37 replies to this topic

[Darkat]

I do recollect reading that aniracetam had been withdrawn from the Japanese market due to a negative animal study.

Does this have any relation to nefiracetam and it's breakdown metabolites in dogs? Both aniracetam and nefiracetam are similar in structure.

It would be interesting to see more details of this Japanese study - I can't seem to find much on the net. With nefiracetam it would seem that the metabolite M18 predominates in dogs and this causes the toxicity symptoms. General consensus is that it is ok in humans at less than 30mg/kg along with taking regular breaks from using it.

Has anyone seen similar studies for aniracetam?

[golden1]

I've never been able to find that study or ever seen a link or excerpt posted anywjere

[kevinseven11]

You may want to add a gaba antagonist along with your aniracetam if you don't want long term anxiety. http://www.neurobrai...k-for-some.html
My post also says you may want an adrenal support supplment.

[Darkat]

I was under the impression that GABA antagonists can cause seizures?

Supporting the adrenals is always a good idea - many adaptogenic herbs can be useful for this, along with pregnenolone and dhea.

Edited by Darkat, 16 December 2012 - 09:37 AM.

[kevinseven11]

They can but only in dangerous doses or if you are prone to them. Bacopa prevents seizures through unknown mechanisms so combine that with a gaba antagonist.

[stablemind]

Alright so this is my third time using this and I notice a subtle but significant improvement in my processing abilities. My thoughts flow much more smoothly and I don't suddenly go off in a tangent because I lost track of my thoughts. I took ALCAR this time and I'm sure it offsetted the lethargy that the Aniracetam was causing.

I'm Dxed Bipolar II for anyone with mood disorders concerned. Thankfully I have not experienced any hypomania as of yet, although I do notice a mild elevation in mood. I'll continue testing and report back.

[jumbobrown]

I'm reading people say too much Choline will increase depression and someone else says they stay low and only take 100mg a day. If 1 Large Egg has 126 mg then you're saying eating 3 eggs a day, even boiled will possibly increase depression?

[peakplasma]

I'm reading people say too much Choline will increase depression and someone else says they stay low and only take 100mg a day. If 1 Large Egg has 126 mg then you're saying eating 3 eggs a day, even boiled will possibly increase depression?

Not likely that 3 eggs a day will cause depression. It will vary depending on the individual and their diet.

Choline is an essential nutrient so you need it from your diet; rather it is excess choline that is a problem.

I think its hard to have excess choline from diet but supplementing large amounts with it would be a concern.