Edited by Clarity, 10 October 2012 - 05:09 PM.
Adrenal Insufficiency, has anyone recovered?
#31
Posted 10 October 2012 - 05:04 PM
#32
Posted 10 October 2012 - 05:12 PM
#33
Posted 10 October 2012 - 05:29 PM
It's interesting that you mention you have very high folate levels. Me too - off the charts. Dr's say it's fine, but I had found an article saying it was pro-oxidizing when your levels are above the top range. I don't absorb B12 well by oral form, but when taking sublingual (same with folate), it also goes over the top range very quickly.
#34
Posted 10 October 2012 - 05:37 PM
A prospective study in the United States, conducted after fortification, has reported that a high intake of folate, estimated from questionnaires completed by >2000 persons in Chicago, is associated with a risk of cognitive decline in the elderly, especially in those who took vitamin supplements containing >400 μg folic acid/d (60). The rate of cognitive decline in the high-folate-intake group was slower in those who also took supplements containing extra vitamin B-12 than in those consuming the Recommended Dietary Allowance (RDA) for vitamin B-12. This is consistent with the cross-sectional findings of Morris et al (52) that high folate is a risk in persons with a low vitamin B-12 status. On the other hand, other prospective studies on folate intake in the United States (61) and on serum folate concentrations in Italy (62) in the elderly found that low folate intake or status is a risk factor for dementia. In the latter 2 studies, it would be valuable to know the vitamin B-12 status of the populations. In addition, it is also possible that the harmful effect of high folate intake in the Chicago study is related to a combination of folic acid fortification and a high intake of folic acid–containing supplements (51). A recent clinical trial showed that those who took folic acid (0.8 mg/d) for 3 y showed improved performance on certain cognitive tests compared with those who took placebo (63). It is notable that subjects were excluded from this trial if they had poor vitamin B-12 status.
After folate fortification in the United States, the proportion of elderly in the cohort studied by Morris et al (52) with a high folate, low vitamin B-12 status is ≈4%. If the same proportion of all elderly in the United States is affected, then ≈1.8 million elderly might be at increased risk of cognitive impairment and anemia because of an imbalance between folate and vitamin B-12. In Canada, the proportion of elderly women that had high serum folate (>45 nmol/L) and vitamin B-12 insufficiency (<165 pmol/L) is 0.61% (64). If similar proportions occur in the United Kingdom after folic acid fortification, then 25 000–170 000 elderly would have this particular combination, and so may be potentially at high risk of anemia and cognitive impairment (52).
http://ajcn.nutritio...t/87/3/517.full
Apparently it's been shown high folate is ok if you have high B12 levels. Otherwise it increased cognitive decline.
Edited by Clarity, 10 October 2012 - 05:37 PM.
#35
Posted 13 October 2012 - 06:39 AM
http://www.longecity...inese-medicine/
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