17 replies to this topic

[MrHappy]

http://news.yale.edu/2012/10/04/yale-scientists-explain-how-ketamine-vanquishes-depression-within-hours

Yale scientists explain how ketamine vanquishes depression within hours

Many chronically depressed and treatment-resistant patients experience immediate relief from symptoms after taking small amounts of the drug ketamine. For a decade, scientists have been trying to explain the observation first made at Yale University.
Today, current evidence suggests that the pediatric anesthetic helps regenerate synaptic connections between brain cells damaged by stress and depression, according to a review of scientific research written by Yale School of Medicine researchers and published in the Oct. 5 issue of the journal Science.
....

In their research, Duman and others show that in a series of steps ketamine triggers release of neurotransmitter glutamate, which in turn stimulates growth of synapses. Research at Yale has shown that damage of these synaptic connections caused by chronic stress is rapidly reversed by a single dose of ketamine.
....

[MrHappy]

Whoops, looks like this is already being discussed:
http://www.longecity...synaptogenesis/

[SuperjackDid_]

Thank for your post ,let me try ketamine for my depression from Piracetam usage .

[SuperjackDid_]

I found it illegal here ,but not sure can it import it for personal use to Thailand?

[MrHappy]

I found it illegal here ,but not sure can it import it for personal use to Thailand?

It's scheduled / illegal in most places, because it gets abused as a 'party drug'.
You could try for a prescription, depending on the laws / status in Thailand.

[hippocampus]

Lol, I don't think Nootropix knows what dissociative hallucinogenic anestetic is

[FDA Approved]

In most of those studies they seem to administer the ketamine through IV, if this wasn't the case I would buy a gram to test it out.

[Turnbuckle]

I found it illegal here ,but not sure can it import it for personal use to Thailand?

It's scheduled / illegal in most places, because it gets abused as a 'party drug'.
You could try for a prescription, depending on the laws / status in Thailand.

How can it be a party drug? Is it like the party drugs alcohol and tobacco? No, just the opposite, it's not a social drug at all. So sounds like the government has done a good job with its propaganda.

[Sholrak]

Thank for your post ,let me try ketamine for my depression from Piracetam usage .

What do you mean?

How could Pira cause depression to you?

[SuperjackDid_]

Thank for your post ,let me try ketamine for my depression from Piracetam usage .

What do you mean?

How could Pira cause depression to you?

I think i should not discuss about Piracetam in every thread i post , tingling symptom at my foot is major case of depression for me ,very annoying .

I think too much information lie around on this forum and very confusing ,choline not help at all ,even it further enhanced depression ,so i try avoid it as possible ,
but sometime i take 1 lecithin pill hope it help for liver and brain ,etc ,but depression and headache hit me so hard sometime.

I never using illegal drug so i not know about Ketamine but if it can help me cure my depression ,should worth a try .

Feel free PM me about root cause of Piracetam induce in depression ,um maybe call long-term depression ,because of i have stop it more than a month depression not life up .

Problem is when newbie try to start Piracetam ,most everyone recommend it ,but result in depression, tingling ,unable to concentrate ,negative effect ,etc ,no one can help any ?that very very bad.

Feel free to move or delete my post ,i know i have posted and mention in many places ,with no good respond ,magnesium and tuarine just temporary fix.

I not want this great community have ton of very annoying post about negative Piracetam ,but why not just tell the truth about it .

I might have too dumper to filter out of Piracetam garbage post and focus on the right track .

Piracetam is great thing for nootropic seller ,i tried many-thing to deal with depression but none effective, i just know the truth or mechanism why Piracetam give me permanet tingling ,i have massive walking problem ,very hurt .

I will go,give me root cause solution .

[hippocampus]

Nootropix, I recommend you English lessons or using Rosetta Stone or something like that. It may not help your depression, though

[8bitmore]

Nootropix, I recommend you English lessons or using Rosetta Stone or something like that. It may not help your depression, though

no, it might not help him with the depression but it would make it very much easier for the rest of to asses whether he is talking about the discomfort experienced by having "tinkling in the foot" and "massive walking problem" or a psychological mood disorder.

Anyway, on the semi-serious side: I always think that people who ramble on and on about some exotic substance (in this case Piracetam) causing god knows how many issues for them should seriously save up their money for a visit at a proper health clinic instead of buying more nootropics (if they haven't got access to public healthcare that is, in which case: go get it checked, now!) - there might well be underlying problem that the nootropics are at best masking and at worst exasperating!

Edit: sorry for spamming this thread further; the topic here is ketamine triggering synaptic bio-genesis that works its magic within hours; which is frankly amazing!

Edited by 8bitmore, 14 November 2012 - 07:03 PM.

[MrHappy]

For people sensitive to cholinergics, piracetam + choline (or lecithin) could cause depressive symptoms.

A few people that experienced increased depressive symptoms from uridine + choline + dha + vitamins, etc. had great success for depression when removing choline from the stack.

[medievil]

Methoxetamine seems to have simular benefits and is freely available online and legal in most country's.
Got some myself atm

[Turnbuckle]

The improvement in symptoms, which are evident just hours after ketamine is administered, lasts only a week to 10 days.

So you have to take it once a week. Is that a big deal?

In their research, Duman and others show that in a series of steps ketamine triggers release of neurotransmitter glutamate, which in turn stimulates growth of synapses.

So why not just take glutamine and riboflavin 5'-phosphate--an excellent activator of glutaminase in the brain? Glutaminase generates glutamate from glutamine, and there you are.

[MrHappy]

The improvement in symptoms, which are evident just hours after ketamine is administered, lasts only a week to 10 days.

So you have to take it once a week. Is that a big deal?

In their research, Duman and others show that in a series of steps ketamine triggers release of neurotransmitter glutamate, which in turn stimulates growth of synapses.

So why not just take glutamine and riboflavin 5'-phosphate--an excellent activator of glutaminase in the brain? Glutaminase generates glutamate from glutamine, and there you are.

There are plenty of options.

I posted this more to document uses of a glutamate agonist, in general. There may be additional benefits for this method, in specific people with impaired neurotransmitter production. Studies needed..

[khemix]

Ketamine is an NDMA Glutamate receptor agonist though... so what good is the extra glutmate if it can't bind?

If antagonism causes a greater concentration of Glu, why not use memantine or magnesium instead?

[Psionic]

Ketamine is an NDMA Glutamate receptor agonist though... so what good is the extra glutmate if it can't bind?
If antagonism causes a greater concentration of Glu, why not use memantine or magnesium instead?

According to this study, blocking NMDA increases the activity of another receptor, AMPA, and this boost in AMPA activity is crucial for ketamine’s rapid antidepressant actions. NMDA and AMPA are receptors for the neurotransmitter glutamate. The glutamate system has been implicated in depression recently. This is a departure from previous thinking, which had focused on serotonin and norepinephrine. The glutamate system may represent a new avenue for treatment and research

http://www.nimh.nih.gov/science-news/2007/faster-acting-antidepressants-closer-to-becoming-a-reality.shtml

I wonder too what´s the difference between other NMDA antagonists like magnesium, rhynchophyline or memantine. And why they cant be used in similar way..

btw Nootropix you should look into your lifestyle, does exists any reason why you should be depressed?