5 replies to this topic

[stephen_b]

Any thoughts on this new type of folate? This is of interest to me since I don't metabolize folic acid well. It's inexpensive too.

http://www.quatrefol...Generation.html
http://www.quatrefol...nismAction.html

[Ampa-omega]

is this better then regular methylfolate?

[MrHappy]

I'll give this a go when I run out of L-methylfolate..

[stephen_b]

is this better then regular methylfolate?

They make that claim:

Developed by Gnosis S.p.A, it represents the fourth generation folate providing greater stability, higher water solubility and multiple ingredient formulation flexibility compared to 5-methyltetrahydrofolate calcium salt guaranteeing an improved bioavailability.

Edited by stephen_b, 11 January 2012 - 03:54 PM.

[pinnacle]

I would look into perhaps only taking the pure 6[S]-5-MTHF.

In this study you can see the 6[R]-isomer may not be so good.

Our results suggest that the 6[R] 5-MTHF isomer is stored in the body until it is released following the administration of a relatively large dosage of folic acid. Folates are stored in tissues, mainly in the liver where folates are bound tight by cytosolic and mitochondrial folate-binding proteins. This binding may not be stereospecific. The biological effects of 6[R] 5-MTHF binding are unclear. Mader et al. (1995) reported that no serious short-term side-effects were seen in patients receiving high doses of 6[R,S] 5-MTHF. Since 6[R] 5-MTHF is not metabolised, it can be speculated that it may inhibit regulatory enzymes related to folate and homocysteine metabolism. Secondly, the bioavailabity of 6[S] 5-MTHF may be reduced due to competition with the 6[R] 5-MTHF diastereoisomer.

http://www.ncbi.nlm....les/PMC1574248/

LEF's Optimized Folate looks promising.

Edited by pinnacle, 31 July 2012 - 01:06 PM.

[August59]

It is almost identically the same as Metfolin. The only difference is the delivery binder. One uses calcium salt and the other use glucosamine salt.