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Paleo, Evolution,& Vegetarianism -- Split from "High LDL Cholesterol and Amyloid Plaques"


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#1 inkyoto

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Posted 22 November 2011 - 08:07 AM


Sorry vegetarians. You were evolved to eat meat, just like cats and dogs.


Maybe you were evolved, but I have evolved, and there are no signs the evolution in humans has completely stopped, although there have been some notes that it has somewhat slowed down. Your argument is in the same ballpark as "where do you vegetarians get your protein from".

I do not dispute your choice to prefer meat, as you would not normally dispute the eating habits of the others. Thanks to subtle differences in the personal genetic makeup, some people naturally can't be vegetarians, the same is true in the inverse direction, too. There is no conclusive evidence, which of the two, meat or veggies, is ultimately healthy and leads to immortality. Most likely, none. Some thrive on eating meat, whilst the others - not so; the opposite is also true. As someone who supplements your meat diet with a sizable stack of supplements, you can't assert that what you perceive as the benefits of your meat rich diet alone is purely because of your diet. Besides, if a meat eater can supplement, why a vegetarian can't. It is true, though, that many vegetarians live off health detrimental diets rich in grains/simple carbs and deprived of other things vital, e.g. the right fats.

The bottom line, I think, is that any diet has to be carefully composed for that particular person in question and has to take into consideration variations in the genetic makeup. The diet that is good for me might not necessarily be good for you, and the other way around. I define "good" as in having good biological markers that come out of the annual blood test, plus the perception of the general well-being.
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#2 DukeNukem

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Posted 22 November 2011 - 11:59 PM

Sorry vegetarians. You were evolved to eat meat, just like cats and dogs.


Maybe you were evolved, but I have evolved, and there are no signs the evolution in humans has completely stopped, although there have been some notes that it has somewhat slowed down. Your argument is in the same ballpark as "where do you vegetarians get your protein from".

I do not dispute your choice to prefer meat, as you would not normally dispute the eating habits of the others. Thanks to subtle differences in the personal genetic makeup, some people naturally can't be vegetarians, the same is true in the inverse direction, too. There is no conclusive evidence, which of the two, meat or veggies, is ultimately healthy and leads to immortality. Most likely, none. Some thrive on eating meat, whilst the others - not so; the opposite is also true. As someone who supplements your meat diet with a sizable stack of supplements, you can't assert that what you perceive as the benefits of your meat rich diet alone is purely because of your diet. Besides, if a meat eater can supplement, why a vegetarian can't. It is true, though, that many vegetarians live off health detrimental diets rich in grains/simple carbs and deprived of other things vital, e.g. the right fats.

The bottom line, I think, is that any diet has to be carefully composed for that particular person in question and has to take into consideration variations in the genetic makeup. The diet that is good for me might not necessarily be good for you, and the other way around. I define "good" as in having good biological markers that come out of the annual blood test, plus the perception of the general well-being.


Evolution would not have adjusted to people becoming vegetarians in the last 10,000 years. And, all indications/research shows that a vegetarian diet is less healthy than a paleo-style diet. Quite simply, carbs = sugar, and sugar is a pro-aging "nutrient". It creates more metabolic waste than fatty acids, and creates more glycation issues.

One of the most important and revealing commonalities in people living post-100 is that they have low fasting insulin levels, which generally means they have not had a carb-rich diet -- in fact, none are vegetarians.

Humans became human thanks to energy- and nutrient-rich animal-source foods, especially highly fatty, nutrient-soaked organ tissues. Pre-agricultural humans and our recent hominid ancestors greatly preferred fatty organ means, like livers, brains, bone marrow, versus muscle meats, which were seen as far less important to eat and probably handed down to the least important people in a tribe.

To choose to eat a vegetarian diet now goes against your genetic coding. This is why babies die when only fed a vegetarian diet.

Now that vegetarianism has been around as a fad for 20+ years, there are several recent books from long-time vegetarian practitioners who've come back to eating meat because their health couldn't take it anymore. An example is, The Vegetarian Myth.

The fats especially, in plant foods, are inflammatory to humans, and are pro-aging to our cells. Meanwhile, saturated fat, which doesn't oxidize (which is why it doesn't need to by hydrogenated or kept in the fridge) is extremely stable in our body, and also used as a clean-burning fuel source.

