I've seen huge improvements in my condition - psoriasis. The wide ranging of epigenetic effects that curcumin ehibits is astounding. It is not only a histone deacetylase inhibitor, but also a DNA hypomethylating agent.
See - Curcumin as a regulator of epigenetic events, Marie-Hel´ene Teiten et al, Mol. Nutr. Food Res. 2013, 57, 1619?1629
In this recent paper paid for by the German government, theracurmin had good bioavailability (27 fold), as did the piperine group did well too (20 fold) and BCM-95 (7 fold). Of course all the commercially available forms were all beaten my their micronized powder and liquid micelles. I wish I knew whether that was available.
Schiborr, C. et al, The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol. Nutr. Food Res. (2014), 58: 516?527. doi: 10.1002/mnfr.201300724
"The use of adjuvants, such as piperine [28] or turmeric essential oils [37], enhanced curcumin bioavailability (based on AUC) 20- or 7-fold, respectively (Table5). Incorporation of curcumin into lecithin (mainly phosphatidylcholine) liposomes resulted in a ca. fourfold better absorption (based on AUC) than native curcumin in nine healthy volunteers [38]. The bioavailability of a micronized form of crystalline curcumin (Theracurmin, prepared from curcumin, ghatti gum, and water), compared to native curcumin, was 27-fold increased (Table 5) [39]. Thus, our micellar delivery system, which enhanced curcumin bioavailability 185-fold (all subjects), appears to be superior to all hitherto tested formulations, while our micronisate (ninefold increase in AUC) is similarly effective as previously reported strategies (Table 5). Furthermore, the Cmax achieved with a single oral dose of 410 mg curcumin from our micellar formulation (women, 3.7 ?mol/L; men 2.6 ?mol/L) are higher than those observed after the intake of 8 g of native curcumin [31].
The present study revealed sex differences with respect to the plasma AUC of curcumin. Women absorbed curcumin to a larger extent (higher Cmax and AUC) than men (Table 2). This could be due to the reportedly higher expression and activity of the hepatic drug efflux transporter P-glycoprotein (MDR1) and some isoforms of the glucuronosyltransferases and sulfotransferases, enzymes involved in curcumin biotransformation, in men [47]. However, the differences in bodyweight (Table 1), blood volume, and body fat, which ultimately lead to smaller volumes of distribution in women, may also account for the observed differences [47].
Less than 0.2% of the oral dose of curcumin was excreted with urine within 24 h. Thus, >98.8% of the ingested curcumin was either excreted via the bile and feces or may have been distributed to body tissues where it may potentially exert biological activities.
Free curcumin concentrations as low as 100 nmol/L reversed disease state and reduced IL-1? in Alzheimer's disease models [48, 49], therefore our newly developed curcumin formulations may be suitable vehicles for the delivery of pharmacologically relevant doses of the phytochemical in human intervention trials."
Edited by Phoenicis, 29 May 2014 - 06:54 PM.
