What impressed me about this study is how the used the word "Anabolic" to describe the level of GAG synthesis produced. It doesn't state which type of vitamin K was used or dose. Instead of supplementing with Glucosamine, chondroitin and HA, perhaps all we need is more vitamin K ? Anyways, this lends more support against the low fat mantra and for eating butter which is rich in vitamin K (mk-4). It can also explain why some people report skin benefits from supplementing vitamin K
[The role of vitamin K in the metabolism of connective tissue biopolymers (review)].
[Article in Russian]Sharaev PN.
Abstract
Metabolism of connective tissue biopolymers was studied under conditions of various content of vitamin K in the body. The data obtained suggest the existence of a new metabolic effect of vitamin K--its participation as an allosteric activator in regulation of glucosamine synthetase (EC 5.3.1.19). The anabolic effect of vitamin K on connective tissue is apparently related to an increase in the rate of biosynthesis of glucosamine-6-phosphate--general precursor of glycosaminoglycans, glycoproteins and hexosamine-containing glycolipids.
PMID:6369774