There are no humans that can survive on a non-supplemented vegetarian diet for anywhere close to their full lifetime. And those who try, pay a price.
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#3 scottknl

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Posted 23 November 2011 - 05:46 AM

Having come back from the CR Society conference last month, I have to say that all were healthy, including vegetarians and meat eaters too. I'm starting to think that a carefully planned diet is much more important than the choice of your protein. It's pretty silly to imply that you can't be healthy on a vegetarian diet. Where does it say in the rule book of life that you can't take advantage of supplementation? If I can take advantage of any advance to make my life longer and healthier, it makes sense to do so. Are you in some kind of post apocalypse fantasy world where you can never buy a B12 supplement? Are you suggesting that we all have to eat only what our ancestors ate in order to have good health? What a silly thing that would be. We have access to foods from around the world that our ancestors never had access to and can create diets from combinations of these foods that no populations have tested before.

The Vegetarian Myth is a good example of going from one stupid diet to another. If you listen to the you tube interviews of the author, you'll know right away why she got sick. The real path to health thru diet isn't to change to be a vegan, vegetarian or meat eater. It's to pay careful attention to what and how much you eat. Healthy diets don't happen by accident whether vegetarian or meat eating.

As for thinking you're healthy with 235 cholesterol, heh, well I'm pretty sure you won't last as long as comparably aged CRON folks that have better balanced lipid profiles. That level of serum fat cruising around in your blood is just asking for ROS damage to occur.

Christian Mortensen followed a vegetarian diet and lived to 115+. Don't know if he supplemented.

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#4 Sillewater

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Posted 23 November 2011 - 07:11 AM

I can see where Duke is coming from, I used to think all that, but the more I read and analyzed the more I skew towards a vegetarian diet.

Edited by Sillewater, 23 November 2011 - 07:12 AM.


#5 DukeNukem

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Posted 23 November 2011 - 07:11 PM

Having come back from the CR Society conference last month, I have to say that all were healthy, including vegetarians and meat eaters too. I'm starting to think that a carefully planned diet is much more important than the choice of your protein. It's pretty silly to imply that you can't be healthy on a vegetarian diet. Where does it say in the rule book of life that you can't take advantage of supplementation? If I can take advantage of any advance to make my life longer and healthier, it makes sense to do so. Are you in some kind of post apocalypse fantasy world where you can never buy a B12 supplement? Are you suggesting that we all have to eat only what our ancestors ate in order to have good health? What a silly thing that would be. We have access to foods from around the world that our ancestors never had access to and can create diets from combinations of these foods that no populations have tested before.

The Vegetarian Myth is a good example of going from one stupid diet to another. If you listen to the you tube interviews of the author, you'll know right away why she got sick. The real path to health thru diet isn't to change to be a vegan, vegetarian or meat eater. It's to pay careful attention to what and how much you eat. Healthy diets don't happen by accident whether vegetarian or meat eating.

As for thinking you're healthy with 235 cholesterol, heh, well I'm pretty sure you won't last as long as comparably aged CRON folks that have better balanced lipid profiles. That level of serum fat cruising around in your blood is just asking for ROS damage to occur.

Christian Mortensen followed a vegetarian diet and lived to 115+. Don't know if he supplemented.


A CR diet can hide the fact that the diet is not optimal. Most CRer's I know eat a diet that leaves a lot of health gains on the table, by still eating grains, fructose, and plant oils, and not eating enough animal proteins/fats. They are definitely getting health gains, but they're not maximizing their efforts by choosing a poor diet. A vegetarian diet IS a sub-optimal diet.
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#6 scottknl

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Posted 24 November 2011 - 03:39 AM

There's no evidence that what you call an optimal diet extends maximum lifespan. Seems like you have lots of wishful thinking going on. Do people who don't eat grains, like the Inuit in Canada, live extra long lives? No, not today and not 100 years ago before their diets changed for the worse.. Okinawan elders eat lots of fruit, yet live extra long and healthy lives, so that one is blown right there.

On the other hand CR has lots of good looking evidence (some even in humans GASP!) and more accumulates each year. It's a shame you don't know many people doing a healthy CRON diet. You might learn something important from them.
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#7 DukeNukem

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Posted 24 November 2011 - 06:52 AM

There's no evidence that what you call an optimal diet extends maximum lifespan. Seems like you have lots of wishful thinking going on. Do people who don't eat grains, like the Inuit in Canada, live extra long lives? No, not today and not 100 years ago before their diets changed for the worse.. Okinawan elders eat lots of fruit, yet live extra long and healthy lives, so that one is blown right there.

On the other hand CR has lots of good looking evidence (some even in humans GASP!) and more accumulates each year. It's a shame you don't know many people doing a healthy CRON diet. You might learn something important from them.


The Inuit might not live longer on average, but they certainly live healthier on average.

