6 replies to this topic

[ClarkSims]

Here is a study that reports that suspended c60 in corn oil caused dna damage.


http://www.ncbi.nlm....les/PMC2685830/


http://www.ncbi.nlm....les/PMC2421009/

I find it interesting that they used sonification to suspend the nanoparticles in both studies.
Maybe they are seeing toxicity from compounds that created by sonification?

It is curious that they see c60 causing oxidative stress, rather than acting as an antioxidant.

Does anyone else have any thoughts?

[ClarkSims]

This is a great articles that has two tables which summarize the experiments which demonstrate toxic reactions, and antioxidant reactions


http://www.owndoc.co...ne-toxicity.pdf

[Turnbuckle]

Here is a study that reports that suspended c60 in corn oil caused dna damage.


http://www.ncbi.nlm....les/PMC2685830/


http://www.ncbi.nlm....les/PMC2421009/

I find it interesting that they used sonification to suspend the nanoparticles in both studies.
Maybe they are seeing toxicity from compounds that created by sonification?

It is curious that they see c60 causing oxidative stress, rather than acting as an antioxidant.

Does anyone else have any thoughts?

You perhaps missed this--

Suspension of particles in saline solution or corn oil yielded a similar extent of genotoxicity, whereas corn oil per se generated more genotoxicity than the particles.

[ClarkSims]

Here is a study that reports that suspended c60 in corn oil caused dna damage.


http://www.ncbi.nlm....les/PMC2685830/


http://www.ncbi.nlm....les/PMC2421009/

I find it interesting that they used sonification to suspend the nanoparticles in both studies.
Maybe they are seeing toxicity from compounds that created by sonification?

It is curious that they see c60 causing oxidative stress, rather than acting as an antioxidant.

Does anyone else have any thoughts?

You perhaps missed this--

Suspension of particles in saline solution or corn oil yielded a similar extent of genotoxicity, whereas corn oil per se generated more genotoxicity than the particles.

I did miss that!
Thank you for pointing it out.

[xtronics]

whereas corn oil per se generated more genotoxicity than the particles.

Rather interesting - corn oil is loaded with 18:2 ω-6 linoleic acid (which is related to ox damage) (C18:2 59.6%) . It appears that the corn oil paper suggest that C60 may be protective.

Avoiding 18:2 ω-6 linoleic acid appears to be a good idea.

[taho]

It is a good idea. 18:1 ω-9 oleic acid is much less prone to lipid oxidation.

[xtronics]

There is a lot about different FA that we still don't understand - I suspect that the increase in 18:2 ω-6 linoleic acid consumption from the 1960's is a suspect of what is causing the T2D pandemic.

We need to know a lot more about the effects of different FA. I have lots of notes I've collected here . What we know about FA is confounded with the increase in BG - most fats are harmless if BG is well regulated ( stays below 110 postprandial ) - but if there is elevated BG - it becomes toxic - increases oxLDL - auto-immune reactions that cause lots of disease.

Petro has done a wonderful job of picking papers apart that have to do with fats over on hyperlipid. One has to be extremely careful about what papers mean as there is a torrent of junk/fraud papers people pump out to keep the grant-gravy-train flowing their way. The usual grant-vulture produces a paper that agrees with the accepted theory - no matter what the data says or how far they have to twist and hide data. (There are papers that claim to prove the danger of eating fats based on a test diet that is actually full of old Crisco (trans-fats ) as if the diet was a proxy for eating meat. What is actually in the diet is carefully hidden from the causal reader ) .

This has a lot to do with C60 - the membranes it likely protects are made of phospholipids - the fat we eat moves around as triglycerides and is broken down into FFA(Free Fatty Acids) for transport through the cell walls.

Edited by xtronics, 07 November 2012 - 10:13 PM.