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(NAC) 2013 Safety Update

nac safety

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#31 moleface

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Posted 10 March 2013 - 02:56 PM

I've been taking 2400mg a day for OCD for the past year, and I've noticed no obvious problems from this dose. It might be the placebo effect, but I think I've noticed something like a 20% decrease in my involuntary OCD thought loops since I started taking this amount.

The main reason I started NAC was for its antioxidant effects though. I used to abuse my body for years and I also only recently found out that I have celiac disease after I developed severe arthritis symptoms and lost a ton of weight rapidly, so I'm trying to counter years of severe stress on my system.

I can't afford a lot of different antioxidant supplements, so I've come up with a synergistic combination of three inexpensive common antioxidants - 1200mg egcg 2x a day, 3-5g of vitamin c 2x a day, and 600mg EGCG once daily. Staying on this protocol has led to a remarkable decrease in my once-debilitating joint inflammation. This time last year, my joints were in so much pain that I could hardly type, and I also developed iritis - mindblowingly painful eye inflammation. Along with following a strict gluten free diet, these supplements have done a lot to give me back my health.

I'm also hoping that it works as a cancer preventative to offset the years of heavy cigarette smoking and the increased risk of cancer that comes with celiac disease.

"The combination of NAC and EGCG caused an 8.8-fold increase in apoptosis in CL13 mouse and H1299 human lung cancer cells compared to treatment with either agent"

http://www.ncbi.nlm....les/PMC2366886/

#32 guitarparty

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Posted 11 March 2013 - 09:07 AM

I was diagnosed with Pulmonary Hypertension last year and also have suffered some from a bit of asthema. The Pulmonary Hypertension was diagnosed on the basis of what the pulmonary specialist saw on one heart sonagram. However, the picture on the second type of sonagram wasn't a good one and couldn't either support or dispute the diagnosis, so there is some little bit of question about the diagnosis. Anyway, I don't think my Pulmonary Hypertension is very bad at this point, because when I'm not feeling the pain in my chest that feels like the breath being sucked out of me, my oxygen levels have all been fine, except for one time in a hospital emergency room when it went down to 89 after the administration of some IV narcotics. (...which was a terrible idea that brought on severe nausea, but I wasn't asked for an opinion at the time. This was for what turned out to be shingles and I shouldn't have gone to the hospital at all for it, but as soon as I mentioned "chest pain" on the phone my doctor's office wouldn't see me.) Anyway, I don't have that attention-getting breath-sucking pain in my chest most of the time and I haven't quite figured out how to predict what causes it to come on, beyond periods of heavy stress. The only thing I'm really sure about is that it's going to appear sometimes no matter what supplements I might be taking at the time.

Anyway, this breath-sucking thing was the situation for me prior to trying out NAC (at the 600 mg. level daily). As nearly as I recall, my problems with having the feeling of the breath being sucked out of my chest along with chest pain came no more frequently with NAC than prior to starting NAC. The numbers of problem times might even have improved, in fact, because with a change in diet my diabetes has been in better control and I'm feeling a little bit better overall.

I took NAC for a couple of months. The reason I tried it was because of a horrible mucous problem from my head to my chest that was leftover from catching something last fall I was having a bunch of trouble getting over. If that mucous problem ever happens again to that extent, I'd take NAC again in a flash. I think it's a good idea to have that supplement on hand in case you catch the flu (or whatever).

The reason I stopped NAC was because I was beginning to wonder whether it might be contributing to making one of my longstanding problems with allergies worse: a continuing extreme problem with what appears to be a bacterial sinus infection-- but which I once had a bunch of efforts at wiping out via antibiotics. That approach only worked a short while before the problem returned. What comes out of my nose does look like a bacterial infection, but it fairly regularly has blood mixed in with it. But doing what the Ear Nose Throat specialist instructed--use of Neosporin on a Q-tip--hasn't made a dent in affecting the problem. Sometimes the nasal bleeding problem is a gusher kind of thing. The main thing I know is that antihistamines do tend to help some, at least a little bit, so I think allergies are involved in perpetuating the problem. It feels like a nose and a head that are badly stuffed up, as if you've just caught a terrible cold. After starting on NAC, when the problem got worse (a few times when I went back onto NAC after a short period off), I began to suspect an allergy relationship with NAC. (Nothing new in that--my medical history is replete with eventual reactions to all sorts of foods, supplements, and pharmaceuticals that initially caused no problems at all but eventually went haywire on me.)

Anyway, all three of my supplement books give a high thumbs-up for NAC. The newest was written by three MD's--psychiatry medical professors, and they say that any potential worries with this drug are "minimal at appropriate dosages." If it suits them to recommend NAC's usage to their medical students, it suits me too. I know of no reason not to recommend trying it at something in the neighborhood of 600 mg/day if it might help whatever is ailing you.

Best wishes, Mary
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#33 niner

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Posted 11 March 2013 - 01:25 PM

"The combination of NAC and EGCG caused an 8.8-fold increase in apoptosis in CL13 mouse and H1299 human lung cancer cells compared to treatment with either agent"

http://www.ncbi.nlm....les/PMC2366886/


This was an in vitro experiment where cells were bathed in 100uM EGCG and 1000-2000uM NAC for 48 hours. To reach levels like that in vivo would require dangerously high if not lethal doses of both compounds. It's probably not going to be a significant interaction at normal doses, although taking the two together isn't likely to be harmful.
  • Agree x 1

#34 RJ100

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Posted 11 March 2013 - 01:41 PM

I took NAC for over a year to help my OCD and to try and raise glutathione in my brain. I believe it did help, but I also believe it chelated the hell out of my body's minerals and also possibly caused some intestinal problems with the thinning of my mucus membranes. I've dropped it for the time being.

