26 replies to this topic

[Heh]

Ortho-Core Multivitamin (4/6 pills)
1g Acetyl-L-Carnitine
1g Acetyl-L-Carnitine Arginate
300mg Milk Thistle

10g PIracetam
40mg Noopept
2g Magnesium L-Threonate
2g Lion's Mane Mushroom (20%)

2g Krill Oil
500mg Resveratrol

24 drops Cellfood (trace minerals)
30 drops Celfood Silica

What do you think?

Edited by Joel, 24 February 2012 - 02:13 PM.

[DoomAndGloom]

Are you saying you want to feel like the protagonist in limitless or you currently do feel that way?

Are you already taking these substances? If not, do you have any experience with them individually?

I'm just wondering, since if either of the last two questions are 'no', then I suggest you do try them one at a time. You probably already know that, but I'm just making sure since there was minimal information in the OP.

Edited by DoomAndGloom, 25 February 2012 - 12:00 AM.

[Heh]

I'm going for that feeling.

I'm still waiting on the Noopept, Lion's Mane, and Magnesium L-Threonate, but I started on the others today.

[absent minded]

[whoops]

Edited by absent minded, 26 February 2012 - 04:22 PM.

[evodude]

Mdma also does the trick, even have the limitless after effect of messing you up.

[1thoughtMaze1]

Mdma also does the trick, even have the limitless after effect of messing you up.

Haha, yeah the feeling without the intelligence!

[evodude]

Mdma also does the trick, even have the limitless after effect of messing you up.

Haha, yeah the feeling without the intelligence!

I dont know about u but i feel pretty smart then (^_^)

[1thoughtMaze1]

Mdma also does the trick, even have the limitless after effect of messing you up.

Haha, yeah the feeling without the intelligence!

I dont know about u but i feel pretty smart then (^_^)

Yeah "feel"

[Heh]

I took noopept with some magnesium l-threonate, resveratrol, krill oil, and the ortho-core multi.. Made me sleepy. Maybe my short term memory is a bit better (can remember 5 instead of 3 items), but its been strangely poor recently.

I should order calcium and l-glutamic acid to see if that helps at all, but I got 200mg of Ca from the multi I took.

Damnit.

Piracetam increased my libido (I think), made me feel "happy" and want to go out and socialize, but only above 10 grams. I took 1 gram and 5 grams and got nothing.

I don't feel any alertness or other effects from ALCAR.

The first night I took noopept, I had problems sleeping and falling asleep.

Noticed faster nail growth (probably from one of the CellFoods).

I'm dissapointed that I don't feel anything really.

[dsohei]

Mdma also does the trick, even have the limitless after effect of messing you up.

Haha, yeah the feeling without the intelligence!

I dont know about u but i feel pretty smart then (^_^)

Yeah "feel"

actually, i am much more emotionally and socially intelligent when i'm on mdma. everything is less dangerous, easier to feel safe, easier to get work done because it's a more playful experience. but i don't know if i'd feel like doing calculus on it... of course the next day is "low-energy" day, and it can't be done very often, maybe once a week.

[Sartac]

It's just a movie.

[Cephalon]

Hi Joel!

Maybe it's just the way you take the supplements that does not work for you? Did you try Noopept sublingually?
Piracetam in some individuals (incl me) takes some time to kick in (aka loading).
Don't give up yet ;-) Nootropics work! I use them for about 4 years now and wouldn't want to write a single exam without at least a good dose of Piracetam.
But I have to add, that Piracetam did not work as good until I started using the brand product.
I tried the UCB product but find the Aluid Pharma product to be more effective (odd isn't it? It's just plain pharmaceutical piracetam).

But you won't have the limitless effect with any drug available yet. It's a movie. ... :-)

[SuperjackDid_]

No such pill.

[hippocampus]

what is silica good for?

[Heh]

Silica is good for skin, hair and nails. I'm not sure how much benefit it provides over and above the CellFood.

