Hello
I'm came upon this study about Piperine, the main alkaloid in black/white pepper, said to constitute 5-10% of the mass of the actual spice.
http://www.ncbi.nlm..../pubmed/7168956
"Piperine effectively inhibited implantation, produced abortion and delayed labor when it was given from day 2 through 5, day 8 through 12 and day 15 until labor, respectively. At the same dose level which interrupts pregnancy, piperine did not affect the estrous cycle."
This study was on mice. Do you think this is a consideration for humans as well? Could heavy supplementation with pepper induce abortion?
Second study:
http://www.ncbi.nlm....erm=piperine t4
"The simultaneous administration of piperineand HFD (high-fat diet) significantly reduced plasma lipids and lipoproteins levels, except for HDL, which was significantly elevated. Piperine supplementation also improved the plasma levels of apo A-I, T3, T4, testosterone, and I and significantly reduced apo B, TSH, and insulin to near normal levels."
Do you think piperine supplementation can be used to increase thermogenesis and/or testosterone significantly?
I've also read studies indicating that piperine:
- Stimulates melanogenesis, production of melanin.
- Has MAO-A/B inhibitory activity.
- Inhibits Alpha-5 reductase, increasing testosterone and lowering DHT.
- Has neuroprotective effects on hippocampal neurons:
"In the present study, we demonstrated that the antidepressant-like effects of piperine and its mechanisms might be involved by up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity."
- Inhibits adipogenesis.
My main considerations are; would consuming a a few grams of pepper daily be beneficial for body-mass recomposition and boosting testosterone?
Is it plausable that piperine could prevent pregnancy in humans?
I am asking because I suspect people here might know more about its effect on biochemistry.
Edited by chung_pao, 14 December 2012 - 11:54 PM.