#35 mikeinnaples

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Posted 11 March 2013 - 02:06 PM

So how exactly does NAC work in regards to all of these chelation concerns people are citing? Is it only binding to 'free' copper, mercury, ect. ? So if you take NAC away from meals you won't interfere with normal mineral use, kind of like how you should take IP6?

#36 renfr

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Posted 11 March 2013 - 04:30 PM

Now that everyone is talking about having intestinal problems, well I have to admit that this week I started about having some intestinal issues.
The best I can describe this is a shakes within my intestines that I can feel, the same kind of intestinal shakes you get from taking a bit too much coffee. And also increased gas.
This is not impairing however I wonder if this could mean something more serious, maybe copper deficiency causing this?
It would terribly annoy me to stop NAC because it has been a wonder supplement for me and I can't just afford liposomal glutathione...
Maybe I should just supplement high copper foods and see what it does...

#37 moleface

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Posted 11 March 2013 - 10:48 PM

"The combination of NAC and EGCG caused an 8.8-fold increase in apoptosis in CL13 mouse and H1299 human lung cancer cells compared to treatment with either agent"

http://www.ncbi.nlm....les/PMC2366886/


This was an in vitro experiment where cells were bathed in 100uM EGCG and 1000-2000uM NAC for 48 hours. To reach levels like that in vivo would require dangerously high if not lethal doses of both compounds. It's probably not going to be a significant interaction at normal doses, although taking the two together isn't likely to be harmful.


Right you are. I read that study a couple years ago, and I completely forgot that it wasn't an in vivo study when I posted it.

From what I understand, in vitro studies are only useful for showing that a compound has potential anti-cancer activity that can't necessarily be extrapolated to real-world conditions. Too bad.

#38 moleface

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Posted 11 March 2013 - 10:56 PM

About intestinal issues -

I haven't noticed anything like that, but then again I have confirmed celiac disease. I only went gluten free a little over a year ago, and my intestinal problems have improved but not gone away entirely. My celiac was severe and culminated in massive weight loss (I was 130lb at 6 foot 1), giant missing chunks of tooth enamel, and debilitating arthritis symptoms, so it may just be that it's going to take longer than a year for my intestines to fully recover. Now I'm wondering if the NAC might be the reason why I'm still having some issues in that area. I'm going to try dropping the NAC for a few days to see if I see any marked improvement.

I also get the most horrific rotten egg gas of all time, and it's definitely occurred to me that the sulfuric NAC might have something to do with that. This is an unspeakable odor - it's the sort of smell that's so vile that I'm ashamed my body is even capable of producing such a smell. I'd hate to have to choose between OCD or having gas problems worthy of mention in a medical textbook.

Edited by moleface, 11 March 2013 - 10:56 PM.


#39 hamishm00

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Posted 12 March 2013 - 06:29 AM

From my own recent experience, I think long term NAC use is an issue. Started getting itchy skin and a mild allergic response that was persisting for over a month, as well as mild ulcers which have come and gone for the last year (probiotics, colostrum, FOS, inulin, all helping to fix the ulcer feeling when it happened). Fearing leaky gut syndrome and/or copper deficiency, I dropped NAC for a week and all these symptoms have now dissipated. There has been a definite improvement in intestinal fortitude.

It's probably a good idea to take breaks from NAC supplementation from time to time.

#40 renfr

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Posted 12 March 2013 - 07:04 AM

Any study that links NAC to leaky gut syndrome?
As far as I have researched, NAC serms to be in fact advised against LGS.
I do have the sulfur gas problem and some gut problems, is too much sulfur a bad thing?


#41 renfr

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Posted 12 March 2013 - 07:12 AM

Some of the side effects of too much sulfur are:

-Neurological effects and behavioral changes
- Disturbance of blood circulation
- Heart damage
- Effects on eyes and eyesight
- Reproductive failure
- Damage to immune systems
- Stomach and gastrointestinal disorder
- Damage to liver and kidney functions
- Hearing defects
- Disturbance of the hormonal metabolism
- Dermatological effects
- Suffocation and lung embolism
- Swelling of extremities

Not sure if NAC is enough to cause all that, it usually occurs when there's sulfur overload but from the testimonies on this thread there are some symptoms from NAC induced high sulfur :
- Swelling of extremities
- Dermatological effects
- Suffocation
- Gastrointestinal disorder
- Immune system disorder

#42 renfr

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Posted 12 March 2013 - 02:15 PM

I was concerned about some phantom pain in my finger, I had no lesion no wound and yet it was painful, if I touched the painful area it didn't make it more painful.
After some research I found that this was peripheral neuropathy and mostly due to B12 deficiency, I downed a B vitamin complex with 500% RDA B12 and the pain disappeared within one hour.
I found out that NAC increases B12 excretion, not a good thing :/
Now I know copper and B12 should be supplemented with NAC, anyone knows about any other deficiency NAC may cause?