The Okinawan eat a CR diet, plus is a paleo-style diet with a lot more meats than most "experts" realize. I've talked about this in previous posts, so I won't repeat myself. Here's a quick rundown, though:
http://drbganimalpha...-fat-diets.html

The best CRON would be PCRON, or Paleo-CRON. But I do not know of any CRONer eating paleo-style. And thus, they eat sub-optimal diets.
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#8 inkyoto

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Posted 24 November 2011 - 03:01 PM

Sorry vegetarians. You were evolved to eat meat, just like cats and dogs.


Maybe you were evolved, but I have evolved, and there are no signs the evolution in humans has completely stopped, although there have been some notes that it has somewhat slowed down. Your argument is in the same ballpark as "where do you vegetarians get your protein from".

I do not dispute your choice to prefer meat, as you would not normally dispute the eating habits of the others. Thanks to subtle differences in the personal genetic makeup, some people naturally can't be vegetarians, the same is true in the inverse direction, too. There is no conclusive evidence, which of the two, meat or veggies, is ultimately healthy and leads to immortality. Most likely, none. Some thrive on eating meat, whilst the others - not so; the opposite is also true. As someone who supplements your meat diet with a sizable stack of supplements, you can't assert that what you perceive as the benefits of your meat rich diet alone is purely because of your diet. Besides, if a meat eater can supplement, why a vegetarian can't. It is true, though, that many vegetarians live off health detrimental diets rich in grains/simple carbs and deprived of other things vital, e.g. the right fats.

The bottom line, I think, is that any diet has to be carefully composed for that particular person in question and has to take into consideration variations in the genetic makeup. The diet that is good for me might not necessarily be good for you, and the other way around. I define "good" as in having good biological markers that come out of the annual blood test, plus the perception of the general well-being.


Evolution would not have adjusted to people becoming vegetarians in the last 10,000 years. And, all indications/research shows that a vegetarian diet is less healthy than a paleo-style diet. Quite simply, carbs = sugar, and sugar is a pro-aging "nutrient". It creates more metabolic waste than fatty acids, and creates more glycation issues.


The evolution is an ongoing process, and a 10000 year span is barely enough to assert the results of it.

An excess of fast and nutritionally void carbs is a big issue, this is something I agree with you wholeheartedly. However, no-one forces me eat carbs, it is me who decides what I am going to eat and what I am not going to eat.

Also, if glycation is the main issue with the vegetarian diet, what is the main reason you supplement your paleo style diet with a stack of antiglycation supplements? Is there anything you are particularly worried about?

One of the most important and revealing commonalities in people living post-100 is that they have low fasting insulin levels, which generally means they have not had a carb-rich diet -- in fact, none are vegetarians.


There exist no statistically important examples of any modern population, members of which have repeatedly reached 100+ life spans living purely off a paleo style diet. Please correct me otherwise.

1) A topic, beaten around here to death, of Okinawans, is quite revealing in that that their daily diet is mostly composed of rice, seafood, vegetables, is low in meat, is not a paleo style diet, is largely devoid of degenerative age related disease and results in a longer life. 2) Stephan, over at the Whole Health Source blog has examined in pretty great details several isolated cultures in Melanesia, Papua New Guinea and Central Africa whose diet is almost exclusively based on starchy tubers with some seafood thrown in. Those cultures are completely devoid of degenerative age related diseases that have plagued the Western civilisation, including CVD you so often seem to appeal to.

I have good reasons to believe that the insulin issue is more complicated than you would like me to think, and is not the only key to good health and longetivity. Restricting the carbohydrate intake appears to be quite important for an average person with no specific pre-existing health conditions, but it does not appear to be the only key to a long life span.

Humans became human thanks to energy- and nutrient-rich animal-source foods, especially highly fatty, nutrient-soaked organ tissues. Pre-agricultural humans and our recent hominid ancestors greatly preferred fatty organ means, like livers, brains, bone marrow, versus muscle meats, which were seen as far less important to eat and probably handed down to the least important people in a tribe.


Proponents of the paleo diet tend to somehow forget that finding food 40000-10000 years ago was nothing like walking into an organic meat market or shopping around at the meat section in the local supermarket. Killing an animal back then was not such a frequent occasion, and the tribe would eat every single part of the animal not because of their advanced nutritional knowledge, but because the prospect of killing another animal was vague, especially in winter. The time in between they would, perhaps, spend foraging for whatever else they could find to eat to survive. Many of our ancestors would starve and die because of the food scarcity; the average life span back then was more close to 18 years rather than to 100+.

Eating meat, in the evolutionary perspective, was critical back then for survival and competition amongst related species, however we have come a long way, have learned a lot and can do better now.

