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Retin-A = ROS?


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#1 zonar

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Posted 25 November 2012 - 05:11 PM


Hey everyone, have been checking out this forum for quite some time, but think this is my first post here actually :)

Came across this study that links tretinoin to ROS production in vitro. Would be intereseting to hear what you guys have to say about it. Would switching to retin-a micro or another retinoid help?

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"The concentrations of
RA used in this study range from physiological plasma concentrations
to pharmacological concentrations. RA is present
constitutively in the plasma at a concentration of 4–14nM
[36]. Pharmacological RA doses result in transient plasma
concentration in the range of μM, the same doses at which
we observed TBARs formation and decreased cell viability."




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