#43 renfr

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Posted 12 March 2013 - 02:23 PM

http://forums.phoeni...nted-b12.13860/
About NAC and B12, from what I understand excess glutathione is bound to B12 therefore maybe taking high doses of NAC is useless, what do you guys think?
I only did 400mg for 1.5 month, now I upped to 700mg because I capped it due to its foul rotten egg taste but I guess I'll take it once every two days.
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#44 mikeinnaples

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Posted 12 March 2013 - 02:46 PM

Hmm, I have noticed nothing negative from my NAC usage over the years.Nothing of note in any labwork either.

Maybe it because of when I take it? NAC, IP6, Melatonin, and Silymarin I take right before bed... the first two to not interfere with mineral absorption from meals with the hopes that maybe excess is getting remove (iron and IP6 for example).

#45 renfr

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Posted 12 March 2013 - 03:03 PM

Good idea, it seems that taking it with food is even counterproductive as its absorption gets significantly reduced...
Will take it at night on empty stomach, I hope this definetely resolves this issue.

#46 Kevnzworld

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Posted 12 March 2013 - 03:32 PM

Hmm, I have noticed nothing negative from my NAC usage over the years.Nothing of note in any labwork either.

Maybe it because of when I take it? NAC, IP6, Melatonin, and Silymarin I take right before bed... the first two to not interfere with mineral absorption from meals with the hopes that maybe excess is getting remove (iron and IP6 for example).


I take 600 mg in the late morning between meals. Like mikeinnaples I have never experienced anything negative which I could attribute to NAC.

#47 niner

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Posted 12 March 2013 - 06:02 PM

Now that everyone is talking about having intestinal problems, well I have to admit that this week I started about having some intestinal issues.
The best I can describe this is a shakes within my intestines that I can feel, the same kind of intestinal shakes you get from taking a bit too much coffee. And also increased gas.
This is not impairing however I wonder if this could mean something more serious, maybe copper deficiency causing this?
It would terribly annoy me to stop NAC because it has been a wonder supplement for me and I can't just afford liposomal glutathione...
Maybe I should just supplement high copper foods and see what it does...


Your symptoms sound exactly like something I had a number of years ago, which was diagnosed as Irritable Bowel Syndrome. This is very common and can certainly occur without NAC, so NAC may or may not be responsible. The usual things you would do to improve gut health should be tried- probiotics and fiber would be a place to start. You could try a break from NAC to see if things suddenly get better.

#48 RJ100

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Posted 12 March 2013 - 07:28 PM

Taking a break from NAC is all I'm doing. I'm not trying to convince anyone to drop NAC if they feel they're having success with it.

#49 HeyItsMeLC

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Posted 12 March 2013 - 08:13 PM

Found this from an Acetaminophen overdose brochure. They do mention its effect on the gastrointestinal track.

On the other hand, 140mg/kg as a loading dose! Thats ALOT OF NAC. So, for a 80kg man that would be 11g+ as initial dose, then 5600mg every 4 hours for 17 doses.

Let me bring out my calculator, 24 hours / 4 = 6 doses of 5600mg. Factoring in the initial loading dose that would be almost 40GRAMS in a day. Like I said, thats ALOT of NAC.


Oral NAC
The FDA approved oral dosing regimen is 140 mg/kg as the
loading dose, then 70 mg/kg every 4 hours for 17 doses
starting 4 hours after the loading dose. Oral NAC is irritating
to the gastrointestinal track and should be diluted to a final
concentration of no more than 5% to reduce the risk for
vomiting. The oral form of NAC has an unpleasant odor and
taste that can also affect compliance with administration.

http://uuhsc.utah.ed...ox/Vol7_No1.pdf

#50 guitarparty

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Posted 13 March 2013 - 03:50 AM

Good idea, it seems that taking it with food is even counterproductive as its absorption gets significantly reduced...
Will take it at night on empty stomach, I hope this definetely resolves this issue.


I had a problem in taking NAC on an empty stomach: definite digestive upset, though it wasn't horrible.

Best wishes, Mary

#51 guitarparty

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Posted 13 March 2013 - 04:50 AM

Your symptoms sound exactly like something I had a number of years ago, which was diagnosed as Irritable Bowel Syndrome. This is very common and can certainly occur without NAC, so NAC may or may not be responsible. The usual things you would do to improve gut health should be tried- probiotics and fiber would be a place to start. You could try a break from NAC to see if things suddenly get better.


Hi Niner,

I'm not close to being an expert in this area, though it's one I'm desperately trying to deal with now. This was my initial incentive to make huge diet changes (that appear to be helping).

There's a book by Wayne Persky that I'd recommend: "Microscopic Collitis." In this book, Wayne argues against fiber as soothing to inflamed intestines. He also cites a study that would make any sufferer avoid using FOS.



I only went gluten free a little over a year ago, and my intestinal problems have improved but not gone away entirely. [...] I also get the most horrific rotten egg gas of all time.



Hi Moleface,

As Wayne Persky discusses in his book, lots of people have more foods to avoid than just glutens in an effort to help heal the gut. Just avoiding glutens doesn't mean that you don't have additional problems with other proteins. You're not likely to fully heal without addressing all the problems you might have.