To choose to eat a vegetarian diet now goes against your genetic coding. This is why babies die when only fed a vegetarian diet.


Genetic coding codes us for 20 (22) amino acids, not for their source.

The case of babies who died on a vegetarian diet, I believe you appeal to, was a case of an irresponsible, religiously vegetarian couple who deprived their baby of the mother's milk and fed the baby with apple juice and soy milk. Whether because they were ignorant or uneducated, the fact their baby has died was a terrible thing to happen, however, it is not a common place amongst vegetarians.
There are far more cases when irresponsible non-vegetarian parents have tried to feed their babies with junk food, e.g. hamburgers from McDonald's.

Now that vegetarianism has been around as a fad for 20+ years, there are several recent books from long-time vegetarian practitioners who've come back to eating meat because their health couldn't take it anymore. An example is, The Vegetarian Myth.


The fad, as of recent, has been eating junk food, an excess of fast and nutrionally devoid carbs, "healthy fat free" foods and pigging out on sugary sweets, which equally applies to vegetarians and non-vegatarians.

The fats especially, in plant foods, are inflammatory to humans, and are pro-aging to our cells. Meanwhile, saturated fat, which doesn't oxidize (which is why it doesn't need to by hydrogenated or kept in the fridge) is extremely stable in our body, and also used as a clean-burning fuel source.


You tend to generalise quite a bit. Not everything that grows should be eaten. If you eat a death cap, you will die. If you do not prepare your fugu properly, you will die. It is all about the knowledge and applying the knowledge.

The issue of unhealthy plant fats has been beaten to death around here. No, not every plant oil should be consumed, and plant based saturated fat is easily available in the form of coconut and red palm oils.

There are no humans that can survive on a non-supplemented vegetarian diet for anywhere close to their full lifetime. And those who try, pay a price.


I will venture out on saying that nowadays it is hard to survive on a non-supplemented diet for non-vegetarians as well.

Meat, which the majority of people buy at the local supermarket, almost certainly comes from the grain or soybean fed cattle with the skewed nutrional and fat composition, and, most likely, laced with growth hormones, which is radically different from what our ancestors used to get from the wild meats. You would be getting same inflammatory oils through the grain the cattle has been fed with. Even buying organic meat does not guarantee you will be getting a favourable nutrient compostion, as large supermarket chains now also want to get their share of the organic cake and they buy their organic meats from farmers who feed the cattle with the certified organic grain. Which is still grain, nevertheless. You can only be sure that you are getting all your nutrition if you can trace your grass fed animal back to a trusted local farmer where you can actually see the cow that will end up on your dinner plate. Grass fed meat is significantly more expensive and less convenient to get, so most people will pass it either cluelessly (not knowing the difference in meat of grass and grain fed animals) or because they simply want to eat meat cheap, which is a prevailing occurrence. Raising the grass fed cattle in an industrial world with an ever growing population does not seem to be practical, either; at least at the moment.

Whilst on the topic of supplementation, considering your paleo diet, do you supplement magnesium? If you do not, where do you get it from?

Edited by inkyoto, 24 November 2011 - 03:14 PM.

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#9 inkyoto

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Posted 24 November 2011 - 03:07 PM

The best CRON would be PCRON, or Paleo-CRON. But I do not know of any CRONer eating paleo-style. And thus, they eat sub-optimal diets.


If a diet, which does not agree with the diet of your choice or your current nutritional knowledge, gives you a great health and a long life span, why is it suboptimal?

#10 DukeNukem

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Posted 24 November 2011 - 04:50 PM

The best CRON would be PCRON, or Paleo-CRON. But I do not know of any CRONer eating paleo-style. And thus, they eat sub-optimal diets.


If a diet, which does not agree with the diet of your choice or your current nutritional knowledge, gives you a great health and a long life span, why is it suboptimal?


I'm way past the point of wanting to devote time to convert people, other than give them a little guidance so they can do their own research.

Start here:

Wheat Belly
The Paleo Solution
The New Evolution Diet
Why We Get Fat

And here's the most important thing: Blood tests are always hold the final verdict. Everything else is just talk.

#11 scottknl

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Posted 24 November 2011 - 08:41 PM

The best CRON would be PCRON, or Paleo-CRON. But I do not know of any CRONer eating paleo-style. And thus, they eat sub-optimal diets.


If a diet, which does not agree with the diet of your choice or your current nutritional knowledge, gives you a great health and a long life span, why is it suboptimal?


I'm way past the point of wanting to devote time to convert people, other than give them a little guidance so they can do their own research.

