4 replies to this topic

[the_newsoul]

I really hope someone can help me to clarify this.

Apparently, Lion's Mane (Hericium erinacius) promotes NGF. There is the mycelia and the fruiting body.

So:

-If I am not mistaken, the fruiting body contains herecinones and the mycelia contains erinacines.

You can read more here: https://www.explorep...erinaceus-.html

-In this study, it is stated that herecinones are not the responsible of NGF: "In conclusion, H. erinaceus contains active compounds that stimulate NGF synthesis via activation of the JNK pathway; these compounds are not hericenones."

Source: http://www.ncbi.nlm....pubmed/18758067

-In the other hand, this study claims something different: "Especially hericenones and erinacines isolated from its fruiting body stimulate nerve growth factor (NGF) synthesis, which expects H. erinaceus to have some effects on brain functions and autonomic nervous system.

Source: http://www.ncbi.nlm....pubmed/20834180



I will really appreciate any comments, and it would also be interesting to know if anyone who's having a good response to this mushroom is taking the fruiting body or the mycelia.

Thanks!!

[kevinseven11]

I take the full spectrum of the mushroom but I guess mycelia are most potent.
The contradicting study was just assuming I think. I would trust the people who sought out to see which part actually stimulates NGF.

Edited by kevinseven11, 15 August 2012 - 06:26 PM.

[1thoughtMaze1]

i hope its not useless i just bought two bottles!

[jayfoxpox]

For the second paper that says that both cause NGF is assuming both are and maybe they cited a study that shows it.

If you look at the other paper I think it tests the herocenone seperately from the total plant

" However, hericenones C, D and E, constituents of H. erinaceus, failed to promote NGF gene expression in 1321N1 cells."

This implies they had 3 differeny samples of hericenones and tested them.

"Furthermore we examined the efficacy of H. erinaceus in vivo. ddY mice given feed containing 5% H. erinaceus dry powder for 7 d showed an increase in the level of NGF mRNA expression in the hippocampus."

Although evidence fails to support the claim that herecinones plays a role in NGF. I think it's hasty to suggest it doesn't play a role. If they compare three substances :fullspectrum extract ,hericenones and erinacines; and compare the amount of NGF to judge whether or not hericenone , ernacine has a role , works synergisticly , or a completely different compound is responsible.

[kevinseven11]

Why is lions mane such a weak supplement when it helps with NGF!? This is the big question that hopefully will be answered!