2 replies to this topic

[mycotheologist]

For those of us who are reluctant to take a psychedelic dose of ibogaine (i.e. to avoid the hassle of having to get an experienced sitter, finding a safe and comfortable setting and all the other necessary preparations), is ibogaine of any use in curing post acute withdrawal symptoms?

[medievil]

Yes it can be used in low daily treshold doses and works for withdrawals, cravings and tolerance that way. There are anecdotes of using it this way on bluelight and other fora.

[mycotheologist]

Thanks. I'm going to try voacanga africana seeds, rather than iboga bark. V. Africana seeds and bark contain a very low concentration of ibogaine but contains another alkaloid called voacangine:
https://en.wikipedia...wiki/Voacangine
which according to wikipedia

It has also been demonstrated in animals to have similar anti-addictive properties to ibogaine itself.

EDIT: I looked up the article cited by the wiki page and heres the abstract:

Objective:To investigate the constituents of indole alkaloids in Ervatamia yunnanensis and their antiaddictive bioactivities. Methods: The preliminary alkaloids(TEYA) were extracted by 95% EtOH from the stems of Ervatamia yunnanensis.TEYA was then purified by silica gel and Sephadex LH20 column chromatography repeatedly and its structure was identified with spectral analysis.The antiaddictive effects of these indole alkaloids were evaluated by Conditioned Place Preference(CPP) experiments.Results: Nine indole alkaloids were obtained and identified as: coronaridine(1),voacangine(2),3-R-ethoxycoronaridine(3),3-S-ethoxycoronaridine(4), 19-epi-heyneanine(5),heyneanine(6),19-epi-voacristine(7),coronaridine hydroxyindolenine(8) and 12-methoxyl-voaphylline(9).Among them voacangine (2) and 19-epi-voacristine(7) were effective in prevention and treatment of addiction induced by morphine in rats(n=8).Conclusion: Compounds 3,4,8,and 9 have been isolated from Ervatamia yunnanensis for the first time and coronaridine-type indole alkaloids are the main antiaddictive constituents of E.yunnanensis.

Source: http://www.shvoong.c.../#ixzz20zjgxWY3

First time I hear of Ervatamia yunnanensis.

Edited by mycotheologist, 18 July 2012 - 05:06 PM.