Start here:

Wheat Belly
The Paleo Solution
The New Evolution Diet
Why We Get Fat

And here's the most important thing: Blood tests are always hold the final verdict. Everything else is just talk.

Just a couple of things:
1) Healthy life and long life go hand in hand statistically. It's just plain wrong to suggest that paleo dieters will have healthier but shorter lives than CRONIES.
and
2) My (and most fellow CR practitioners) blood lipid levels are fantastic, and yet you say my diet is sub optimal. With my Total Cholesterol of 138, TG at 46, and HDL at 56 what is my final verdict? Is it any better than yours? With less fats cruising around in my blood stream, I will be less likely to suffer damaged sticky fats from ROS generated by mitochondria than you. Or will your higher level of HDL be more protective from plaque accumulations?
and
3) Many of the links you provided suggest higher milk consumption. This is simply insane if you consider that 3/4 of the worlds population are lactose intolerant. This alone will lead to diarrhea and malnutrition for many of the people who follow this advice.
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#12 DukeNukem

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Posted 25 November 2011 - 12:12 AM

1) Healthy life and long life go hand in hand statistically. It's just plain wrong to suggest that paleo dieters will have healthier but shorter lives than CRONIES.


Never said this. I just said that everyone I happen to know on a CR diet doesn't eat as well as they could, because they still eat a low-fat diet, a diet that includes grains, and avoids saturated fats. So, while a CR diet is the best longevity diet currently known, most people on it appear to be doing it in a suboptimal way, leaving health gains unrealized.

2) My (and most fellow CR practitioners) blood lipid levels are fantastic, and yet you say my diet is sub optimal. With my Total Cholesterol of 138, TG at 46, and HDL at 56 what is my final verdict? Is it any better than yours? With less fats cruising around in my blood stream, I will be less likely to suffer damaged sticky fats from ROS generated by mitochondria than you. Or will your higher level of HDL be more protective from plaque accumulations?


What is the breakdown of your LDL (small particle vs large particle)? What's you A1c? Your HDL is way below mine, which hovers around 100. My total cholesterol is around 230, but that's because my HDL is so high (a good thing), and my LDL is entirely large particle (the good kind). My trigs are 47 as last measured, and my A1c at 4.7.

3) Many of the links you provided suggest higher milk consumption. This is simply insane if you consider that 3/4 of the worlds population are lactose intolerant. This alone will lead to diarrhea and malnutrition for many of the people who follow this advice.


I've said many times that it's okay to drink milk, but only if tested for lactose intolerance.

Edited by DukeNukem, 25 November 2011 - 12:12 AM.

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#13 scottknl

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Posted 25 November 2011 - 05:48 PM

Don't have the A1c measurement, but I have measured my glucose thru out the day recently and it's often in the 80's and 90's range. Last VAP had the particle size in the large size category. So we both have large LDL particle size, same TG. You have more HDL, but I have less fat in my blood stream than you do. So I ask you "Does it make a difference to have less fat circulating in the bloodstream?" If you think it does, then let me know why and provide some sources. I've indicated why I feel it makes a difference due to ROS damage.

#14 DukeNukem

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Posted 28 November 2011 - 12:29 AM

Why do you think I have more fat in my blood stream?

#15 scottknl

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Posted 30 November 2011 - 04:30 AM

Because you quote a much higher total cholesterol number. 230 vs 138 if I remember correctly. Total cholesterol number is a measure of all the fractions of lipids HDL, LDL and VLDL.

Edit to correct my mistake about TG being included in Total Cholesterol. It's not, but VLDL is.

Edited by scottknl, 30 November 2011 - 04:35 AM.


#16 hivemind

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Posted 30 November 2011 - 05:24 AM

What are your blood pressures?

DukeNukem vs. scottknl

Which one of you has lower blood pressure? :)

#17 scottknl

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Posted 30 November 2011 - 05:38 AM

103/67 @ 50 BPM is frequent for me.

#18 platypus

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Posted 30 November 2011 - 11:10 AM

What's your take on using niacin to improve cholesterol profile? I need to decide whether to order Lef Mix with extra niacin or not..

#19 scottknl

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Posted 30 November 2011 - 03:48 PM

My opinion is to supplement to RDA only on niacin and not go over. This means you must track the amount of niacin you get from your diet and compare to RDA and then supplement only the difference to bring you up to RDA. As I suggested in another thread over supplementation with niacin has been shown to reduce LS.

