WTF did I just read... If anything is causing brain damage it is this thread!
1. Correlation does not equal causation- it is plausible to believe the type of person who would shoot up a school is more likely to be exposed to psych meds.
2. The FDA committee achieved a consensus that sertraline was safe and effective for the treatment of major depression.
3. There are different subsets of receptors in the brain. Any talk of a chemical imbalance of serotonin regardless if it is for or against it probably is lacking in modern science and rather something from the New York Times or someones concerned mother.(Sorry mom love you!
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4. The brain is much more complex than mere stimulant or depressant a neurotransmitter can be both inhibitor or excitetitory depending on where in the brain.
5. Activation of one neuron causes a projection to other parts of the brain and therefore the activation of other parts of the brain and other chemical and hormonal changes.
6. just knowing what chemical it effects is way to vague to tell you much of anything cause the neurotransmitter can have very different functions depending on the subtype
7. Your brain talks in action potentials and chemical signaling everything "natural" ex a hot girl topless gets picked up by the senses and undergoes a process of transduction so your brain can understand it.
8. One proposed mechanism of how theses drugs work is by 5-ht2c downregulation as a result of agonizing the receptor site. This has been shown to be over expressed in the autopsied brains of many people who have committed suicide.
9. Another proposed mechanism is by stimulating neurogenesis helping the brain create new nerve cells. Providing neuroprotection and helping the formation of new pathways.
10. Also, increasing levels of BDNF which is quite popular here e.x. noopept lions mane just to name a few.
11. By providing a anti-inflammatory effect. Now we are starting to see that in causes of depression some people may be experiancing a proinflammitory effect in the brain.
12. Yet more evidence for SSRIS is perhaps by decreasing the over exp
ression of 5-ht2a receptors in the brain. Some evidence suggests in deceased depressed patients they had a higher exp
ression of this receptor than a normal person.
13. Even in the evident two drugs share a receptor subtype binding that does not mean they will do the same thing. For example lsd ginko seroquel tramadol and dmt all bind to the 5-ht1a receptor subtype but have very different effects. This is really complex but the next point shows one reason how this can be possible.
14. Depending on drugs binding affinity they can have very different effects a example would be coke being euphoric while wellbutrin not being so even though they both are dopamine transporter inhibitors due to the difference it binding resulting in a ~20% (i dont recall off the top of my head) vs the what is believe to be about 65% or greater to achieve prominent recreational effects.
15. Analysis of national mortality files shows 458 deaths occur each year from acetaminophen-associated overdoses; 100 of these are unintentional in the USA (pubmed) vs New figures from the Office for National Statistics show there were 17.6 deaths among users for every million prescriptions written for Efexor and similar types of anti-depressant between 1993 and 2002. This compares with a rate of 4.3 deaths per million prescriptions for anti-depressants such as Prozac. Lets keep things in perspective rather than paying more attention to the deaths burned deeply into our brain via hitting our amygdala causing vivid recall and representation in our brain and being overly represented in the media due to it being more interesting and graphic and can easily open up into mind control Orwellian religion and philosophy based pseudoscientific endless rants.
