A patient unable to walk for the past 19 years due to a spinal injury takes steps after receiving stem cell therapy at the Shilla Hotel in Seoul, Korea.
http://times.hankook...17575710440.htm
Discussion:
http://carecure.atin...07393#868107393
Posted 28 November 2004 - 03:32 AM
Posted 28 November 2004 - 03:44 AM
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Posted 28 November 2004 - 08:31 PM
We now know that there are two main obstacles to regeneration after injury: inhibitors within myelin and the formation of a glial scar. The scar is formed by astrocytes, which change their morphology to present a physical barrier to growth and also upregulate several extracellular-matrix-associated inhibitors of regeneration. Before the scar matures, however, myelin seems to be the predominant source of growth inhibition.
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Three inhibitors of axonal regeneration have been identified in myelin – Nogo, myelin-associated glycoprotein (Mag) and oligodendrocyte myelin glycoprotein (Omgp). All of these proteins induce growth cone collapse and inhibit neurite outgrowth.
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Two approaches might be used to overcome inhibitors and encourage regeneration. First, the inhibitors and/or their receptors could be blocked with antibodies or peptides. Second, the intrinsic state of the neuron could be changed, such that it no longer recognizes the environment as inhibitory. Elevation of cyclic AMP inside the injured neuron has been shown to overcome inhibition by Mag and myelin.
Posted 28 November 2004 - 11:28 PM
Posted 29 November 2004 - 04:44 PM
Posted 29 November 2004 - 06:45 PM
Posted 29 November 2004 - 10:53 PM
I would have to agree about being skeptical. This identical method has been tried many times before with little success.
Posted 29 November 2004 - 11:08 PM
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Posted 27 November 2005 - 05:31 AM
Perhaps Bush's restrictive policy has gained us more than we think. If the US had taken a strong lead from the beginning, the Asians might never have found the courage to try and take the field. Due to the head start the Asians have got, and the investments they've made, they are compelled to keep fighting for the lead. Our bioconservative friends may have unwittingly kickstarted a competitive atmosphere here, which may pay off in terms of our goals in the long run.
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