"...scientists are evaluating the most powerful of the healing factors of celery, a compound known as 3-nbutylphthalide or 3nB for short...
...3nB first drew significant scientific attention when researchers at the University of Chicago Medical Center identified it as the factor in celery responsible for the blood pressure lowering effect of celery.
...3nB appears to help lower blood pressure by both acting as a diuretic and vasodilator through impacting the production of prostaglandins
... 3nB has also been shown to lower blood cholesterol levels and reduce the formation of arterial plaque in experimental studies (animal and test tube studies).3,4 This effect may increase the elasticity of the blood vessels and also lead to lower blood pressure readings.
... 3nB also appears to promote some effects on areas and systems of the brain that control vascular resistance.
..celery extract acts as a diuretic but does not alter the ratio of sodium to potassium in the blood.
...celery extract has been shown to not only help prevent stroke in animal studies, but also improve blood flow as well and act to protect the brain and enhance energy production with the brain in a similar manner to Ginkgo biloba extract.5-8 It has produced dramatic recovery in neurological and brain function in animals in studies that simulate a stroke.6-10
...It has also been shown to significantly increase lifespan in animal studies.11...
...3nB has shown tremendous promise as an anticancer phytonutrient and detoxification aid in an experimental animal model,12
...its use as a pain reliever in arthritis, fibromyalgia, and gout that is getting most of the attention..."
References:
1.Le QT and Elliott WJ: Hypotensive and hypocholesterolemic effects of celery oil may be due to BuPh. Clin Res 1991;39:173A.
2.Tsi D and Tan BKH: Cardiovascular pharmacology of 3-n-butylphthalide in spontaneously hypertensive rats. Phytotherapy Research 1997;11:576-82.
3.Le QT and Elliott WJ: Dose-response relationship of blood pressure and serum cholesterol to 3-n-butylphthalide, a component of celery oil. Clin Res 1991;39:750A.
4.Mimura Y, Kobayashi S, Naitoh T, Kimura I and Kimura M:The structure-activity relationship between synthetic butylidenephthalide derivatives regarding the competence and progression of inhibition in primary cultures proliferation of mouse aorta smooth muscle cells. Biol Pharm Bull 1995;18:1203-6.
5.Yu SR, Gao NN, Li LL,Wang ZY, Chen Y and Wang WN:The protective effect of 3-butyl phthalide on rat brain cells.Yao Hsueh Hsueh Pao 1988;23:656-61.
6.Chong ZZ and Feng YP: dl-3-n-butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats. Chung Kuo Yao Li Hsueh Pao 1999;20:509-12.
7.Chong ZZ and Feng YP: dl-3-n-butylphthalide attenuates reperfusion-induced blood-brain barrier damage after focal cerebral ischemia in rats. Chung Kuo Yao Li Hsueh Pao 1999;20:696-700.
8.Yan CH, Feng YP and Zhang JT: Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats. Chung Kuo Yao Li Hsueh Pao 1998;19:117-20.
9.Lin JF and Feng YP: Effect of dl-3-n-butylphthalide on delayed neuronal damage after focal cerebral ischemia and intrasynaptosomes calcium in rats.Yao Hsueh Hsueh Pao 1996;31:166-70.
10.Liu XG and Feng YP: Protective effect of dl-3-n-butylphthalide on ischemic neurological damage and abnormal behavior in rats subjected to focal ischemia.Yao Hsueh Hsueh Pao 1995;30:896-903.
11.Zhang LY and Feng YP: Effect of dl-3-n-butylphthalide (NBP) on life span and neurological deficit in SHRsp rats.Yao Hsueh Hsueh Pao 1996;31:18-23.
12.Zheng G, Kenney PM, Zhang J and Lam KT: Chemoprevention of benzopyrene-induced forestomach cancer in mice by natural phthalides from celery oil. Nutr Cancer 1993;19:77-86.
13.Soundararajan S and Daunter B: Ajvine: Pilot biomedical study for pain relief in rheumatic pain. School of Medicine, The University of Queensland, Brisbane, Queensland, Australia, 1991-92.
14.Venkat S, Soundararajan S, Daunter B and Madhusudhan S. Use of Ayurvedic medicine in the treatment of rheumatic illness. Department of Orthopaedics, Kovai Medical Center and Hospitals, Coimbatore, India, 1995.
15.Hu D, Huang XX and Feng YP: Effect of dl-3-n-butylphthalide (NBP) on purine metabolites in striatum extracellular fluid in four-vessel occlusion rats.Yao Hsueh Hsueh Pao 1996;31:13-7
16.Chong ZZ and Feng YP: Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion. Chung Kuo Yao Li Hsueh Pao 1997;18:505-8.
http://www.myhealthm...515 Celery Seed
A novel compound from celery seed with a bactericidal effect against Helicobacter pylori.
http://www.ncbi.nlm....pubmed/19703351