After gluten, the next most likely problem area (for very large numbers of people) is with the protein in dairy foods. Most people who have to avoid glutens also usually end up having to steer clear of all diary foods with their casein proteins. About half of those gluten & casein reactors also have to avoid soya, and most of that half also have to avoid all legumes. That's where I am right now... avoiding all that stuff that I was once tested allergic to. I'm just hoping that I don't end up with a tree nut problem, now that I've dropped so many foods that I'm eating within a very narrow selection of foods now. I do recall that in my allergy testing long ago (allergic to 66 foods), I had one or two tree nut allergies, as well as almost every fish and shellfish. I think I was tested allergic to walnuts then, though it was so long ago and I ignored all that allergy info for so many years that it's hard to recall exactly.

I'm very familiar with the odor you describe, and I was very familiar with that awful odor for _years_ before I ever tried NAC. If you're still getting that peculiar odor, you might consider trying to go off ALL dairy products in general, and see whether things don't start to get better. I hope you don't end up finding that you also have a problem with soya, because that's a big problem for having full choices in supplements. As I recall from my testing, I'm allergic to all beans except for green beans and soya. I'm trying to avoid soya where possible, because I don't know that I haven't acquired a problem there since then too.

If you end up wanting to get tested, the place Wayne Persky recommends is Enterolab in Texas. I don't have their address, but you could probably find it by searching on Wayne's website (perskyfarms).

Best wishes, Mary
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#52 renfr

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Posted 13 March 2013 - 07:46 AM

Hmm, I have noticed nothing negative from my NAC usage over the years.Nothing of note in any labwork either.

Maybe it because of when I take it? NAC, IP6, Melatonin, and Silymarin I take right before bed... the first two to not interfere with mineral absorption from meals with the hopes that maybe excess is getting remove (iron and IP6 for example).

In fact taking it before bed is not a good thing, a pharmacist told me taking it a night will cause mucus congestion in the throat which is unpleasant. It does occur to me when I lay in bed.

Now that everyone is talking about having intestinal problems, well I have to admit that this week I started about having some intestinal issues.
The best I can describe this is a shakes within my intestines that I can feel, the same kind of intestinal shakes you get from taking a bit too much coffee. And also increased gas.
This is not impairing however I wonder if this could mean something more serious, maybe copper deficiency causing this?
It would terribly annoy me to stop NAC because it has been a wonder supplement for me and I can't just afford liposomal glutathione...
Maybe I should just supplement high copper foods and see what it does...


Your symptoms sound exactly like something I had a number of years ago, which was diagnosed as Irritable Bowel Syndrome. This is very common and can certainly occur without NAC, so NAC may or may not be responsible. The usual things you would do to improve gut health should be tried- probiotics and fiber would be a place to start. You could try a break from NAC to see if things suddenly get better.

Yogurt definetely helps even though I'm reluctant to it, however it probably wasn't the NAC itself, maybe it was the brand or the coffee from the other day because this hasn't occured again.

Good idea, it seems that taking it with food is even counterproductive as its absorption gets significantly reduced...
Will take it at night on empty stomach, I hope this definetely resolves this issue.


I had a problem in taking NAC on an empty stomach: definite digestive upset, though it wasn't horrible.

Best wishes, Mary

It's probably due to its acidity, if you try the powder you will see how horrible this stuff tastes.


Just found this, is this bogus? (see attached file)

Attached Files

  • Attached File  dna.jpg   16.89KB   10 downloads


#53 mikeinnaples

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Posted 13 March 2013 - 12:23 PM

In fact taking it before bed is not a good thing, a pharmacist told me taking it a night will cause mucus congestion in the throat which is unpleasant. It does occur to me when I lay in bed.


While I do have a deviated septum as well as allergies this time of the year, I do not have what you mention as a NAC symptom. I take the Jarrow NAC that is half immediate release and half slow release 5 days a week.

Edited by mikeinnaples, 13 March 2013 - 12:24 PM.


#54 moleface

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Posted 13 March 2013 - 04:41 PM

Your symptoms sound exactly like something I had a number of years ago, which was diagnosed as Irritable Bowel Syndrome. This is very common and can certainly occur without NAC, so NAC may or may not be responsible. The usual things you would do to improve gut health should be tried- probiotics and fiber would be a place to start. You could try a break from NAC to see if things suddenly get better.


Hi Niner,

I'm not close to being an expert in this area, though it's one I'm desperately trying to deal with now. This was my initial incentive to make huge diet changes (that appear to be helping).

There's a book by Wayne Persky that I'd recommend: "Microscopic Collitis." In this book, Wayne argues against fiber as soothing to inflamed intestines. He also cites a study that would make any sufferer avoid using FOS.



I only went gluten free a little over a year ago, and my intestinal problems have improved but not gone away entirely. [...] I also get the most horrific rotten egg gas of all time.



Hi Moleface,

As Wayne Persky discusses in his book, lots of people have more foods to avoid than just glutens in an effort to help heal the gut. Just avoiding glutens doesn't mean that you don't have additional problems with other proteins. You're not likely to fully heal without addressing all the problems you might have.

