This is more of an overall review paper and mostly winds up referring to the PDE inhibition mechanism paper already published in Cell, ( 2012 Feb 3;148(3):421-33) but it still a pretty good 2 page overview
of the last 5-6 years if anyone wants that.
Angew Chem Int Ed Engl. 2012 Jun 21. doi: 10.1002/anie.201203059. [Epub ahead of print]
Resveratrol Still Has Something To Say about Aging!
Quideau S, Deffieux D, Pouységu L.
Source Univ. Bordeaux, Institut des Sciences Moléculaires (CNRS-UMR 5255) & Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac Cedex (France). s.quideau@iecb.u-bordeaux.fr.
Abstract
A votre Santé! The mechanism by which resveratrol, a hydroxystilbenoid polyphenol found in grapes and present in wine, exerts antiaging metabolic benefits has been uncovered. Chung and co-workers have found that it works by inhibiting cAMP phosphodiesterases, thus triggering a signaling cascade that leads to the possible activation of the mammalian enzyme sirtuin 1.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. PMID: 22730253
