Seems that this D-vitamin overdosing has been way overpropotioned. Surely we can understand that dosing can be rather difficult if one is living in a sunny country. But it seems that toxic outcomes from vitamin D supplementation is rather rare and it is also a vitamin that is difficult to overdose.
Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity.Effects of Large Doses of Calciferol, 100.000IU per day for a year.Keep in mind that sun exposure can give as equally high dosages of vitamin D, but the body has a built in mechanism to prevent overdosing. This doesn´t apply for supplementation so the mechanism get´s bypassed. Overdosing seems to come from prolonged use, so I can easilly swallow the whole bottle without any dangerous outcomes.
The overdosing issue with 10.000IU seems to be fake. LOWEST OBSERVED ADVERSE EFFECT LEVEL
Equally important with respect to daily vitamin D intakes is the lowest observed adverse effect level (LOAEL). Again, there is a lack of evidence to support statements about the toxicity of moderate doses of vitamin D. For instance, in the 1989 US RDA it is stated that 5 times the DRI for vitamin D may be harmful (5). This recommendation relates back to a 1963 expert committee report (6), which then refers back to the primary reference, a 1938 report in which linear bone growth was suppressed in infants given 45–158 μg (1800–6300 IU) vitamin D/d (11). The study was not conducted in adults and, thus, does not form a scientific basis for a safe upper limit in adults. The same applies to a statement in the 1987 council report from the American Medical Association: “dosages of 10 000 IU/d for several months have resulted in marked disturbances in calcium metabolism, and, in some cases—death.” Two references were cited to substantiate this claim. One reference was to a review article about vitamins in general, which gave no evidence for and cited no other reference for its claim of toxicity at vitamin D doses as low as 250 μg/d (10 000 IU/d) (12). The other reference dealt with 10 patients with vitamin D toxicity reported in 1948, for whom the vitamin D dose was actually 3750–15 000 μg/d (150 000–600 000 IU/d) (13); of note, all of the patients recovered. These same points were rehashed in the 1990 Institute of Medicine Publication, Nutrition During Pregnancy (14). The issue of poorly substantiated claims of toxicity extends even to the most recent revision for vitamin D intakes published by the National Academy of Sciences (15).
Here´s some referencedata with 10.000IE used.Next question is how far up can you go before being on dangerous levels?
Edited by Brainfogged, 20 May 2012 - 01:43 PM.