Update:

Ortho-Core Multivitamin (4/6 pills)
500mg Calcium AEP
24 drops Cellfood (trace minerals)
1 Jarro-Dophilus Probiotic Pill (to help absorption)

2g Krill Oil
500mg Resveratrol

1g Acetyl-L-Carnitine
1g Acetyl-L-Carnitine Arginate
150mg Milk Thistle
130mg 20% Forskolin
10mg PQQ

2.4g PIracetam
1g Aniracetam
200mg Pramiracetam
40mg Noopept
250mg CDP-Choline

2g Magnesium L-Threonate
2g Lion's Mane Mushroom (20%)

Edited by Joel, 03 June 2012 - 04:01 PM.

[manic_racetam]

Honestly it looks like you're making the same assumption that many people make when first starting nootropics (I made the same mistake). And that assumption is, hat taking a few nootropics is good for cognition... well, taking a whole bunch must be better.

The problem comes when you start 5 or 6 substances at once you can't tell which one is affecting you in what way. I remember when I first started nootropics, first I bought aniracetam and choline bitartrate. When that started working I ordered 5 or 6 more nootropics. Within 3 or 4 months my stack was a monster and I was about to have a manic-break. That mania had a lot to do with my mental instability in general but it also had a lot to do with taking a dozen substances without evaluating each one individually first.

I noticed you updated your stack but didn't update the effects you are getting. Just this section of the stack should be making you feel pretty weird already :

2.4g PIracetam
1g Aniracetam
200mg Pramiracetam
40mg Noopept
250mg CDP-Choline

If you're getting mixed results I suggest taking it down to a single racetam with your CDP-Choline. Do each racetam (including Noopept) for a couple weeks each to get a good feel of how they work for you alone. Then start mixing them if you want. This will give you a good idea of which one works best for you in which ways. If you've already done this then obviously disregard this advice.

It's almost inevitable that you'll end up trying just about everything at least once. For me, the reason for that is partly curiosity to try new things and partly because the longest a stack has ever stayed effective for my cognition/ADHD is around 3 months. Then it just slowly decreases in efficacy and poops out eventually. So I'm also constantly adding and changing my stack.

But I'm glad that I've taken the time to do single runs of many of the racetams and other noots. It gives me a good baseline for ideas on mixing different substances when I change things up every couple of months.

Anyway, good luck.

[Heh]

I have been trying this stack, and I haven't noticed any effects (positive, or negative). Well, maybe the Forskolin lowered my pulse. It is kinda dissapointing, actually.

By the way its strange, because Resveratrol now does nothing, but would previously give me more energy (could run farther, wake up easier, etc), increase my libido, and clear up my acne problem.

Edited by Joel, 14 June 2012 - 11:51 PM.

[kevinseven11]

Id drop forskolin and milk thistle
forskolin could counter your cholinergenic* effects and milk thistle definitely decreases libido.

[rmo]

whenever I took a basic stack (every 8 hours) of

piracetam 1.6 grams
aniracetam .8 grams
alpha gpc .8 grams

within 20 min my environment 'colorized' It mas like my whole visual field was enhanced for colors, i could hear and pay attention to more around me, i would get this in control feeling but with tons of potentional to do stuff. It wore off after an hour but i still had increased cognition. It all felt very similar to the way 'limitless' was shot.

[Heh]

Update:

Basics:
2/6 Ortho-Core
1.5g Krill Oil
90mcg MK-7
2000IU Vitamin D-3
30mg OptiZinc
500mg PureWay-C (vitamin C)
2g Magnesium L-Threonate
1g Niacin (once in a while)

Basics+:
150mg Milk Thistle (30:1, 80%)
10mg PQQ
4mg Astaxanthin
2.5mg Elemental Lithium (from Lithium Orotate)
Liddell Vital HGH

CILTEP:
500mg Resveratrol (50%)
130mg Forskolin (20%)
500mg Artichoke Extract
1g Trimethylglycine

NGF:
1g Acetyl-L-Carnitine Arginate
2g Lion's Mane Mushroom (50% poly)
1g Ashitaba
1g Ashwagandha
40mg Noopept (not everyday)

Racetams:
3g Piracetam
1g Centrophenoxine
100mg L-Glutamic Acid

200mg Pramiracetam (not everyday)
750mg Aniracetam (not everyday)

All taken 5 days a week (weekends off).

I don't feel a thing!

