25 replies to this topic

[dear mrclock]

i was going to ask people to report on coQ10 effetiveness in young people. whenever i read about its proposed benefits they seem to be related to the heart and overall energy and feeling of well being. i didnt see any reports of younger people using this supplement for energy tho. i have seen people taking it on this forum but im asking whats its effectiveness if you can supply some reports. i wonder if coQ10 actually helps someone who is young but has illness of some type. perhaps chronic fatigue syndrome benefit ? anyone has any idea if coQ10 might help in this regard ?










Edit: Removed reported topic tag.

Edited by Shepard, 29 December 2012 - 06:44 AM.

[Alphatrial]

What do you consider to be "young"?

[BDon]

I am also curious however I think Ubiq. is the potent form and you don't need more than 100mg? I read CoQ-10 helps with endurance?

[dear mrclock]

What do you consider to be "young"?

from what i read about coq10 is that, relates to "seniors". i dunno maybe 20s ? people have different variations of this. but yeh, someone in their 20s or 30s i might say.

I am also curious however I think Ubiq. is the potent form and you don't need more than 100mg? I read CoQ-10 helps with endurance?

thats what puzzles me. im trying to figure out if anyone uses it for endurance or they have noticed it helps with fatique or other issues like that. havent found any results from people taking it for this tho. only supposed cardiovascular health which i still didnt even find reliable report on being competent.

Edited by dear mrclock, 29 December 2012 - 12:58 AM.

[Alphatrial]

My girlfriend uses it (100 mg Ubiquinol). It gave it to her like a supplement (along with fish oil, D3, buffered Vit C powder and OPC). She has Lupus Erythematodes Profundus. I believe she got it from using Lamisil (Terbinafine), the pillform that is.

However.. I'm not sure whether it helps with the energy, but it sure helps with two other things:
1- migrain.. It appears to be (almost) gone;
2- sores in her mouth. Without Ubiquinol, it's terrible. With: no sores at all. I'm not sure what they are called in English, but it is a herpesvirus related sore.

Hope it's useful.

I'll ask her about the energy ;-)

[BDon]

Interesting.

[Alphatrial]

Oh! She's 38 by the way....

[Alphatrial]

I asked her about the energy: she answered: absolutely! So it seems to work ;-)

[dear mrclock]

My girlfriend uses it (100 mg Ubiquinol). It gave it to her like a supplement (along with fish oil, D3, buffered Vit C powder and OPC). She has Lupus Erythematodes Profundus. I believe she got it from using Lamisil (Terbinafine), the pillform that is.

However.. I'm not sure whether it helps with the energy, but it sure helps with two other things:
1- migrain.. It appears to be (almost) gone;
2- sores in her mouth. Without Ubiquinol, it's terrible. With: no sores at all. I'm not sure what they are called in English, but it is a herpesvirus related sore.

Hope it's useful.

I'll ask her about the energy ;-)

lol what you stated about your girlfriend here man.... disgusting. why is she your girlfriend anyway ?

Edited by dear mrclock, 30 December 2012 - 04:17 PM.

[Alphatrial]

It's not a herpes. It's something else. Strange reply by the way. Trying to help you out here. All you come up with is " disgusting". Dumb ass.

[mustardseed41]

My girlfriend uses it (100 mg Ubiquinol). It gave it to her like a supplement (along with fish oil, D3, buffered Vit C powder and OPC). She has Lupus Erythematodes Profundus. I believe she got it from using Lamisil (Terbinafine), the pillform that is.

However.. I'm not sure whether it helps with the energy, but it sure helps with two other things:
1- migrain.. It appears to be (almost) gone;
2- sores in her mouth. Without Ubiquinol, it's terrible. With: no sores at all. I'm not sure what they are called in English, but it is a herpesvirus related sore.

Hope it's useful.

I'll ask her about the energy ;-)

lol what you stated about your girlfriend here man.... disgusting. why is she your girlfriend anyway ?

WOW you really are the tool others say you are.

[Jembe]

I'm 26 and have been taking 100mg of ubiquinone a day for 20 days now. My report is highly anecdotal but I'd say I don't feel quite as tired on workout days. Don't get quite the same "lower gear" mode throughout the day after a morning session in the gym.

[BDon]

^ I'm interested in the CoQ-10. I was reading that too look into ~

Under the Age of 35: 100-200 mg of Ubiquinone once daily
Over the Age of 35: 100 mg of Ubiquinol CoQ10 has been an accepted supplement for our elders for many years now for its amazing results in slowing the age process.

[niner]

^ I'm interested in the CoQ-10. I was reading that too look into ~

Under the Age of 35: 100-200 mg of Ubiquinone once daily
Over the Age of 35: 100 mg of Ubiquinol CoQ10 has been an accepted supplement for our elders for many years now for its amazing results in slowing the age process.

This sounds like it comes from someone trying to sell ubiquinone/ol. When mice were given CoQ10 in a lifespan study, they didn't live longer than the control mice, in fact, they died a little bit sooner. I think these compounds have a place in the elderly and in people using statins. I don't think healthy people under 35 have any use for them, outside of particular medical conditions.

[Kevnzworld]

I would like to add that for those that take fish oil supplements ( PUFA's ), CoQ 10 supplementation,, preferably ubiquinol can be beneficial. It inhibits lipid peroxidation which can be a problem associated with higher dose fish oil supplementation.
" Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet "
http://www.sciencedi...531556503002687

It is also good for anyone with heart disease, especially early stage CHF.