#20 TheKidInside

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Posted 13 December 2011 - 03:07 PM

Having come back from the CR Society conference last month, I have to say that all were healthy, including vegetarians and meat eaters too. I'm starting to think that a carefully planned diet is much more important than the choice of your protein. It's pretty silly to imply that you can't be healthy on a vegetarian diet. [...]

As for thinking you're healthy with 235 cholesterol, heh, well I'm pretty sure you won't last as long as comparably aged CRON folks that have better balanced lipid profiles. That level of serum fat cruising around in your blood is just asking for ROS damage to occur.

Christian Mortensen followed a vegetarian diet and lived to 115+. Don't know if he supplemented.

A CR diet can hide the fact that the diet is not optimal. Most CRer's I know eat a diet that leaves a lot of health gains on the table, by still eating grains, fructose, and plant oils, and not eating enough animal proteins/fats. They are definitely getting health gains, but they're not maximizing their efforts by choosing a poor diet. A vegetarian diet IS a sub-optimal diet.

what the HECK are you basing that on when there's so much research that has been done over the years with the NEGATIVE side effects of animal fats and protein, ESPECIALLY non-organic/ grass fed ones (which are pretty loosely defined)...furthermore, if that was the case why was my nutritionist (who is a staunch anti-vegetarian diet critic) SHOCKED when my blood work came back and he saw how "healthy" my nutrient and metabolic levels are?

that is pure biased opinions my friend. I coach athletes and I NEVER advise them to go on a vegetarian diet unless they want to try themselves and do you know WHY they are curious about it? because a HUGE amount of triathletes and mixed martial arts athletes have embraced it and are performing amazing on it....heck even the greatest triathlete in the history of the Ironman was a straight up VEGAN.

first and foremost there's no ONE SIZE FITS ALL for diets....if there was no one would be gluten sensitive or grain sensitive in general.

Edited by Michael, 30 December 2011 - 02:59 PM.


#21 Ron

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Posted 13 December 2011 - 03:15 PM

first and foremost there's no ONE SIZE FITS ALL for diets....if there was no one would be gluten sensitive or grain sensitive in general.


Totally agree. Folks who go around promoting a high-fat diet for everyone are playing a dangerous game in my opinion. Based on APOE variation alone, 20-25% of the population would be very ill-served to follow such advice.
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#22 TheKidInside

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Posted 13 December 2011 - 03:29 PM

first and foremost there's no ONE SIZE FITS ALL for diets....if there was no one would be gluten sensitive or grain sensitive in general.


Totally agree. Folks who go around promoting a high-fat diet for everyone are playing a dangerous game in my opinion. Based on APOE variation alone, 20-25% of the population would be very ill-served to follow such advice.


one day, God willing, I intend to write a book and my main goal will be to stress what I think is the MOST important part of any dietary regiment...LISTEN TO YOUR BODY! and of course I intend to explain what that means :)

#23 steampoweredgod

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Posted 13 December 2011 - 06:50 PM

That level of serum fat cruising around in your blood is just asking for ROS damage to occur.

The HDL to LDL ratio is more important than total cholesterol,iirc. Saturated fat intake results in larger LDL particles that are more oxidation resistant.
The graph shown in the cholesterol thread indicates optimal number for lowest all cause mortality is around 180 to 240 for normal diets. But I've heard that at 150 or below heart disease becomes non-existent even in large populations(think it was the framingham study), you wouldn't want it extremely lower than 150(not sure what's the lowest that's optimal).

The evolution is an ongoing process, and a 10000 year span is barely enough to assert the results of it.


Evolution in humans should be slower than most animals as we're relatively long lived with low numbers of offspring, that is as we have longer lifetimes and lower population numbers. While many rodents might experience the effect of countless generations in such a span humans would only experience about 500 generations(assuming 20 years per gen, estimate), and that would be weaker still as we'd be dealing with smaller groups the larger the group and the shorter the generation the stronger the power of evolution over a specific period, iirc.


Healthy life and long life go hand in hand statistically. It's just plain wrong to suggest that paleo dieters will have healthier but shorter lives than CRONIES.


We'll have to see how applicable CR benefits are too human. IT is certain that CR mice would outlive mice on any other type of diet, and non-human primates likely would too(maybe protein restricted diets would also be applicable, but that has to be checked), data also suggests that humans will too.

Also we'd have to check how well people are implementing their CRON, obviously suboptimal implementation might carry some risks. I would suggest increasing calories with low glycemic, low protein food sources, until one has a good body composition(if one would like a higher bmi.).

We do know that in normal populations odds of becoming a supercentenarian are 1 in 5 million, and reaching 100 is said to be around 1 in 50... pretty grim I would say... especially when you take into account the disproportionate number of women that make it compared to men, so for men odds are downright abysmal without serious intervention.

