Posted 31 March 2011 - 07:36 PM
Modafinil should work fine with venlafaxine. While modafinil's DRI properties are pretty weak, it and other (stronger) DRI's such as Focalin are safe with effexor as long as you don't take crazy high doses.
It does improve cognition even in non-fatigued people, but the effects are pretty mild. That's probably why Imagination said there are no cognitive benefits; you wouldn't notice them unless you were taking a neuropsychological test.
But, like he also said, your cognition WILL be improved if you're fatigued. Modafinil effectively counters the fatigue and lethargy of depression, but you shouldn't use it for this every day. Tolerance develops rapidly. Save it for times when you need it.
It doesn't usually give people anxiety, but I don't think it's been tested in people with anxiety disorders. Like any stimulant, it could aggravate pre-existing anxiety.
You could try picamilon to prevent aggravation of the anxiety; at low doses it's a non-sedating anxiolytic and at higher doses it also has a mild stimulating effect while still preventing anxiety. But check the supplier threads around here -- there seems to be a lot of fake picamilon out there, which leads a lot of people to say that picamilon does nothing. Also, some people just don't respond even to genuine picamilon at any dose. So it could be worth a try, but it's up to you to decide if it's worth pursuing.