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identifying the real age


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#1 seivtcho

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Posted 25 August 2012 - 05:40 PM

Is there some medical/biochemical/physiological or whatever criterion, that can be used for identifying the real age in a human? I mean, is there another way to be scientifically determined the age of a man, rather than documentation.

#2 scottknl

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Posted 25 August 2012 - 06:50 PM

I think you have to saw thru a bone and then count the rings :) No, wait a minute, that's for trees.

AFAIK there's no way to tell. If there was, then ageing studies would cost much less.

#3 mikeb80

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Posted 26 August 2012 - 12:05 PM

It's possible (yet not 100% accurate) an estimation of individual age based on telomere shortening.

Another way is a test that quantifies the amount of sjTRECs (products of immune cells known as T cells) in the total DNA extracted from a small blood sample and uses a reference gene not affected by age to compensate for the total amount of DNA in the sample.

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#4 Avatar of Horus

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Posted 19 May 2015 - 01:08 AM

There seems to exist an epigenetic "biological clock":

My recent post has some relevant infos, in the topic:
Creating a unified theory of aging - Aging Theories - LONGECITY
also more details about the biological scientific background in a broader context are available there.

There were some news about a recent finding, named as human "biological clock":

UCLA scientist uncovers biological clock able to measure age of most human tissues
Elaine Schmidt ,    October 21, 2013
Everyone grows older, but scientists don't really understand why. Now a UCLA study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process.
Published in the Oct. 21 edition of the journal Genome Biology, the findings could offer valuable insights to benefit cancer and stem cell research.
While earlier biological clocks have been linked to saliva, hormones and telomeres, the new research is the first to result in the development of an age-predictive tool that uses a previously unknown time-keeping mechanism in the body to accurately gauge the age of diverse human organs, tissues and cell types. ...


Biomarkers and ageing: The clock-watcher
Biomathematician Steve Horvath has discovered a strikingly accurate way to measure human ageing through epigenetic signatures.
W. Wayt Gibbs    08 April 2014
... the clock's median error was 3.6 years ... for a broad selection of tissues. That accuracy improves to 2.7 years for saliva alone, 1.9 years for certain types of white blood cell and 1.5 years for the brain cortex. The clock shows stem cells removed from embryos to be extremely young and the brains of centenarians to be about 100.
“Such tight correlations suggest there is something seemingly immutable going on in cells,” says Elizabeth Blackburn of the University of California, San Francisco, who won a Nobel prize for her research on telomeres - caps on the ends of chromosomes that shorten with age. It could be a clue to undiscovered biology, she suggests. ...
Horvath ... “Everyone who develops biomarkers knows what to expect: a very strong biomarker gives you a correlation of, say, 0.6 or 0.7.” For example, the correlation between age and the length of telomeres is less than 0.5. For Horvath's clock algorithm, that figure is 0.96. ...

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