8 replies to this topic

[bocor]

http://www.ncbi.nlm....pubmed/19796046
as well as another study i posted in the Epitalon thread.....Maybe just higher dosage is what is needed

[dear mrclock]

thought its some new study that you had urgency to share but seems old and irrelavent.
personaly, i dont see a reason to dose high on a neurohormone for any proposed beneficial health effects.

[hamishm00]

Paul Wakfer (http://www.morelife.org/) disagrees with you, looking at a recent regimen, his currently his daily dose is 30mg.

[dear mrclock]

30mg wow thats not a reasonable amount to suggest people take buddy

[niner]

From the paper bocor posted:

melatonin-treated (10 mg/kg melatonin, i.p. for 21 days)

If Paul Wakfer's going by this, then he must weigh three kg. If you metabolically scale the dose by the usual rat/human factor, then he'd be a portly 18kg. Even though he's on CR, he's still not hitting the dose in the paper. I wish they had done a dose-response experiment, so we could see if a human-feasible dose would have worked. On the other hand, melatonin is a funny compound- a lot of people have noticed that non-physiological doses are not as sleep-inducing as sub-milligram doses. What happens when a human takes a hundred milligrams of melatonin, anyway?

[Mind]

From the paper bocor posted:

melatonin-treated (10 mg/kg melatonin, i.p. for 21 days)

If Paul Wakfer's going by this, then he must weigh three kg. If you metabolically scale the dose by the usual rat/human factor, then he'd be a portly 18kg. Even though he's on CR, he's still not hitting the dose in the paper. I wish they had done a dose-response experiment, so we could see if a human-feasible dose would have worked. On the other hand, melatonin is a funny compound- a lot of people have noticed that non-physiological doses are not as sleep-inducing as sub-milligram doses. What happens when a human takes a hundred milligrams of melatonin, anyway?

Ask some of the posters in this thread, wow! Maybe they are still megadosing.

[blood]

From the paper bocor posted:

melatonin-treated (10 mg/kg melatonin, i.p. for 21 days)

If Paul Wakfer's going by this, then he must weigh three kg. If you metabolically scale the dose by the usual rat/human factor, then he'd be a portly 18kg. Even though he's on CR, he's still not hitting the dose in the paper. I wish they had done a dose-response experiment, so we could see if a human-feasible dose would have worked. On the other hand, melatonin is a funny compound- a lot of people have noticed that non-physiological doses are not as sleep-inducing as sub-milligram doses.

Hi niner,

What would be an equivalent human dose to the mouse dose of 10 mg/kg i.p.?

What happens when a human takes a hundred milligrams of melatonin, anyway?

I've been experimenting with 80-100 mg melatonin powder each night for the past several weeks. I was curious to see if it would help me lose abdominal/ visceral fat (a mouse study found that high doses of melatonin produced lean mice, who/ which experienced a loss of visceral fat). Subjectively, I haven't noticed anything much at all. My sleep is neither better or worse nor have I lost any abdominal flab. I do take a 5 mg sustained release melatonin tablet as well, to prevent any rebound awakening in the night a few hours following the mega dose of melatonin powder.

Edited by blood, 03 July 2013 - 07:57 AM.

[blood]

Is this person's hypothesising based on evidence from human studies? I can't see the full text.

http://www.medical-hypotheses.com/article/S0306-9877(10)00340-3/abstract

Potential of melatonin to treat or prevent age-related macular degeneration through stimulation of telomerase activity

Reza Rastmanesh

Faculty of Nutrition and Food Sciences, Dept. of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran

Received 29 May 2010; accepted 7 August 2010. published online 30 September 2010.

Abstract

Melatonin may play a causal role in the occurrence of age-related macular degeneration (AMD). Replicative capacity and response to injury in the retinal pigment epithelium (RPE) is compromised during aging. Prevention of telomere shortening by antioxidants may be a useful approach for reducing the cumulative effects of oxidative stress in RPE cells. Melatonin, a well known antioxidant, which acts advantageously as an amphiphilic agent, may benefit AMD patients more than commonly used lipophilic or hydrophilic antioxidants. It also may act through mechanisms other than antioxidant mechanisms because melatonin has receptors localized in the RPE, which act locally as a neurohormone and/or neuromodulator. Results of a clinical trial showed that 3mg melatonin given orally each night at bedtime for 3months to AMD patients reduced pathologic macular changes. I hypothesize that melatonin exerts additional benefit through down-regulating hTERT (catalytic subunit if telomerase) expression and stimulated telomerase activity in RPE, which subsequently helps to prevent or treat AMD. I suggest that melatonin therapy as pharmacologic agents and/or melatonin-rich foods, especially in AMD patients with measured low serum melatonin levels or high risk patients would be possibly an alternative approach to prevent and/or treat AMD. I suggest that melatonin has potential to prevent telomere shortening in RPE, while not precluding other mechanisms, namely antioxidative properties and/or restoration of inner blood-retina barrier (iBRB) integrity, reduced vascular endothelial growth factor (VEGF) and nitric oxide (NO) levels as well as leakage of horseradish peroxidase (HRP), inhibiting hypoxia-inducible factor-1alpha (HIF-1alpha) stabilization under hypoxia.

[PeaceAndProsperity]

Bump. I think I will test this (especially for eye sight) in an elderly relative of mine.