After gluten, the next most likely problem area (for very large numbers of people) is with the protein in dairy foods. Most people who have to avoid glutens also usually end up having to steer clear of all diary foods with their casein proteins. About half of those gluten & casein reactors also have to avoid soya, and most of that half also have to avoid all legumes. That's where I am right now... avoiding all that stuff that I was once tested allergic to. I'm just hoping that I don't end up with a tree nut problem, now that I've dropped so many foods that I'm eating within a very narrow selection of foods now. I do recall that in my allergy testing long ago (allergic to 66 foods), I had one or two tree nut allergies, as well as almost every fish and shellfish. I think I was tested allergic to walnuts then, though it was so long ago and I ignored all that allergy info for so many years that it's hard to recall exactly.

I'm very familiar with the odor you describe, and I was very familiar with that awful odor for _years_ before I ever tried NAC. If you're still getting that peculiar odor, you might consider trying to go off ALL dairy products in general, and see whether things don't start to get better. I hope you don't end up finding that you also have a problem with soya, because that's a big problem for having full choices in supplements. As I recall from my testing, I'm allergic to all beans except for green beans and soya. I'm trying to avoid soya where possible, because I don't know that I haven't acquired a problem there since then too.

If you end up wanting to get tested, the place Wayne Persky recommends is Enterolab in Texas. I don't have their address, but you could probably find it by searching on Wayne's website (perskyfarms).

Best wishes, Mary


Thanks for the helpful info!

I've definitely considered giving up casein, but I only have 150-200 dollars a month to spend on food and my dietary choices as a celiac are extremely limited. I eat the exact same thing every day - fruits mixed into a smoothie with inexpensive egg soy and whey protein powder(the likely culprit of my continuing intestinal issues), leafy greens, peanut butter, and kidney beans mixed with brown rice. I LOVE food and it sucks to never eat anything else(especially when running 4-5+ miles a day makes me absolutely ravenous), but this stuff covers my dietary needs along with the el cheapo Swanson antioxidants I only spend about $15 a month on to help fill in nutritional gaps.

I'm honestly not sure what I'd do if I couldn't eat beans or the protein powder - those were both inexpensive compromises to begin with. Meat isn't as economical, and with the help of the concentrated protein powder I'm definitely getting all my essential amino acids. The amount of these two foods I eat a day only comes to about $1.00, whereas even a half-spoiled steak from the meat clearance rack would set me back at least $3. I might try switching over to brown rice protein powder instead, though I'm still not sure what I could replace the beans with. They're just about the only food in my current diet that's even remotely filling.

The Swanson vitamins could be the issue as well, seeing as the company refuses to officially confirm their products as gluten free. The ingredients show nothing that should be a problem, aside from cellulose - and apparently wheat cellulose doesn't even contain the gluten proteins.

This problem is made all the more puzzling by the fact that I had absolutely no intestinal issues for about a six month period after the initial hellish month of detoxing from gluten. Then they mysteriously started up again this past autumn and they're now debilitating. First I have constipation, then it turns into repeated severe diarrhea attacks for the first several hours of every single day. It's hard to live a normal life while dealing with problems like this.

I'm getting a PHD in school, but until then I won't have any disposable income whatsoever. Once I finally graduate and get a decent job, I intend to get a full battery of allergen tests done.

Edited by moleface, 13 March 2013 - 04:45 PM.


#55 HeyItsMeLC

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Posted 13 March 2013 - 09:08 PM

Found this, thought it was interesting...

Posted Image


The promise of N-acetylcysteine in neuropsychiatry
Trends in Pharmacological Sciences, Volume 34, Issue 3, 167-177, 29 January 2013


Summary

N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of NAC overlap with known pathophysiological elements, and offers a précis of current literature regarding the use of NAC in disorders including cocaine, cannabis, and smoking addictions, Alzheimer's and Parkinson's diseases, autism, compulsive and grooming disorders, schizophrenia, depression, and bipolar disorder. There are positive trials of NAC in all these disorders, and although many of these require replication and are methodologically preliminary, this makes it one of the most promising drug candidates in neuropsychiatric disorders. The efficacy pattern of NAC interestingly shows little respect for the current diagnostic systems. Its benign tolerability profile, its action on multiple operative pathways, and the emergence of positive trial data make it an important target to investigate.


(This was in the concluding remarks...)
There are several caveats that need to be borne in mind. As the database increases, it is likely to be that the profile of efficacy of NAC will be greater in some disorders than others. The optimal dose of NAC is not clear; dose-finding studies may show equal efficacy at lower doses or greater efficacy at higher doses. Although the tolerability profile of NAC seems benign, there is as yet an insufficient evidence base for longer term use. Idiosyncratic events, such as asthma, have been shown in some studies, but not replicated, and pulmonary hypertension at very high dose has been reported in a few animal studies, but, as yet, has not been found in human studies [118]. At low dose NAC appears to be anti-epileptic [119], but at high doses seizures have been reported [120]. Hence, ongoing data collection regarding safety is necessary, concomitant with corroborating efficacy data.

For the full text, see here:
http://www.cell.com/...t/S0165-6147(13)00002-3

Edited by HeyItsMeLC, 13 March 2013 - 09:11 PM.


#56 guitarparty

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Posted 14 March 2013 - 02:01 AM

Just found this, is this bogus? (see attached file)


Hi Renfr,

I have a vague recollection of having seen that file somewhere on this website previously. But it's not mine and I didn't post it.

