4 replies to this topic

[OneScrewLoose]

I currently have to take a medication that is a strong H1 blocker, which naturally makes me drowsy. But instead of sleeping 5-6 hours a night, I sleep 10-12, and still wake up tired. Is there any way I can take that medication without sleeping for so long. And no, taking a mess of caffeine when I wake up doesn't work.

[PhaQ]

Modafinil is histaminergic. It increases histamine levels in the hypothalamus, that's one of the things that makes it unique and not just another watered down amphetamine like stimulant.

[OneScrewLoose]

Can't have modafinil, D2 agonists do really weird things to me.

Edited by OneScrewLoose, 01 February 2012 - 03:34 AM.

[PhaQ]

I was going to say I was out of ideas, but then I remembered betahistine, and I thought that might be worth a shot. Not sure though, its only a weak h1 agonist, and a very strong H3 antagonist. Look into it and see what you think, I'm no expert.

[PhaQ]

Well I've been reading up on histamine. Since it never seemed to have much recreational potential, I didn't spend years of my youth studying it like other neurotransmitters. Betahistine sounds like it might help a lot. H3 antagonists block the histamine autoreceptors, thereby increasing histamine in the CNS, which promotes wakefulness and vigilance. Give it a shot, the stuff is dirt cheap. I might get some to see if it helps with my own somnolence issues.