5 replies to this topic

[manx]

I just wondered if anyone knows if this topical is an effective way to increase D3 levels in the blood?

[manx]

I'm thinking it might be cheaper than the topical D3 that's sold out of Cripps Pharmacy

[kismet]

CalcTRIol and derivatives have no use - none, whatsoever - in the healthy. That includes all topical drugs. Oral Cholecalciferol is the vitamin D you want.

Edited by kismet, 30 November 2011 - 09:23 PM.

[manx]

CalcTRIol and derivatives have no use - none, whatsoever - in the healthy. That includes all topical drugs. Oral Cholecalciferol is the vitamin D you want.

I'm sure you're right but can you explain why please?

[kismet]

Vitamin D3 (cholecalciferol) can be synthesized by humans in the skin upon exposure to ultraviolet-B (UVB) radiation from sunlight, or it can be obtained from the diet. Plants synthesize ergosterol, which is converted to vitamin D2 (ergocalciferol) by ultraviolet light (2). When exposure to UVB radiation is insufficient for the synthesis of adequate amounts of vitamin D3 in the skin, adequate intake of vitamin D from the diet [or supplements] is essential for health....
In the liver, vitamin D is hydroxylated to form 25-hydroxyvitamin D (calcidiol; 25-hydroxyvitamin D, the major circulating form of vitamin D. Increased exposure to sunlight or increased dietary intake of vitamin D increases serum levels of 25-hydroxyvitamin D, making the serum 25-hydroxyvitamin D concentration a useful indicator of vitamin D nutritional status...
In the kidney, 1,25-dihydroxyvitamin D (calcitriol, 1alpha,25-dihydroxyvitamin D] [is formed]

http://lpi.oregonsta...amins/vitaminD/

Simply put, the body itself normally decides when, where and how much vitamin D (cholecalciferol) to turn into calciTRIol ("active vitamin D"). Therefore, all other routes of administration are unphysiologic and do not represent the human studies that have suggested slight benefits from vitamin D from diet/supplements/UV-radiation.

[manx]

Many, many thanks for the information. I need to process it in my head tonight, work out what this all means, thanks again.