Best wishes, Mary

#57 guitarparty

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Posted 14 March 2013 - 11:00 AM

I've definitely considered giving up casein, but I only have 150-200 dollars a month to spend on food and my dietary choices as a celiac are extremely limited. I eat the exact same thing every day - fruits mixed into a smoothie with inexpensive egg soy and whey protein powder(the likely culprit of my continuing intestinal issues), leafy greens, peanut butter, and kidney beans mixed with brown rice. I LOVE food and it sucks to never eat anything else(especially when running 4-5+ miles a day makes me absolutely ravenous), but this stuff covers my dietary needs along with the el cheapo Swanson antioxidants I only spend about $15 a month on to help fill in nutritional gaps.


I'd suggest giving up dairy totally for the next couple of weeks before trying to move forward with anything else. That might do the trick, or it might take a little bit longer to know whether it's getting better or not. If you decide it's definitely getting better, give it several more weeks and decide whether it's getting better fast enough to figure that your gut is going to eventually completely heal that way.

Almost everyone who has a problem with cow's milk and cow dairy products also has a problem with beef. I'm pretty sure that if you find yourself having a problem with diary proteins, you also need to strictly avoid beef. That would be the next thing to give up if giving up dairy doesn't work sufficiently well (assuming you once in awhile have some beef).

Having lamb when/if you can ever afford it is a good beef alternative. Few people have issues with lamb. Whether that's because of its cost--so you've never had it on a basis close to everyday, thus not increasing the exposures--or maybe because it has no relationship to drinking cow's milk--or something else about its chemistry--I don't know. I just know it's relatively safe for most people with digestive problems. Pork is less likely than beef to bring a problem too, but more so than chicken and turkey are. You might also have a problem with eggs; that's more likely than for pork but less likely than beef. (I'm remembering this from long ago with my testing, where the reporting sheet went down the line in order of the probabilities taken from stats on a large US population. Divided into 3 columns on one sheet, I think I recall that eggs were in the first column and pork was in the second.)

I'm honestly not sure what I'd do if I couldn't eat beans or the protein powder - those were both inexpensive compromises to begin with. Meat isn't as economical, and with the help of the concentrated protein powder I'm definitely getting all my essential amino acids. The amount of these two foods I eat a day only comes to about $1.00, whereas even a half-spoiled steak from the meat clearance rack would set me back at least $3. I might try switching over to brown rice protein powder instead, though I'm still not sure what I could replace the beans with. They're just about the only food in my current diet that's even remotely filling.


Brown rice powder is _low_ on protein.

The two most affordable sources of protein, if you can't eat soy or beans, would be eggs or chicken on sale. But as a first step (if simply avoiding dairy and beef doesn't work), try just eliminating the soy only for a couple of weeks; you'd still have beans left as your major source of protein that way. Only if that doesn't work, you'd need next to go on to eliminating all beans.

I have never been a believer in limiting egg consumption because of cholesterol, and I think the more recent research doesn't back up the idea of limiting yourself on eggs either. You could hardboil something like 8 eggs at one time in your largest pan, making sure you don't overdo it (edge of yolk will turn grey if you do that), cool them a bit in water, and refrigerate what you don't eat right away. Rewarm briefly in a bowl of hot water from the faucet when ready to eat some more eggs on later days. If you also have something like cooked brown rice on hand (Uncle Ben's offers one that will cook in ten minutes), eggs will make a nice meal with the addition of some good vegetable(s) and a bit of fruit. Rice is the only grain you're not very likely to have a problem with digesting. (As well as glutens, corn sensitivity is very common, so just figure on skipping all the common grains other than rice. I don't know anything about more exotic things like quinoa. Once you get yourself stabilized, you can always reintroduce corn on an infrequent basis.)

You might buy whatever kinds of chicken happen to be on sale there and boil (simmer) it up in water (or chicken broth with some lemon juice added if you can afford that) on the weekend and have that at various points along with some of the brown rice that you also cooked over the weekend. (Cook your brown rice in the leftover water/broth.) Assuming you have a microwave, that kind of warmup cooking doesn't take very long, though it's not quite so fast as a shake. You might think of yourself as being Chinese? I think the Chinese have been doing something like this for centuries when meats were scarce. In one case, try scrambling up some eggs and leaving some leftover to combine with some meat scraps in a pan with some oil (virgin olive oil if possible) and (ideally) some onions (classically, green onions) to warm up with your rice, all scrambled up together. I have also done this with some finely chopped fresh kale too and it's tasty.

I know you are thinking that I don't have a clue as to what it's like to be trying to operate with your monthly income and your need for quick meals. That's mostly true, but my imagination is pretty good, Moleface. I can also imagine being in your shoes and having to drop out of grad school due to an overwhelming disability. Then where would you be in your progression to a PhD and the possibility of doing the work in your life that you most want to do to support yourself?

I'm not in your shoes and can't know where you might find the increase in a food budget that this would mean now and in the foreseeable future. But even if all you were considering here were the economics of the situation and your life, you'd be better off to spend the extra money on fixing your health now via necessary food avoidance of offenders, even if you have to borrow the extra money that getting enough protein in a healthy diet might require.