Ideally one would want the benefits of 40-60% CR if applicable to humans. That would bring the odds down from winning the lottery like, to pretty certain. Seeing as trying 40-60% CR could be very dangerous, moderate CR with protein restriction or cycling would likely be a better course.

Analysis of Ames mice is also in order, they experience CR like extended lifespan, but their graph on moderate CR seems to indicate that CR radically extends their lifespan even further, seemingly to the same degree, iirc. Combinations of Highest CR with Ames*(not sure if Ames can withstand highest CR, that would need to be checked), would seem to provide over 100% increased maximum lifespan, doubling lifespan in mice.


Researchers discovered that the life expectancy of a 30-year-old vegetarian Adventist woman was 85.7 years, and 83.3 years for a vegetarian Adventist man. This exceeds the life expectancies of other Californians by 6.1 years for women and 9.5 years for men. Non-vegetarian Adventist women in the group had a life expectancy of 84 years, and non-vegetarian men, 81 years.-link


AT least in suboptimal diets, vegetarians(vegans or ovo-lacto vegetarian? would be nice to know) experience a modest lifespan boost of 2.3 years, less than that obtained by exercise and less than the benefit obtained from regular nut consumption.



The Adventist Health Study at Loma Linda University in California revealed those eating nuts daily had up to 60% fewer heart attacks than those who ate nuts less than once per month-link



#24 Brett Black

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Posted 03 January 2012 - 03:45 PM

And, all indications/research shows that a vegetarian diet is less healthy than a paleo-style diet. Quite simply, carbs = sugar, and sugar is a pro-aging "nutrient". It creates more metabolic waste than fatty acids, and creates more glycation issues.

One of the most important and revealing commonalities in people living post-100 is that they have low fasting insulin levels, which generally means they have not had a carb-rich diet -- in fact, none are vegetarians.



There's evidence that vegetarians generally have lower fasting insulin levels than omnivores(s):

Br J Nutr. 2006 Jan;95(1):129-35.

Taiwanese vegetarians have higher insulin sensitivity than omnivores.

Hung CJ, Huang PC, Li YH, Lu SC, Ho LT, Chou HF.

Department of Biochemistry, College of Medicine, Tzu-Chi University, Taiwan.

The present study was designed to examine the effects of habitual consumption of
Taiwanese vegetarian diets on hormonal secretion, and on lipid and glycaemic
control. Of the ninety-eight healthy female adults recruited from Hualien, Taiwan
(aged 31-45 years), forty-nine were Buddhist lactovegetarians and forty-nine were
omnivores. Dietary intakes were measured, and blood levels of nutrients and
hormones were analysed. Vegetarians consumed less energy, fat and protein, but
more fibre than the omnivores. Compared with the omnivores, the vegetarians had,
on average, lower BMI and smaller waist circumference. Except for slightly lower
levels of thyroxine (T4) in vegetarians, vegetarians and omnivores both showed
similar levels of triiodothyronine (T3), free T4, thyroid-stimulating hormone,
T3:T4 ratio and cortisol. Compared with the omnivores, the vegetarians had
significantly lower levels of fasting insulin (median: 35.3 v. 50.6 pmol/l)
and
plasma glucose (mean: 4.7 (se 0.05) v. 4.9 (se 0.05) mmol/l). Insulin resistance,
as calculated by the homeostasis model assessment method, was significantly lower
in the vegetarians than in the omnivores (median: 1.10 v. 1.56), while beta-cell
function was not different between the two groups. BMI and diet were both
independent predictors for insulin resistance, and contributed 18 and 15 % of the
variation in insulin resistance, respectively. In conclusion, Taiwanese
vegetarians had lower glucose and insulin levels and higher insulin sensitivity
than did the omnivores. Diet and lower BMI were partially responsible for the
high insulin sensitivity observed in young Taiwanese vegetarians.

PMID: 16441925

http://www.ncbi.nlm....pubmed/16441925



Eur J Clin Nutr. 2004 Feb;58(2):312-6.

Insulin sensitivity in Chinese ovo-lactovegetarians compared with omnivores.

Kuo CS, Lai NS, Ho LT, Lin CL.

Division of Endocrinology and Metabolism, Department of Medicine, Buddhist Dalin
Tzu Chi General Hospital and School of Medicine, Chia-Yi, Taiwan.

