EDIT: I had it wrong, this compound is non PSYCHEDELIC, not non psychoactive. According to the wiki article, it has affinity for mu and kappa opioid receptors so it most likely does have significant psychoactivity. However, if its non psychedelic, then its kappa opioid affinity can't be too great, leaving only mu opioid activity. Imagine that, a drug with the effects of heroin but is ANTIaddictive.
Ever since learning about ibogaines anti-addictive properties, I planned on steering towards research in that area once I get my chemistry degree in hopes that I may someday discover an ibogaine analogue that has the anti-addictive properties, without the psychoactive properties (because if its not psychoactive, they have no excuse to prohibit it). Little did I know, a compound like this has already been discovered:
https://en.wikipedia...oxycoronaridine
I found out about it from reading this abstract on pubmed:
A review of chemical agents in the pharmacotherapy of addiction.
Levi MS, Borne RF.
Source
Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Abstract
Chemical substance abuse has tormented mankind throughout history. A number of chemical approaches have been employed in an attempt to treat chemical addiction. Unfortunately, most of these have proven unsuccessful though several chemical entities have been shown to be moderately effective. The naturally occurring alkaloid ibogaine has been reported to interrupt the cravings for alcohol, cocaine and opiates. Other alkaloids from Tabernanthe iboga, such as ibogamine and tabernanthine, provide insight into the structure activity relationship at the different receptors believed to be involved in addiction. The synthetic iboga alkaloid congener, 18-MC, also shows potential as an anti-addictive agent without the hallucinogenic effects of ibogaine. Additionally, acamprosate, BP 897, GBR12909, lofexidine and memantine have shown promising results in the treatment of addiction. All of these leads provide a start for the medicinal chemist to design anti-addictive agents, since currently no drugs are approved in the U.S. for the treatment of addictions to cocaine, methamphetamine, other stimulants or PCP.
Anyone here done much research into this compound?
Edited by mycotheologist, 18 July 2012 - 06:58 PM.
