i.e. a somatic, fully differentiated, fully committed, non-senescent, workers bee-type normal friggin cell ?
is there a single bloody word for it?
Many thanks
C. Annoyed
Posted 16 April 2005 - 10:04 PM
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Posted 19 April 2005 - 12:19 PM
caliban:their ability to divide
non-senescent
I think committed is pretty good. It says that it does not have a developmental choice, which is the key stem cell criterion.
Posted 19 April 2005 - 12:36 PM
Well, I think the difference is in the mechanism. Senescence would apply also to cells that perhaps should be dividing (e.g. they were stem cells), but due to safety mechanisms, their mitotic ability has been disabled. On the other hand, I wouldn't consider most of my brain cells senescent, even though they are post-mitotic.senescence describes an essentially irreversible arrest of cell division [Campisi]
thus
Post-mitotic = senescent ?
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