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Vyvanse and nootropics?


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#1 Morpheus

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Posted 02 February 2011 - 05:12 AM


Hey Power Team,

Forgive me if this has been addressed elsewhere, I haven't found a direct (or supported) answer yet. I'm currently taking 50mg vyvanse for adult ADHD and It's been life changing. I take my pill in the AM sometimes with breakfast, sometimes without, and always with coffee. It seems like it's hit or miss as to whether I'm able to focus on any given day or not. My focus seems to come in waves, and unfortunately, the focus rarely comes in the afternoon. I'd like to know if anyone has any experience or knowledge on combining a nootropic/neuroprotectant/other to my daily vyvanse to increase its effectiveness, deflect those random bouts of panic, and improve cognitive health and function.

As a background:
I'm male, 22, 5'10 about 165lbs.
I take 4g of fish oil, 10k iu d3, and a multivitamin everyday.
I lift 3 times a week, generally heavy.
Sleep is decent, usually 7-8hrs a night.

Thanks for the help in advance!

#2 ultranaut

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Posted 02 February 2011 - 05:41 PM

That seems like a lot of D3 to me.
I find amphetamines to be better without caffeine most of the time. Magnesium at night seems to help. Piracetam seems to help quite a bit too.
Have you considered changing your dose or switching to a different form of dextroamphetamine? It might be beneficial to take a smaller dose when you first wake up and then a booster later in the day. I imagine dexedrine would make a better booster than vyvanse due to its typically shorter action and quicker onset.

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#3 Morpheus

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Posted 02 February 2011 - 07:08 PM

That seems like a lot of D3 to me.
I find amphetamines to be better without caffeine most of the time. Magnesium at night seems to help. Piracetam seems to help quite a bit too.
Have you considered changing your dose or switching to a different form of dextroamphetamine? It might be beneficial to take a smaller dose when you first wake up and then a booster later in the day. I imagine dexedrine would make a better booster than vyvanse due to its typically shorter action and quicker onset.


I do take a fair bit of d3, I’m doing this because it’s winter and I rarely get sun exposure (leave early, get home late). I find that caffeine is very beneficial regardless if I’m taking vyvanse or not. It seems to calm down my mind and allow me to focus, I just have to make sure to stop consumption before 5pm to avoid sleep trouble. You hit the nail on the head, I’ve been rx’d adderall IR to take in the afternoon, It should arrive in the next week.
I’ve heard mixing racetams and adhd meds is bad for you long term? Does anyone have any input on this?
I’ll look into the magnesium.

Any one have any other supplements that would be beneficial in my above mentioned medication protocol? I suppose I’m looking for something that will help keep my mood high, increase/ensure effectiveness of adhd meds, and ideally offer some neuroprotection as I assume long term vyvanse with an adderall booster probably isn’t awesome for your brain. If the additional supplements also had positive effects on memory that would be great!

Thanks for the reply ultranaut

#4 unregistered_user

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Posted 17 February 2011 - 08:29 PM

I too take Vyvanse and have taken Piracetam in the past. I am planning on combining the two. Any input or words of caution?

#5 startsomething

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Posted 26 March 2011 - 02:40 PM

I have been taking Vyvanse 60mg since January of 2009, and was just about to post on this same topic until I found this thread. I don't know how long you guys have been taking it but the only reason I even found my way to this forum and the subject of nootropics is because of my noticeable decline in memory and verbal fluency lately.

I didn't think much of it, or even consider that I might be having cognitive memory function problems until it got to the point that I would forget things my girlfriend would say from just a few hours earlier - or even in the same sentence.. and this was supposed to be on a strong dose of medication to make my ADD BETTER! My words just don't come out fluidly anymore, I forget them so often while talking that it frustrates me so much and I know can cause people to lose interest when I'm pausing and over-describing something when I can't think of the right word. I also knew I had to do something when I started noticing a lot more social inhibitions and being way less outgoing when I wasn't on Vyvanse, which bumps up those attributes 100 times.

So after some research, I think it's because of long-term use of Vyvanse. A quick search on Wikipedia on the subject shed some light on it, so I'm considering taking Synaptine Ultra to help combat these aggravating side effects. I don't wanna stop taking Vyvanse because it's been an absolute life changer, but at the cost of cognitive functions... so I want to try and balance things out a little more.

Morpheus- I will say this, I strongly recommend ALWAYS taking it on a full stomach. Your focus coming in waves and it being hit or miss, is 100% because of diet, I know this from experience. It's not gonna make it past lunchtime if you take it on an empty stomach, because without the natural boost from food to your body's amino acids it's a LOT less likely to re-enter your bloodstream and last as long. You're basically losing out on half its long-term potential. I know it's supposed to be 12 hour time-release, but trust me on this!

