7 replies to this topic

[MrSpud]

Either stimulating them as in increasing their activity and/or stimulating mitosis of glial cells?

[Ampa-omega]

well. GDNF is a start, things that increase that are deprenyl and royal jelly.
pubmed search here http://www.ncbi.nlm....ase gliogenesis

Edited by Ampa-omega, 26 April 2012 - 03:56 AM.

[gray.bot]

I'm researching how to increase glial cells and mylenation.

I'm already taking deprenyl - have heard of royal jelly before but thought it was just a bit of bvitamins and minerals.

Does anyone else know which nootropics increase glial cells?

[abelard lindsay]

Wow... someone in pubmed is trolling your desire for gliogenesis...
http://www.ncbi.nlm....pubmed/19251376

Med Hypotheses. 2009 Jun;72(6):753. doi: 10.1016/j.mehy.2009.01.023. Epub 2009 Feb 28.
Einstein's brain: gliogenesis in autism?
Yuan TF.
Abstract

The hypothesis is that the increased glia/neuron ratio in cortical areas of Einstein's brain is the sign of autism disorder rather than the evidence that more glial cells make a genius.

That's the entire abstract. It's from the journal of medical hypotheses after all.

Edited by abelard lindsay, 20 March 2013 - 05:14 AM.

[abelard lindsay]

Taking this topic a little more seriously

http://www.ncbi.nlm....pubmed/23281078

Glutamate dehydrogenase 1 and SIRT4 regulate glial development.

GDH1 is allosterically regulated by many factors, and has been shown to be inhibited by the ADP-ribosyltransferase sirtuin 4 (SIRT4), a mitochondrially localized sirtuin. Here we show that SIRT4 is localized to mitochondria within the brain. SIRT4 is highly expressed in glial cells, specifically astrocytes, in the postnatal brain and in radial glia during embryogenesis. Furthermore, SIRT4 protein decreases in expression during development. We show that factors known to allosterically regulate GDH1 alter gliogenesis in CTX8 cells, a novel radial glial cell line. We find that SIRT4 and GDH1 overexpression play antagonistic roles in regulating gliogenesis and that a mutant variant of GDH1 found in HI/HA patients accelerates the development of glia from cultured radial glia cells.
...

http://en.wikipedia....dehydrogenase_1

Glutamate dehydrogenase (GDH) catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate using NAD or NADP as cofactors.

So NADP and NAD which are metabolically derived from NADH (http://en.wikipedia.org/wiki/NADH)....

Anyway, I'm tired, more on this tommorow.

[LucidMind]

Hericium erinaceus (a mushroom) AKA Lion's Mane.

http://www.huffingto..._b_1725583.html

[LearningFromThePast]

well. GDNF is a start, things that increase that are deprenyl and royal jelly.
pubmed search here http://www.ncbi.nlm....ase gliogenesis

Don't forget (-)-BPAP; It is (-)-Deprenyl's (Selegine's) successor and supposedly is much more powerful.

[Olon]

Cognitive effects by inhibitors of astrocyte activation have been shown.
http://www.ncbi.nlm....=p2y1 cognitive
Currently they are my favourites for autism treatment.
P2Y1 receptor activation might be beneficial for psychiatric diseases, but I am less sure about that. Would be a bit problematic because of thrombosis risk, however, but maybe positive allosteric modulators plus aspirin would do the job.