I'm not sure if I'm going to keep using PQQ, but for now I'll leave it. What do you think? All the purported effects of Astaxanthin haven't been present for me, even though I started at 8mg before lowering my dosage to 4mg. And throughout this entire time my vision keeps getting blurry, and my eyes keep drifting off center.

Questions:

• Since I take resveratrol, do I actually need Artichoke Extract to experience the benefits of the CILTEP stack?
• Is TMG (and Centrophenoxine) good enough as a dopamine booster in the CILTEP stack, or do I still have to take L-Tyrosine?
• Is 2g Lion's Mane too much, or can I get by with a lower dosage? If I could get by with a lower dosage, then what would that dosage be?
• What about TMG, Ashitaba and Ashwagandha? Is 1g too much of each, or should I cut each to 500mg?
• Is Centrophenoxine good enough to replace CDP-Choline, or do I have to keep taking choline?
• Would L-Theanine be a better source of L-Glutamic Acid for Piracetam non-responders (like myself)?
• Would it be safe to add back in the 500mg of Calcium-AEP I previously took, or is it not worth the risk of kidney stones, etc?

Is there anything that I'm missing from this stack, or that I can take away?

F*ck this voice-2-skull mind control harassment garbage, or whatever it is that this (clearly) worthless person is doing to me. Sometimes I can't even lift a jug of water, or multiply 2 by 3 thanks to this sh*t. And every time I read a stupid comment on one of my posts, I sit there being forced to feel inferior and worthless like I'm not good enough, when I should (and would normally) be ignoring or shutting up the idiot following me around pouring out this never ending stream of stupidity!

Edited by Joel, 04 November 2012 - 04:10 PM.

[Synaptic-Enthusiastic]

Well, this thread has been dead for quite a while but I'll try to revive it.

My closest to the "limitless feeling" -and behaving- is a combination of 10 ml. of Cerebrolysin and...AN ALCOHOL HANGOVER FOLLOWED BY FURTHER DRINKING! Yes, I am aware that alcohol is the opposite of a Nootropic, but It has happened twice in my experience. The following benefits were percieved: Astonishing recall of names, dates, sports results. Also jokes that most people laughed at, sense of confidence, closing domino games 3 plays ahead -I hadn't played in years before this episode-, philosophical thoughts that were picked up by attendants to such party...the list goes on.

You might argue that it was my flawed subjective experience that accounts for such a feeling and that in fact I might have been rolling in dog shit whilst thinking I was in the top of my game. I thought about it too...but feedback from people that interacted with me confirmed this notion, and I still have some evidence -FB chat: coherent, funny, witty conversations-, broken high scores on Rock Band's Drums and Lumosity's Word Bubbles and other games. There has to be something to this.

Now, alcohol itself is a problem for me and has been for years. But this combo has been the closest to the description given in the movie. I'm of course aware that it's a work of fiction we're discussing here, but the description is clear: Motivated, clear headed, confident, fast thinking.

So the question would be...Is there a non-toxic way to emulate alcohol's positive effects with nootropics? The problem seems that alcohol acts on so many different neurotransmitters that it's hard to get to that sweet spot of β-endorphins, GABA enhancement and chatecolamines that produce the unique good feelings that have so many people hooked. - Dr. William Nutt (!) is working on a molecule that produces alcohol's desired effects without the toxic ones, doesn't produce hangover, and has an antidote intended to reverse the effects in order to become fully functional again whenever is needed, a chemical buzzkill of sorts when driving home is needed.

Thoughts?

[3AlarmLampscooter]

Mdma also does the trick, even have the limitless after effect of messing you up.

I'm going to be trying MDAI soon. It is an MDMA-analog developed by David Nichols; it is apparently close in effects to MDMA, but non-neurotoxic and not a controlled substance.

