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Propentofylline for Humans


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#1 thedevinroy

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Posted 27 June 2011 - 09:02 PM


Propentofylline (Vivitonin) is currently prescribed to pep-up old dogs. It's basically coffee for dogs. It's a xanthine derivative (like caffeine) with neuroprotective effects.

Vivitonin is given to elderly dogs to help reduce any problems with their hearing, sight, mental or physical condition. It works by increasing oxygenation, neurological and cardiovascular function, and helping to reduce the severity of aging symptoms such as tiredness, apathy, lethargy, senility, stiff gait, troubles standing or walking, wasting, alopecia. It also increases dogs' appetite and energy levels, whilst restoring more shine to their dull coat.


When looking it up on Wiki, it is described as a nonselective phosphodiesterase inhibitor (PDEI) and an adenosine reuptake inhibitor (AdoRI). It's also being researched as a treatment for Alzheimer's disease, multi-infarct dementia, and ischemic stroke (due to its vasodilating properties).

Apart from eating out of the dog bowl like a toddler or husky cat, would it be wrong to buy some and try it myself?

#2 marbleowen

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Posted 01 July 2011 - 12:09 AM

dude, just drink more coffee haha. I guess who am I to judge as I'm experimenting with L-Dopa, but it's just kinda junky to take dog pills. It would be kinda cool to go and tell the vet your dog needs some of this junk and then take it yourself though.

I guess the benefit over coffee would be that you hopefully you don't get coffee anxiety?
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#3 FadingGlow

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Posted 01 July 2011 - 02:36 AM

dude, just drink more coffee haha. I guess who am I to judge as I'm experimenting with L-Dopa, but it's just kinda junky to take dog pills. It would be kinda cool to go and tell the vet your dog needs some of this junk and then take it yourself though.

I guess the benefit over coffee would be that you hopefully you don't get coffee anxiety?


This is a sort of close minded response... Just because they found it can service dogs before anything else doesn't mean it has no usage...not that it does either, I guess that's to be determined.

#4 The Human Meteorite

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Posted 01 July 2011 - 05:28 AM

I find it strange that an adenosine reuptake inhibitor would increase subjective energy levels. It seems like their may be another aspect to it's pharmacodynamic profile not yet discovered. As it is understood now, caffeine and a vasodilator (my favorite is xanthinol nicotinate) would probably be better.

#5 thedevinroy

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Posted 01 July 2011 - 05:16 PM

I don't think it would be worth it to try it... I just found the results of a study showing that it failed as a treatment for Alzheimer's. Not that I have a degenerative disorder, but I guess I was hoping for more "added benefits" for humans. For a general neuroprotective vasodilator, it would probably still work.

In regards to it being an adenosine reuptake inhibitor, perhaps it has a high affinity for the transporters to the blood vessels rather than to the heart tissues. In dogs, it may be overpowered by its PDE inhibiting properties... which actually increases cAMP and cGMP. It's a downer and an upper at the same time. I think dogs have a more stimulating effect because they are much more sensitive to xanthines probably for their adenosinergic properties.

#6 Cephalon

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Posted 28 May 2012 - 10:46 PM

I don't think it would be worth it to try it... I just found the results of a study showing that it failed as a treatment for Alzheimer's. Not that I have a degenerative disorder, but I guess I was hoping for more "added benefits" for humans. For a general neuroprotective vasodilator, it would probably still work.

In regards to it being an adenosine reuptake inhibitor, perhaps it has a high affinity for the transporters to the blood vessels rather than to the heart tissues. In dogs, it may be overpowered by its PDE inhibiting properties... which actually increases cAMP and cGMP. It's a downer and an upper at the same time. I think dogs have a more stimulating effect because they are much more sensitive to xanthines probably for their adenosinergic properties.


Did you actually try this? My dog is on it - she is 13 years and has slight dementia - after a couple weeks on it she appears to be alot sharper. I'm a bit afraid of trying it though without any first hand reports.

Anyone tried this? It's an over the counter pet medicine (OTC in Germany)

Edited by Cephalon, 28 May 2012 - 10:47 PM.


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#7 nowayout

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Posted 29 May 2012 - 11:08 PM

I have been on pentoxifyllene in the past, a very closely related drug used in humans. Also a PDEI and AdoRI. I was on it for an autoimmune condition (it inhibits TNF and other cytokines) for a while.

If you have chronic low-grade inflammation, it may be helpful for that.

I didn't feel any stimulant effect from it.




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