Wayne Persky was once in your shoes, and wound up having to drop out of graduate school altogether due to an overwhelming disability. This is no little problem you're dealing with. It's worse for you than it is for me, because most of the time I'm reasonably close to a bathroom here at home. But you can't stay in school forever if you're liable to having accidents when you go somewhere there's no bathroom right by your side. It can become a disability. I've had really bad problems a couple of times away from home, and it's so humiliating I never want to go out. And think ahead to having to deal with this as an oldster, like me: these problems are totally exhausting, to an extent that it's not in the ballpark of your normal use of the word exhausting. I feel as if I'm going to pass out much of the time nowadays when that stuff is going on. And in all my health problem history investigating, inflammation keeps coming up as the historical root of most, if not all, of the issues.

As far as I can tell, inflammation issues wherever they occur in the body generally all starts with the gut and its responses to what you eat. I realize now that not dealing with my problems in my twenties, when my allergist delivered the bad news, meant that my health in innumerable ways has been horrible for a large portion of my life, and becoming more seriously horrible with each year of age. I'd urge you to handle this now, no matter how difficult and unpalatable it is. (I'm currently discovering for myself just how difficult it is.)

The Swanson vitamins could be the issue as well, seeing as the company refuses to officially confirm their products as gluten free. The ingredients show nothing that should be a problem, aside from cellulose - and apparently wheat cellulose doesn't even contain the gluten proteins.


Oh, dear. I'd suggest dropping the Swanson vitamins immediately. Just doing that single thing first might indicate that the problem you know you have for sure--gluten--hasn't been addressed completely. Did you, by any chance, start with the Swanson's around the time your symptoms returned? You can get problems from a product that isn't supposed to retain any proteins from its origins, but often in the practical processes of producing it actually does retain some protein. I know I recently read a homepage of an extreme sufferer of corn allergies who can't use corn oil at all.

I'd suggest dropping the Swanson's no matter what. Through a search on Glucosamine & Chondroitin Sulfate, I bumped into some information on Swanson's that was posted by a veterinarian, Wendy Blount:

http://wendyblount.c...Chondroitin.pdf

Scroll on down the page to the "Not Recommended" products. Swanson is a brand I've always considered and Nature's Plus is one I currently have several supplements from too. Never again on either one for me. Of course, this is just one snapshot of a company's multiple products and the others might be okay. But I figure it's my health I'm risking, and why take a chance?

If you want to replace an anti-oxident Swanson's with another anti-oxidant, NOW Foods makes one that looks exceptionally good to me: "Super Antioxidants." I am currently taking most of these same ingredients in separate pill form, and thinking now how much better it might be to go with this approach on most days.

This problem is made all the more puzzling by the fact that I had absolutely no intestinal issues for about a six month period after the initial hellish month of detoxing from gluten. Then they mysteriously started up again this past autumn and they're now debilitating. First I have constipation, then it turns into repeated severe diarrhea attacks for the first several hours of every single day. It's hard to live a normal life while dealing with problems like this.


Three guesses: 1) The Swanson's antioxidant. Something in there that you probably had no reaction to originally became a problem merely through its overexposure (daily intake). 2) You need to progress to cutting out some more broad categories of foods. 3) You have something new adding to the problem of cooling down your digestive inflammation, like H. Pylori, perhaps, or something like a new yeast problem. If this is happening every single day now, you're in the middle of a crisis. Been there, done that, lots of times. You could use a little sympathy now too, and you have it! I know what this feels like.

The daily intake thing is an important part of the process in becoming allergic to anything. Anything an allergy-prone person exposes herself/himself to on a daily basis hugely increases the chances that the body is going to eventually start to react to it, according to my allergist. (I know this is bad news, but you need as much as possible to take this into consideration. It's a necessary calculation that I personally find very, very difficult to do, and I don't do it well.)

I'm getting a PHD in school, but until then I won't have any disposable income whatsoever. Once I finally graduate and get a decent job, I intend to get a full battery of allergen tests done.


When I had my testing done, our (good) insurance policy paid most of it. But its original billing cost a fortune for those days: roughly $700. I guess you'd likely have to pay several times that now. But didn't you buy student health insurance? Check your policy; it might pay for most of it too. If it did, I'd guess that the doctor involved might let you take quite awhile to pay a little each month toward your fairly small share of the cost.

Regarding your upcoming degree, that's fantastic. One suggestion: it's never too early to begin a job search preliminary investigation. If you see certain specialities cropping up more than the one you're headed toward, see whether you might manage to incorporate some of those specialties in your research, even while remaining in your major focus.

I say that from a close knowledge of the difficulty many PhD's are running into now finding jobs. I helped a postdoc with fabulous credentials hunt out places where full regular positions were being advertised (in case something wasn't appearing in the professional sources where next to nothing was showing up). I went literally to all fifty states (online) to the human resources areas for a huge number of colleges and universities, all the way from Harvard down to Podunk college in Nowhere. This was in a hard science area, where ironically the politicians are encouraging our high schoolers to head. (They merely forgot to make some jobs to send the students to after the degree.) And I assume that NIH is in the process of losing positions now too, thanks to the current budgetary problems. Anyway, a few good offers did eventually appear, but there were so few jobs--next to nothing--to start with as possibilities. The only area I saw with plentiful school openings was psychology, I guess because that major is so popular with undergraduates.

Well that gives you plenty to think about. I hope you're able to see some improvements soon!

Best wishes, Mary
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#58 RJ100

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Posted 14 March 2013 - 01:49 PM

Found this, thought it was interesting...