[nuc]

There are days when i have the limitless effect, it doesn't last longer than a few hours, maybe 3-6 in that range. It certainly isn't related directly to what stack you take, but rather the composition of elements in your body at that time. This is obviously quite impossible to measure without having a lot of money, and even then the results might be inaccurate. You sometimes need to consider other things too, such as events that can potentialy ruin your day, perhaps maybe not in the present, but maybe in the future. Your thought process might be interrupted by having to think in the past if things are going so well in the future for having fear that the happiness will eventually end, but it always does, because life is full of suprises. Maybe not everyone calls these suprises and perceives them as problems or something new that they label differently. The point i am making is that everyone deals with matters in different ways, but we somehow are able to relate to certain subjects if it is explained correctly, then again i could be typing something here, and someone might interpret it differently, and this effect can also potentiate a good or bad sensation which can change certain things in his life, whether it's a thought or a moment or the duration of time it will still have an impact.

So instead of rambling on and talking to myself while trying to explain myself in a manner that most might not be able to follow, i will set a small example.

When you are at work, you focus on your job, some jobs require more focus than others and others require more of something else, ect... But ultimately if you are happy with your job, you will do it with ease at times where otherwise you just wouldn't bother if you weren't happy. When you are at work, you know when you are going to start and going to finish (sometimes). You know that you are getting paid, so all these factors combined give you let's say a box telling you that you do > you get and within you do x > you kill x time and within you do x to acheive y > you become z because you have learnt w and within ab has changed > to bc.

All of this is a formula that can be explained in a mathematical method that employs logic based on each individual.

Now you are saying, if i take axv i will get the limitless feeling. Ask yourself if axv has the power great enough to overpower all the equations of your everyday life, which if we began to talk about here would probably be a never ending thread.

The answer is simple, if you know how your body and mind works, sure. If you don't and 99.9% don't, then you are simply waiting for it to happen, and sure if it happens it will simply be something you are expecting to happen, not something you are certain will happen. See the difference? You are either waiting for it to happen because you have absolutely no idea how to make it happen, or you know how to make it happen and expectancy becomes passive and no longer sought.

Edited by nuc, 20 October 2013 - 07:06 PM.

[blacksalt]

As others have indicated on this thread, (facetiously) one substance that might provide the closest "feeling" to the fictional drug featured in the film LIMITLESS might be MDMA, or I might add (although I have not used it myself), a stimulant like cocaine. That being said, although some also deem it a stimulant, while most acknowledge it is an ergodic drug, Modafinil or its cousin Armodafinil (or their less efficient 2nd cousin once removed, Adrafinil) have been said to have been the closest to the fictional drug, NZT-48.

In addition to "feeling", you might also wish to focus on actual performance. Cognitive performance. Some tests available online often cited include Dual N-Back , or sites like http://www.cambridgebrainsciences.com/ and http://cognitivefun.net/

I'm not sure starting out with a mega-stack is the best way to go about matters either. It'd be difficult to ascertain the efficacy of each substance, for one. Negative reactions too. Or, figuring out whether a particular dose is too little or too much. Mixing them all up and hoping for the best doesn't sound like a sound strategy.

[rosen]

Well, this thread has been dead for quite a while but I'll try to revive it.

My closest to the "limitless feeling" -and behaving- is a combination of 10 ml. of Cerebrolysin and...AN ALCOHOL HANGOVER FOLLOWED BY FURTHER DRINKING! Yes, I am aware that alcohol is the opposite of a Nootropic, but It has happened twice in my experience. The following benefits were percieved: Astonishing recall of names, dates, sports results. Also jokes that most people laughed at, sense of confidence, closing domino games 3 plays ahead -I hadn't played in years before this episode-, philosophical thoughts that were picked up by attendants to such party...the list goes on.

You might argue that it was my flawed subjective experience that accounts for such a feeling and that in fact I might have been rolling in dog shit whilst thinking I was in the top of my game. I thought about it too...but feedback from people that interacted with me confirmed this notion, and I still have some evidence -FB chat: coherent, funny, witty conversations-, broken high scores on Rock Band's Drums and Lumosity's Word Bubbles and other games. There has to be something to this.

Now, alcohol itself is a problem for me and has been for years. But this combo has been the closest to the description given in the movie. I'm of course aware that it's a work of fiction we're discussing here, but the description is clear: Motivated, clear headed, confident, fast thinking.

