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Thoughts on Wellbutrin?


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#61 Valor5

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Posted 27 March 2012 - 12:43 AM

Yeah, alive, close to doing well.

This neurotoxicity, does it creep up on you? would I be experiencing headaches or brain fog or anything out of the ordinary if something was going wrong?


Well, dopamine is naturally neurotoxic. For some reason, it is that way. So, that threat is always present regardless of even medications. MAOi's I believe can help that. Even reuptake inhibitors can help that. The other problem would be anything damaging the DNA of the mitochondria. So, as far as symptomatology or anything like that, I would watch for the worst symptoms and anything that causes unbearable dysfunction. There is no test that I know of for neurotoxicity or mtDNA damage or damage to neurotrophic factors and there are people who take this stuff for many years. I think as long as your neurotrophic factors are working good there should not be too much to worry about but science I don't think can figure even when that stops working or if it is working properly. So, I guess the best thing to do is take the best antioxidants and be vigilant for the worst side effects. I don't know if your brain replaces damaged cells in all parts of the brain or if it is just in certain areas. If it is all then the ones bupropion damages will be replaced and you have nothing to worry about and if they cannot be replaced then you would certainly have something to worry about. Chemicals found in nature via plants or herbs come in variety and quantity whether that is for the plants benefit or the benefit of the consumer you will have to decide. I believe it is for the benefit of the consumer. Professor Youdim who I think helped to make rasagiline thinks that drugs should come in chemical packages like they do in plants because often times one chemical is just not enough.

#62 chroncile

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Posted 27 March 2012 - 02:00 AM

Yeah, alive, close to doing well.

This neurotoxicity, does it creep up on you? would I be experiencing headaches or brain fog or anything out of the ordinary if something was going wrong?


Well, dopamine is naturally neurotoxic. For some reason, it is that way. So, that threat is always present regardless of even medications. MAOi's I believe can help that. Even reuptake inhibitors can help that.


Dopamine itself is not neurotoxic so I don't know where you got that information from, but dopamine's metabolites are neurotoxic. Maybe you were confusing the two.

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#63 Valor5

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Posted 27 March 2012 - 03:57 PM

Yeah, alive, close to doing well.

This neurotoxicity, does it creep up on you? would I be experiencing headaches or brain fog or anything out of the ordinary if something was going wrong?


Well, dopamine is naturally neurotoxic. For some reason, it is that way. So, that threat is always present regardless of even medications. MAOi's I believe can help that. Even reuptake inhibitors can help that.


Dopamine itself is not neurotoxic so I don't know where you got that information from, but dopamine's metabolites are neurotoxic. Maybe you were confusing the two.


Well I am glad you are asking for the reference. Perhaps you are right but I got that impression from studies I briefly went over. I will have to go through all the stuff I have been looking at and hopefully I will be able to see why I made that assertion.

#64 Clem

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Posted 27 March 2012 - 08:02 PM

It's been a number of years since I was on Wellbutrin. I loved what it did for my mood, but for me one of the side effects was TERRIBLE cotton-mouth. I do a lot of presentations for work and I found that while on Wellbutrin that I had to take a sip of water after almost every sentence I spoke.

#65 longevitynow

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Posted 27 March 2012 - 08:57 PM

As I mentioned before, Wellbutrin can have an effect in one dose and that can improve mood afterwards. To enhance this effect, break or chew the pill into little pieces. You will get a lot more dopamine in your system quickly. The person will feel more alive that day, but also likely for days afterwards as they have been so low in dopamine for so long that a single dose reminds them/gives them the experience of having a lot of dopamine in their system. Especially good for burnout or lethargic depression. I use a single dose of deprenyl occasionally (1x month) for a similar effect. Daily dosing and the salience disappears.

#66 Valor5

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Posted 27 March 2012 - 10:11 PM

Bupropion has a relationship with nitric oxide. Methylene blue potentiates bupropion because in inhibits nitric oxide synthase. Nitric oxide and bupropion killed the sh-sy5y cells in the neurotoxic study mentioned above. I think this is because of the nitric oxide.

