stopped working properly after taking pramiracetam...anyone know how to fix this?

 

Here is the quote i read from on this thread...it says it can AFFECT VASOPRESIN......finaly after 5 years of suffering i see it has affected my propyl endopeptidase!! how do i fix this!?

 

Pramiracetam is definetly not a very well researched nootropic. There are only about 3 studies involving human volunteers directly, two of which were pharmacokinetic studies. The remaining one shows that, in healthy volunteers, Pramiracetam partially reversed scopaline-induced amnesia (Arch Gerontol Geriatr. 1994 Mar-Apr;18(2):133-9). 

One of the studies in rats showed that Pramiracetam increased high affinity choline uptake into the hippocampus (Act Nerv Super (Praha). 1987 Mar;29(1):62-5). Another study found that pramiracetam and aniracetam inhibit propyl endopeptidase indicating a possible interaction with neuropeptides such as vasopressin or thyrotropin-releasing hormone. Aniracetam, however, was shown to be more potent than pramiracetam in this regard (J Pharmacobiodyn. 1987 Dec;10(12):730-5). 

So Pramiracetam is kind of in a grey area as far as safety and how it works (i.e. what differentiates it from the other structurally related racetams). The last study was published more than ten years ago, so it would seem that researchers find it of very little clinical usefulness in neurodegenerative pathologies. "
 
 





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