[tunt01]

CoQ10 is standard therapy for young people (or any aged person) with mitochondrial disease/dysfunction. Obviously it is also used in in cardiac conditions, but also related issues that effect the cardiac system such as kidney disease.


http://miraclesformi...atment_2009.pdf

[niner]

Thanks Kevnzworld, that's very interesting, and not an effect I would have predicted. I don't recommend PUFAs, but if anyone chooses to OD on them, it's nice to know that there are interventions that can help (at least in rats, presumably humans too). Also good for CHF, as you mention. Ubiquinol made a big difference for my 92 year old father in law with early stage CHF.

[tunt01]

When mice were given CoQ10 in a lifespan study, they didn't live longer than the control mice, in fact, they died a little bit sooner.

I'd be curious to see that study. The literature I'm aware of shows it has no discernible effect on lifespan:

Example:

http://www.ncbi.nlm....pubmed/16443163

[niner]

CoQ10 is standard therapy for young people (or any aged person) with mitochondrial disease/dysfunction.
http://miraclesformi...atment_2009.pdf

Hey Pro, good to see you. Do you know anyone with a mitochondrial disease? After seeing a "throw away the crutches" response to c60-olive oil in a person with a statin-induced mitochondrial dysfunction, and in two other guys with respiratory inadequacy, I would add it to the toolkit mentioned in this article. For some people, it might be not just a little better, but an order of magnitude better than the traditional compounds.

[niner]

I'd be curious to see that study. The literature I'm aware of shows it has no discernible effect on lifespan:

It was probably five years ago. It might have been a slide from a presentation; I can picture it in my mind. It was a comparison of about four different interventions, showing the overlaid survival curves for each. I remember thinking: "hmm, that one sure sucks... let's see what that is... CoQ10. Well, guess I'll scratch that one off my list". In the paper you linked, the high dose, which was a real gigadose, looked like it was trending worse than control, but I guess it didn't reach significance. So maybe it's not terrible, but I think it's a waste of money for healthy young people.

[tunt01]

Do you know anyone with a mitochondrial disease? After seeing a "throw away the crutches" response to c60-olive oil in a person with a statin-induced mitochondrial dysfunction, and in two other guys with respiratory inadequacy, I would add it to the toolkit mentioned in this article. For some people, it might be not just a little better, but an order of magnitude better than the traditional compounds.

I don't know anyone with Mitochondrial Disease. But I came across Dr. Bruce Cohen's (mitchondrial disease expert) papers from Cleveland Clinic when I was looking at some mitochondrial related issues like Alzheimer's, etc.

I'm not up on the whole c60 craze that has gone on here. I just haven't had time to digest it all. I remember looking at that first study w/ the N=6 rat size studies and pretty much considered it a joke. I've just been too busy to read up on the new info that has transpired, but it's on my very long list of things to do.


hope you are healthy and well. have a good new year!

[nameless]

I may be remembering it wrong, but didn't LEF do a study on a whole bunch of compounds years ago, and CoQ10 was found to be of no benefit as far as longevity goes (or possibly it decreased rodent lifespan)? Actually nothing they studied showed any longevity benefits... I could be wrong -- but for some reason think LEF did that study.

CoQ10 and rodent studies may not correlate exactly anyway. Don't they primarily use CoQ9?

As for humans... unless you have a disease that benefits from CoQ10, or are elderly or taking statins, I am not sure there is much benefit to be gained. Perhaps a low dose could be warranted if over 30. I've been taking it for a while, but I have a weird heart. And I can not be certain really it has done a whole lot for me even.

If anyone is curious about CoQ10/Ubiquinol dosing, I did post a bunch of old threads here regarding serum levels at various doses... I think Ubiquinol resulted in basically a 2.5x increase over an equivalent CoQ10 dose as far as serum levels go. The lipid carrier + extras in the gel may have played a role too, so it may vary a little based on brands/forms used. The primary benefit for ubiquinol is if you need a higher serum level for some reason and simply wish to take less pills (or maybe if you are super elderly). I wouldn't suggest it for increasing longevity, or put much stock in LEF's old ubiquinol study -- the one with somewhat less decrepit-looking rodents taking ubiquinol.

Edited by nameless, 31 December 2012 - 05:55 AM.

[dear mrclock]

When mice were given CoQ10 in a lifespan study, they didn't live longer than the control mice, in fact, they died a little bit sooner.

I'd be curious to see that study. The literature I'm aware of shows it has no discernible effect on lifespan:

Example:

http://www.ncbi.nlm....pubmed/16443163

there was just a recent new study in January 2013 magazine of LEF. it did confirm CoQ10 extends lifespan.

grab it if you can, its free supposely. or maybe its on the site.

[nameless]

there was just a recent new study in January 2013 magazine of LEF. it did confirm CoQ10 extends lifespan.

Assuming I am looking at the same study you were, it's the study that Kevnzworld mentioned above. There potentially could be some CoQ10 benefits if consuming a high PUFA diet. I expect most people here aren't though.

[dear mrclock]

nameless, i just got this magazine for january 2013 from LEF, i assume its brand new study. but it has few pages detailing how it extends life.
and yeah, i consume 10 grams of fish oil at times because of my severe depression. its the only amount that works so i have no choice :(

[nameless]

Do you mean this article? http://www.lef.org/m...y-Factor_02.htm
This is the study they link to, regarding increasing longevity in rats --

1. Quiles JL, Ochoa JJ, Huertas JR, Mataix J. Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet. Exp Gerontol. 2004 Feb;39(2):189-94.

Same study listed above by Kevinzworld regarding PUFA intake. It was from 2004. The worm lifespan study was also from 2004.

Is the article/study you referring to different than one of those?

As for fish oil... yeah, I recall your fish oil thread. In it, I suggested you try 1g of EPA only in lieu of megadosing EPA/DHA.