So the question would be...Is there a non-toxic way to emulate alcohol's positive effects with nootropics? The problem seems that alcohol acts on so many different neurotransmitters that it's hard to get to that sweet spot of β-endorphins, GABA enhancement and chatecolamines that produce the unique good feelings that have so many people hooked. - Dr. William Nutt (!) is working on a molecule that produces alcohol's desired effects without the toxic ones, doesn't produce hangover, and has an antidote intended to reverse the effects in order to become fully functional again whenever is needed, a chemical buzzkill of sorts when driving home is needed.

Thoughts?

I cannot relate to your feeling of alcohol intoxication, other than being confident and joking. Never taken Cerebrolysin though.

' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/pubmed/?term=21079922']
Inhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L-carnitine

Abstract
PURPOSE:

Evidence shows that alcohol intake causes oxidative neuronal injury and neurocognitive deficits that are distinct from the classical Wernicke-Korsakoff neuropathy. Our previous findings indicated that alcohol-elicited blood-brain barrier (BBB) damage leads to neuroinflammation and neuronal loss. The dynamic function of the BBB requires a constant supply and utilization of glucose. Here we examined whether interference of glucose uptake and transport at the endothelium by alcohol leads to BBB dysfunction and neuronal degeneration.
MATERIAL AND METHODS:

We tested the hypothesis in cell culture of human brain endothelial cells, neurons and alcohol intake in animal by immunofluorescence, Western blotting and glucose uptake assay methods.
RESULTS:

We found that decrease in glucose uptake correlates the reduction of glucose transporter protein 1 (GLUT1) in cell culture after 50 mM ethanol exposure. Decrease in GLUT1 protein levels was regulated at the translation process. In animal, chronic alcohol intake suppresses the transport of glucose into the frontal and occipital regions of the brain. This finding is validated by a marked decrease in GLUT1 protein expression in brain microvessel (the BBB). In parallel, alcohol intake impairs the BBB tight junction proteins occludin, zonula occludens-1, and claudin-5 in the brain microvessel. Permeability of sodium fluorescein and Evans Blue confirms the leakiness of the BBB. Further, depletion of trans-endothelial electrical resistance of the cell monolayer supports the disruption of BBB integrity. Administration of acetyl-L: -carnitine (a neuroprotective agent) significantly prevents the adverse effects of alcohol on glucose uptake, BBB damage and neuronal degeneration.
CONCLUSION:

These findings suggest that alcohol-elicited inhibition of glucose transport at the blood-brain interface leads to BBB malfunction and neurological complications.

→ source (external link)

Perhaps cerebrolysin+ALCAR+small amounts of alcohol?

As others have indicated on this thread, (facetiously) one substance that might provide the closest "feeling" to the fictional drug featured in the film LIMITLESS might be MDMA, or I might add (although I have not used it myself), a stimulant like cocaine. That being said, although some also deem it a stimulant, while most acknowledge it is an ergodic drug, Modafinil or its cousin Armodafinil (or their less efficient 2nd cousin once removed, Adrafinil) have been said to have been the closest to the fictional drug, NZT-48.

In addition to "feeling", you might also wish to focus on actual performance. Cognitive performance. Some tests available online often cited include Dual N-Back , or sites like http://www.cambridge...ences.com/ and http://cognitivefun.net/

I'm not sure starting out with a mega-stack is the best way to go about matters either. It'd be difficult to ascertain the efficacy of each substance, for one. Negative reactions too. Or, figuring out whether a particular dose is too little or too much. Mixing them all up and hoping for the best doesn't sound like a sound strategy.

Cocaine is too stimulant and edgy/speedy. The pre-onset stage of LSD if similar to the NZT vision including the ability to access 'other' parts of the brain and seemingly foreign ideas. Obviously not a feasible long term solution. My initial racetam experiences were much like NZT, never really combined it with a stimulant stronger than caffeine but I would imagine that it may deliver something similar. I would be cautious experimenting with combinations like that though with regards to risks of excitotoxicity.

[Synaptic-Enthusiastic]

Well...I've had another experience with a similar kind of flow. -The only thing different was the pursuit on action of the enhanced libido-

The substances involved:

Ibogaine - post acute phase. (Converted to Noribogaine. Amazing molecule, not for the faint-hearted)
Cerebrolysin
Low(ish) dose modafinil ( 50 mg)

It was a very unique level of clarity and proactive/productive behavior. -Although some of my basic avoidant behavior was there with regards to social interaction-.

