6 replies to this topic

[oblomov]

Could anyone share their thoughts on DIM as a regular supplement? I haven't seen much discussion here on it.

From my reading, there appears to be significant evidence for it regular use from a hormonal regulation, anti-cancer, and immune support standpoint.

A key issue (much like other supps) is bioavailability. The two products that appear to circumvent this issue are Activamune and Bioresponse DIM.

I have taken both of them in the past. Activamune contains other substances in addition to DIM (such as lycopene, vit C, D3, E, etc), which I already get from other supps. So I currently take the Bioresponse product (which only contains some vit E-tocopheryl and phosphatidylcholine in addition to DIM).


Hormonal regulation:
http://www.ncbi.nlm....pubmed/21254914

Anticancer:
http://web.archive.o...anticancer.html
http://onlinelibrary...A73BB1D0.d03t04
http://www.mskcc.org.../html/92958.cfm
http://carcin.oxford...9/1659.abstract

Immune support:
http://www.activamun...data_center.htm

[thevaughny]

I'd like to hear some feedback as well. I am interested in trying it but I have read in some places that there may be concern with negative feedback loop which further reduces t for e to overcome the effects of the sup. That would start a bad cycle. But this comment that I know of wasn't based on fact it was just speculation.

[kilgoretrout]

I read all about the supposed powerful anti estrogen effects of DIM, so hoping it would steer my 25mg daily DHEA towards Test and away from Est., started taking a daily supplement of DIM.

However it had the opposite of the purported effect... libido, erectile function, orgasm strength, ejaculate volume all dropped to barely above zero. Quite distressing. After I quit the DIM things returned to where they had been before in about a week, and then I quit the DHEA also and Libido etc. seemed to get even better, so apparently I was just increasing my Estrogen levels all along with the DHEA. I guess its a bad idea for men to use it without a highly potent arromatase inhibitor, which apparently DIM is *NOT*, though stuff I read claimed it was a very strong one.

I have no theoretical clue why DIM had this apparently opposite-from expectations effect in me but it did. I later did a search and found other men who said it also killed their sex drive libido and performance as well.

Very wierd discombobulating stuff... dont believe all the promotional puffery, apparetnly its all bullshit... stay away!

[resveratrol]

I read all about the supposed powerful anti estrogen effects of DIM, so hoping it would steer my 25mg daily DHEA towards Test and away from Est., started taking a daily supplement of DIM.

However it had the opposite of the purported effect... libido, erectile function, orgasm strength, ejaculate volume all dropped to barely above zero. Quite distressing. After I quit the DIM things returned to where they had been before in about a week, and then I quit the DHEA also and Libido etc. seemed to get even better, so apparently I was just increasing my Estrogen levels all along with the DHEA. I guess its a bad idea for men to use it without a highly potent arromatase inhibitor, which apparently DIM is *NOT*, though stuff I read claimed it was a very strong one.

I have no theoretical clue why DIM had this apparently opposite-from expectations effect in me but it did. I later did a search and found other men who said it also killed their sex drive libido and performance as well.

Very wierd discombobulating stuff... dont believe all the promotional puffery, apparetnly its all bullshit... stay away!

Very interesting! It was prescribed to me when I began testosterone supplementation about a year ago. However, all my blood testing found extremely low levels of testosterone, despite my being quite healthy and having a healthy libido, and the testosterone supplementation did nothing and I eventually quit.

So if DIM supplementation somehow backfired, that would explain a lot of what happened.

[markymark]

snip

I would suggest to take a gender effect into account here, i. e. if DIM (and a precursor I3C) brings about negative effects on sexdrive and performance in men, this should be taken as serious observation so far. Although, more case reports and studies are needed (needless to say)
However, in antiaging medicine we use these cruciferous phytochemicals (I3C and DIM) to modify certain estrogen metabolites in females under hormone replacement therapy towards a favourable 2OH-E1/16OH-E1 ratio in urine. I have have never heard negative effe
cxts on sexlife in females under I3C/DIM for preventive means (breast cancer)

I3C is included in Bioforge from Biotivia together with Icariin and Forskolin... Hm the stuff is still selling

regs
MM

[zm3thod]

I have some experience with DIM. Over the past couple of years, there have been periods where I've taken 100-200mg a day with bioperine. I noticed none of the aforementioned negative side effects. One thing that was apparent was that it helped clear up the skin on my face, less acne and smoother/healthier looking skin. Enough of an improvement that my girlfriend asked what I had changed lately

Personally I don't see enough information on DIM to take it regularly. I was drawn to it because of the anti-cancer and purported abilities to deal with "bad estrogens" (xenoestrogens like BPA, pthlalates and others)

[DeadMeat]

I read all about the supposed powerful anti estrogen effects of DIM, so hoping it would steer my 25mg daily DHEA towards Test and away from Est., started taking a daily supplement of DIM.

However it had the opposite of the purported effect... libido, erectile function, orgasm strength, ejaculate volume all dropped to barely above zero. Quite distressing. After I quit the DIM things returned to where they had been before in about a week, and then I quit the DHEA also and Libido etc. seemed to get even better, so apparently I was just increasing my Estrogen levels all along with the DHEA. I guess its a bad idea for men to use it without a highly potent arromatase inhibitor, which apparently DIM is *NOT*, though stuff I read claimed it was a very strong one.

I have no theoretical clue why DIM had this apparently opposite-from expectations effect in me but it did. I later did a search and found other men who said it also killed their sex drive libido and performance as well.

Very wierd discombobulating stuff... dont believe all the promotional puffery, apparetnly its all bullshit... stay away!

DIM is an anti androgen in the sense of blocking the receptors and I assume thereby the effects of testosterone and family. So maybe that effect can be stronger than its anti aromatase effects in some people. It's anti cancer effects look interesting though.
http://en.wikipedia....ki/Antiandrogen
http://www.ncbi.nlm....pubmed/12665522