I also don't think taking it with coffee is generally a good idea, it could be the reason for your random bouts of panic. Amphetamines are strong stimulants, and caffeine is a stimulant as well, so you could be overdosing on stimulants. I'm now pretty much allergic to caffeine (I know, it SUCKS!) and used to have really bad anxiety for a while but ever since taking Vyvanse, anxiety is completely gone. Try taking it a couple hours after you've had coffee and see if that helps the panics (it'll also keep you alert a lot longer as opposed to all at once!)

How long have you guys been taking Vyvanse? I am admittedly a unique case.. I usually take Vyvanse in the middle of the day, late afternoon as opposed to first thing in the morning. I also have found a TON of ways to supplement it to prolong its effects during the day, PM me if you're interested.

Edited by startsomething, 26 March 2011 - 03:00 PM.


#6 unregistered_user

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Posted 26 March 2011 - 07:17 PM

I've stopped taking Vyvanse, maybe temporarily or maybe indefinitely, I haven't yet decided... in order to get back on a healthier regimen of supplements, vitamins and noots. This isn't due to any health concerns to undesirable effects. Actually, of all the ADHD medications I've tried I felt Vyvanse was the best tolerated, most effective and had the lowest side effect profile (for me).

Edited by semi-retarded-individual, 26 March 2011 - 07:18 PM.


#7 rvdvaart

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Posted 27 March 2011 - 06:58 AM

Hey Power Team,

Forgive me if this has been addressed elsewhere, I haven't found a direct (or supported) answer yet. I'm currently taking 50mg vyvanse for adult ADHD and It's been life changing. I take my pill in the AM sometimes with breakfast, sometimes without, and always with coffee. It seems like it's hit or miss as to whether I'm able to focus on any given day or not. My focus seems to come in waves, and unfortunately, the focus rarely comes in the afternoon. I'd like to know if anyone has any experience or knowledge on combining a nootropic/neuroprotectant/other to my daily vyvanse to increase its effectiveness, deflect those random bouts of panic, and improve cognitive health and function.

As a background:
I'm male, 22, 5'10 about 165lbs.
I take 4g of fish oil, 10k iu d3, and a multivitamin everyday.
I lift 3 times a week, generally heavy.
Sleep is decent, usually 7-8hrs a night.

Thanks for the help in advance!


Cut down the Vitamin D3 to about 5,000 IU a day and then lower it to 2,000 in the summer as you get more sun. Vitamin D toxicity can cause manic symptoms. Definitely DON'T take Piracetam with Vyvanse because it can cause neurotoxicity and manic symptoms. And don't take caffeine with Vyvanse because you will be way overstimulated. Amphetamines and caffeine are not a good combination.

For nootropics, you can try Ginko Biloba, Ashwagandha, Bacopa, and Vinop. I would also recommend supplementing a B-50 or B-100 complex because amphetamines quickly drain your body of B Vitamins. Green tea is also ok because it doesn't have much caffeine and it contains L-Theanine which calms your body down while giving you a certain amount of focus as well. It's also incredibly good for your body.

I've been on Prozac for about 6 months. I take Vyvanse on and off when I need it and it works well. Sometimes it can cause manic symptoms but I watch it pretty closely.

Edited by rvdvaart, 27 March 2011 - 07:04 AM.


#8 dilenja

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Posted 27 March 2011 - 07:52 AM

"Definitely DON'T take Piracetam with Vyvanse because it can cause neurotoxicity and manic symptoms. And don't take caffeine with Vyvanse because you will be way overstimulated. Amphetamines and caffeine are not a good combination."

I second this completely - the topic of amphetamines and racetams has been discussed extensively, the general consensus seems to be there are significant risks of excitotoxicity associated with this combination

#9 Gecko

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Posted 27 March 2011 - 04:22 PM

[i]"the topic of amphetamines and racetams has been discussed extensively, the general consensus seems to be there are significant risks of excitotoxicity associated with this combination


I may be missing something, but could someone point me to this discussion as I don't recall it and can't find it?

#10 dilenja

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Posted 28 March 2011 - 05:26 AM

[i]"the topic of amphetamines and racetams has been discussed extensively, the general consensus seems to be there are significant risks of excitotoxicity associated with this combination


I may be missing something, but could someone point me to this discussion as I don't recall it and can't find it?


Cheers: http://www.longecity...erallpiracetam/

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#11 unregistered_user

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Posted 29 March 2011 - 10:34 PM

Yea, Piracetam and amphetamines are a bad combination. I would steer clear.




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