I just got a 9.0 out of 10 score from an assignment from a college subject that usually drains me of energy so much that I have to time-block along the weeks. This one I did in about one hour and a half. -I've dedicated way more time and effort to almost identical tasks with less good results in terms of grades-.

Modafinil = Great enhancer of the inner "logical/verbal machine". Downside? Flattens mood. Makes it difficult for me to flow in social situations because of being "too fast", I have to make artificial pauses to my speech to keep the conversation at a good rhythm. It emulates one characteristic of some autistic people I've work with in the past. Does not provide the calm robot-like focus in the way that Metylphenidate or Selegiline does. Enhances motor function (driving and parking skills are greatly improved).

Cerebrolysin = Unmatched enhancement overall. The only downside is that, even though you're motivated, I've felt so good that I end up doing things that I find interesting/pleasurable. It could help cope better with what "has to be done" if one musters the willpower to do it by force. It does not produce a tendency to productivity; on the contrary, it actually puts me up to follow the amazing ideas that pop in to my head. Well...I've had another experience with a similar kind of flow. -The only thing different was the pursuit on action of the enhanced libido-

The substances involved:

Ibogaine - post acute phase. (Converted to Noribogaine. Amazing molecule, not for the faint-hearted)
Cerebrolysin
Low(ish) dose modafinil ( 50 mg)

It was a very unique level of clarity and proactive/productive behavior. -Although some of my basic avoidant behavior was there with regards to social interaction-.

I just got a 9.0 out of 10 score from an assignment from a college subject that usually drains me of energy so much that I have to time-block along the weeks. This one I did in about one hour and a half. -I've dedicated way more time and effort to almost identical tasks with less good results-.

Modafinil = Great enhancer of the inner "logical/verbal machine". Flattens mood. Makes it difficult for me to flow in social situations because of being "too fast", I have to make artificial pauses to my speech. Does very little for calm robot-like focus in the way that Metylphenidate or Selegiline does. Enhances motor function (driving and parking skills are greatly improved.) I've also found that sustained modafinil consumption seems to decrease the "endorphin high" from exercise, although it might just be a coincidence.

Cerebrolysin = Unmatched enhancement overall. The only downside is that, even though you're motivated, I've felt so good that I end up doing things that I find interesting/pleasurable. It could help cope better with what "has to be done" if one musters the willpower to force oneself. It does not produce a tendency to productivity; on the contrary, it actually puts me up to follow the amazing ideas that pop in to my head.

Ibogaine is a whole category on its own, so discussing it here would be extending an already overextended post.

Thanks for the responses, cheers!

[Synaptic-Enthusiastic]

Well, this thread has been dead for quite a while but I'll try to revive it.

My closest to the "limitless feeling" -and behaving- is a combination of 10 ml. of Cerebrolysin and...AN ALCOHOL HANGOVER FOLLOWED BY FURTHER DRINKING! Yes, I am aware that alcohol is the opposite of a Nootropic, but It has happened twice in my experience. The following benefits were percieved: Astonishing recall of names, dates, sports results. Also jokes that most people laughed at, sense of confidence, closing domino games 3 plays ahead -I hadn't played in years before this episode-, philosophical thoughts that were picked up by attendants to such party...the list goes on.

You might argue that it was my flawed subjective experience that accounts for such a feeling and that in fact I might have been rolling in dog shit whilst thinking I was in the top of my game. I thought about it too...but feedback from people that interacted with me confirmed this notion, and I still have some evidence -FB chat: coherent, funny, witty conversations-, broken high scores on Rock Band's Drums and Lumosity's Word Bubbles and other games. There has to be something to this.

Now, alcohol itself is a problem for me and has been for years. But this combo has been the closest to the description given in the movie. I'm of course aware that it's a work of fiction we're discussing here, but the description is clear: Motivated, clear headed, confident, fast thinking.