Edited by valory5, 27 March 2012 - 10:40 PM.


#67 Valor5

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Posted 31 March 2012 - 12:58 PM

I took some propolis and methylene blue with my bupropion and they completely destroyed the effects of bupropion. Propolis I later discovered activates or connects to estrogen receptors or is estrogenic and I took a bunch of propolis and both these things inhibit NO so the end result was that I felt fine even around people no anxiety or depression but the libido effects where not there and having an erection seemed impossible so at least I know the bee propolis works and the MB. I had a small headache almost not really worth mentioning but I have a low blood pressure so perhaps someone with a higher blood pressure would experience more of a headache.I also tried some PEA (phenylethylamine) a day later and had little effect. Trying to figure that one out.Peace.

Edited by valory5, 31 March 2012 - 01:08 PM.


#68 Valor5

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Posted 14 April 2012 - 12:29 AM

I think the bupropiocrap gave me tinnitus. I have a high pitch buzzing sound in my ears. There are a lot of drugs that will mess up your hearing. Be careful. Search ototoxicity, tinnitus, deafness, hearing loss, etc.

#69 chroncile

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Posted 14 April 2012 - 12:52 AM

Bupropion is not ototoxic and will not mess up your hearing. If you find any studies that found bupropion to be ototoxic or that found bupropion to cause hearing loss then please post them on here.

#70 Valor5

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Posted 14 April 2012 - 07:58 AM

Bupropion is not ototoxic and will not mess up your hearing. If you find any studies that found bupropion to be ototoxic or that found bupropion to cause hearing loss then please post them on here.


http://www.crazyboar...ng-ototoxicity/
http://www.purdue.ed...otoxicguide.pdf
http://www.chchearin...ic_Brochure.pdf



#71 Valor5

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Posted 14 April 2012 - 08:12 AM

Here are some more before my battery runs out.

http://books.google....ved=0CDAQ6AEwAQ

http://m.youtube.com...JtufZPsQ8&gl=US

http://stason.org/TU...oxic-drugs.html




#72 Here2Learn

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Posted 14 April 2012 - 03:10 PM

I have recently started Wellbutrin for depression and as part of a plan through my pain management Dr to eliminate a longterm dependency on heavy opiates. (80-160 mg oxycontin & 20-60 mg hydrocodone daily for past 5 years) Opiates take their toll on neurotransmitter production.

So far I haven't experienced any negative side effects from the Wellbutrin in the short term but I'm aware there are some potential long term effects on the brain. The long term is what I'm worried about. My aim is to heal my brain, not damage it further. Are there any good countermeasures against Wellbutrins possible long term negative effects on the brain?

Are there any possible negative interactions with my other medication or daily supplement regimen and the Wellbutrin?
I am currently taking:
300mg Wellbutrin XL (11:00 am)
8-16 mg suboxone (4-8 mg 2x daily 9am / 9pm)
4grams mixed fatty acids (with meals)
Prebiotic/Probiotic blend & HSO Probiotic
1500 mg magnesium chloride/200mg elemental mgnsm
150mg CoQ-10, 100mg Ubiquinol
Vit C, B Complex, Vit D
Every night before bed (between midnight & 3am) I alternate between taking a blend of valerian, lemon balm, l-theanine, hops extract, chamomile, melatonin or 200 mg 5-htp, 500 mg l-tyrosine, 500 mg dlpa

Thank You

Edited by Here2Learn, 14 April 2012 - 03:11 PM.


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#73 chroncile

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Posted 17 April 2012 - 11:12 PM

Valory5, none of the links you posted said anything about hearing loss. "Ototoxicity is damage to the hearing or balance functions of the ear by drugs or chemicals.". That's the definition of ototoxicity. The links you provided only mentioned tinnitus, but did not mention any damage or hearing loss and I would be surprised if doctors were prescribing it knowing it can cause damage to hearing.




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