AIM: To compare the insulin sensitivity indices between Chinese vegetarians and
omnivores.
METHODS: The study included 36 healthy volunteers (vegetarian, n=19; omnivore,
n=17) who had normal fasting plasma glucose levels. Each participant completed an
insulin suppression test. We compared steady-state plasma glucose (SSPG), fasting
insulin, the homeostasis model assessment for insulin sensitivity (HOMA-IR and
HOMA %S) and beta-cell function (HOMA %beta) between the groups. We also tested
the correlation of SSPG with years on a vegetarian diet.
RESULTS: The omnivore subjects were younger than the vegetarians (55.7+/-3.7 vs
58.6+/-3.6 year of age, P=0.022). There was no difference between the two groups
in sex, blood pressure, renal function tests and lipid profiles. The omnivores
had higher serum uric acid levels than vegetarians (5.25+/-0.84 vs 4.54+/-0.75
mg/dl, P=0.011). The results of the indices were different between omnivores and
vegetarians (SSPG (mean+/-s.d.) 105.4+/-10.2 vs 80.3+/-11.3 mg/dl, P<0.001;
fasting insulin, 4.06+/-0.77 vs 3.02+/-1.19 microU/ml, P=0.004; HOMA-IR,
6.75+/-1.31 vs 4.78+/-2.07, P=0.002; HOMA %S, 159.2+/-31.7 vs 264.3+/-171.7%,
P=0.018) except insulin secretion index, HOMA %beta (65.6+/-18.0 vs 58.6+/-14.8%,
P=0.208). We found a clear linear relation between years on a vegetarian diet and
SSPG (r=-0.541, P=0.017).
CONCLUSIONS: The vegetarians were more insulin sensitive than the omnivore
counterparts. The degree of insulin sensitivity appeared to be correlated with
years on a vegetarian diet.

PMID: 14749752

http://www.ncbi.nlm....pubmed/14749752



Eur J Nutr. 2006 Feb;45(1):52-4. Epub 2005 Jun 10.

No evidence of insulin resistance in normal weight vegetarians. A case control
study.

Valachovicová M, Krajcovicová-Kudlácková M, Blazícek P, Babinská K.

Slovak Medical University, Institute of Preventive and Clinical Medicine, Limbová
12, 83301, Bratislava, Slovak Republic.

BACKGROUND: Diets rich in carbohydrates with a low glycemic index and with high
fiber content are associated with flat post-prandial rises of blood glucose,
minimal post-prandial insulin secretion and maintenance of insulin sensitivity.
Protective food commodities in the prevention of cardiovascular disease, insulin
resistance syndrome or diabetes are crucial components of the vegetarian diet.
AIM OF THE STUDY: Insulin resistance values were assessed in relation to
different nutrition. Metabolic abnormality is a predictor of age-related diseases
and can be more pronounced in obese subjects. Insulin resistance values in normal
weight subjects of two different nutritional habits were correlated with age.
METHODS: Fasting concentrations of glucose and insulin as well as calculated
values of insulin resistance IR (HOMA) were assessed in two nutritional groups of
apparently healthy adult subjects (age range 19 - 64 years) with normal weight
(body mass index 18.6 - 25.0 kg/m(2)): a vegetarian group (95 long-term
lacto-ovo-vegetarians; duration of vegetarianism 10.2 +/- 0.5 years) and a
non-vegetarian control group (107 subjects of general population on traditional
western diet). Intake of energy and main nutrients (fats, saccharides, proteins)
was similar in both groups.
RESULTS: Glucose and insulin concentrations and IR (HOMA) values were
significantly lower in vegetarians (glucose 4.47 +/- 0.05 vs. 4.71 +/- 0.07
mmol/l; insulin 4.96 +/- 0.23 vs. 7.32 +/- 0.41 mU/l
; IR (HOMA) 0.99 +/- 0.05 vs.
1.59 +/- 0.10). IR (HOMA) dependence on age was only significant in subjects on a
western diet. A significant increase of IR was found already in the age range
31-40 years, compared to vegetarians and it continued in later age decades. Age
independent and low insulin resistance values in vegetarians are a consequence of
an effective diet prevention by long-term frequent consumption of protective
food. Vegetarians had a significantly higher consumption of whole grain products,
pulses, products from oat and barley.
CONCLUSION: The results of age independent and low values of insulin resistance
document a beneficial effect of long-term vegetarian nutrition in prevention of
metabolic syndrome, diabetes and cardiovascular disease.

PMID: 15940383

http://www.ncbi.nlm....pubmed/15940383


Edited by Brett Black, 03 January 2012 - 04:21 PM.


#25 Maecenas

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Posted 03 June 2013 - 03:30 PM

http://www.scientifi..._id=SA_Facebook

Interesting article about misconceptions of paleo dieters




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