So the question would be...Is there a non-toxic way to emulate alcohol's positive effects with nootropics? The problem seems that alcohol acts on so many different neurotransmitters that it's hard to get to that sweet spot of β-endorphins, GABA enhancement and chatecolamines that produce the unique good feelings that have so many people hooked. - Dr. William Nutt (!) is working on a molecule that produces alcohol's desired effects without the toxic ones, doesn't produce hangover, and has an antidote intended to reverse the effects in order to become fully functional again whenever is needed, a chemical buzzkill of sorts when driving home is needed.

Thoughts?

I cannot relate to your feeling of alcohol intoxication, other than being confident and joking. Never taken Cerebrolysin though.

Inhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L-carnitine

Abstract
PURPOSE:

Evidence shows that alcohol intake causes oxidative neuronal injury and neurocognitive deficits that are distinct from the classical Wernicke-Korsakoff neuropathy. Our previous findings indicated that alcohol-elicited blood-brain barrier (BBB) damage leads to neuroinflammation and neuronal loss. The dynamic function of the BBB requires a constant supply and utilization of glucose. Here we examined whether interference of glucose uptake and transport at the endothelium by alcohol leads to BBB dysfunction and neuronal degeneration.
MATERIAL AND METHODS:

We tested the hypothesis in cell culture of human brain endothelial cells, neurons and alcohol intake in animal by immunofluorescence, Western blotting and glucose uptake assay methods.
RESULTS:

We found that decrease in glucose uptake correlates the reduction of glucose transporter protein 1 (GLUT1) in cell culture after 50 mM ethanol exposure. Decrease in GLUT1 protein levels was regulated at the translation process. In animal, chronic alcohol intake suppresses the transport of glucose into the frontal and occipital regions of the brain. This finding is validated by a marked decrease in GLUT1 protein expression in brain microvessel (the BBB). In parallel, alcohol intake impairs the BBB tight junction proteins occludin, zonula occludens-1, and claudin-5 in the brain microvessel. Permeability of sodium fluorescein and Evans Blue confirms the leakiness of the BBB. Further, depletion of trans-endothelial electrical resistance of the cell monolayer supports the disruption of BBB integrity. Administration of acetyl-L: -carnitine (a neuroprotective agent) significantly prevents the adverse effects of alcohol on glucose uptake, BBB damage and neuronal degeneration.
CONCLUSION:

These findings suggest that alcohol-elicited inhibition of glucose transport at the blood-brain interface leads to BBB malfunction and neurological complications.

→ source (external link)

Perhaps cerebrolysin+ALCAR+small amounts of alcohol?

As others have indicated on this thread, (facetiously) one substance that might provide the closest "feeling" to the fictional drug featured in the film LIMITLESS might be MDMA, or I might add (although I have not used it myself), a stimulant like cocaine. That being said, although some also deem it a stimulant, while most acknowledge it is an ergodic drug, Modafinil or its cousin Armodafinil (or their less efficient 2nd cousin once removed, Adrafinil) have been said to have been the closest to the fictional drug, NZT-48.

In addition to "feeling", you might also wish to focus on actual performance. Cognitive performance. Some tests available online often cited include Dual N-Back , or sites like http://www.cambridge...ences.com/ and http://cognitivefun.net/

I'm not sure starting out with a mega-stack is the best way to go about matters either. It'd be difficult to ascertain the efficacy of each substance, for one. Negative reactions too. Or, figuring out whether a particular dose is too little or too much. Mixing them all up and hoping for the best doesn't sound like a sound strategy.

Cocaine is too stimulant and edgy/speedy. The pre-onset stage of LSD if similar to the NZT vision including the ability to access 'other' parts of the brain and seemingly foreign ideas. Obviously not a feasible long term solution. My initial racetam experiences were much like NZT, never really combined it with a stimulant stronger than caffeine but I would imagine that it may deliver something similar. I would be cautious experimenting with combinations like that though with regards to risks of excitotoxicity.

I've only had one experience with LSD which was far from good in terms of purposeful experimentation. -Although I got good insight about self-control out of it-

For a sustainable benefit from LSD-like substances you might want to investigate and try hydergine. It has many benefits to it. I couldn't sustain my dosing protocol because it exacerbated my low blood pressure symptoms.

Cheers!