The promise of N-acetylcysteine in neuropsychiatry



There are several similar studies indicating NAC as a valuable tool for psychiatry. I believe it helped my OCD and excitotoxicity, but in order for me to feel the benefit I had to take 2g per day, and as with most things there may have been a cost.

#59 moleface

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Posted 15 March 2013 - 07:56 PM

Mary,

Thank you so much for your thoughtful, empathetic and detailed response! I really do appreciate someone taking so much time and effort to give me such useful advice. Some additional changes to my lifestyle have been a long time coming, and your post has motivated me to finally go through with them.

I'd suggest giving up dairy totally for the next couple of weeks before trying to move forward with anything else. That might do the trick, or it might take a little bit longer to know whether it's getting better or not. If you decide it's definitely getting better, give it several more weeks and decide whether it's getting better fast enough to figure that your gut is going to eventually completely heal that way.

Almost everyone who has a problem with cow's milk and cow dairy products also has a problem with beef. I'm pretty sure that if you find yourself having a problem with diary proteins, you also need to strictly avoid beef. That would be the next thing to give up if giving up dairy doesn't work sufficiently well (assuming you once in awhile have some beef).

Having lamb when/if you can ever afford it is a good beef alternative. Few people have issues with lamb. Whether that's because of its cost--so you've never had it on a basis close to everyday, thus not increasing the exposures--or maybe because it has no relationship to drinking cow's milk--or something else about its chemistry--I don't know. I just know it's relatively safe for most people with digestive problems. Pork is less likely than beef to bring a problem too, but more so than chicken and turkey are. You might also have a problem with eggs; that's more likely than for pork but less likely than beef. (I'm remembering this from long ago with my testing, where the reporting sheet went down the line in order of the probabilities taken from stats on a large US population. Divided into 3 columns on one sheet, I think I recall that eggs were in the first column and pork was in the second.)


Yeah, I've been considering for awhile that casein or lactose could be issues for me. The only reason I've stuck with that egg whey and soy protein powder is because it's the least expensive concentrated protein powder I've been able to find that's also gluten free. I'm going to see if pure soy protein powder or maybe even dirt-cheap dried soybeans will be an acceptable replacement.

I'll also look into alternative sources of animal protein, though unfortunately I'm not a huge fan of pork. I've been semi-vegan for the last year, more out of necessity than anything else, and I don't mind foregoing meat altogether for the time being as long as I'm getting all my necessary amino acids. I've found that it's a far less economical source of protein compared to beans and rice.

The two most affordable sources of protein, if you can't eat soy or beans, would be eggs or chicken on sale. But as a first step (if simply avoiding dairy and beef doesn't work), try just eliminating the soy only for a couple of weeks; you'd still have beans left as your major source of protein that way. Only if that doesn't work, you'd need next to go on to eliminating all beans.

I have never been a believer in limiting egg consumption because of cholesterol, and I think the more recent research doesn't back up the idea of limiting yourself on eggs either. You could hardboil something like 8 eggs at one time in your largest pan, making sure you don't overdo it (edge of yolk will turn grey if you do that), cool them a bit in water, and refrigerate what you don't eat right away. Rewarm briefly in a bowl of hot water from the faucet when ready to eat some more eggs on later days. If you also have something like cooked brown rice on hand (Uncle Ben's offers one that will cook in ten minutes), eggs will make a nice meal with the addition of some good vegetable(s) and a bit of fruit. Rice is the only grain you're not very likely to have a problem with digesting. (As well as glutens, corn sensitivity is very common, so just figure on skipping all the common grains other than rice. I don't know anything about more exotic things like quinoa. Once you get yourself stabilized, you can always reintroduce corn on an infrequent basis.)


I've definitely considered adding lots of eggs to my diet for awhile. I could stand to eat some richer food anyway - even after the worst of my celiac has subsided, I'm still pretty ridiculously underweight - 6 foot 1 and 140 pounds.

I know you are thinking that I don't have a clue as to what it's like to be trying to operate with your monthly income and your need for quick meals. That's mostly true, but my imagination is pretty good, Moleface. I can also imagine being in your shoes and having to drop out of grad school due to an overwhelming disability. Then where would you be in your progression to a PhD and the possibility of doing the work in your life that you most want to do to support yourself?

I'm not in your shoes and can't know where you might find the increase in a food budget that this would mean now and in the foreseeable future. But even if all you were considering here were the economics of the situation and your life, you'd be better off to spend the extra money on fixing your health now via necessary food avoidance of offenders, even if you have to borrow the extra money that getting enough protein in a healthy diet might require.


Unfortunately I'm temporarily living in a small economically impoverished town where jobs (even last-resort minimum wage positions that entail hard labor or fast food preparation) are extremely scarce. I've been living off $1-2 an hour online surveys for the last couple years, along with student loan money now that I'm in my first year of college. About pursuing a doctorate - I didn't mean to imply that I'm already in graduate school - I'm only in my first year of college. I'm very adamant about getting a PHD in some field of psychology though.

I actually spend about $70 a month on all my supplements, and I'm aware that whole food is preferable to supplemental vitamins - but I've been dealing with a severe inflammatory state caused by my Celiac, and it's yet to completely subside even after a little over a year of being (hopefully) gluten free. Concentrated vitamin C, EGCG, niacinamide etc all made a profound impact on my inflammatory symptoms, so I'm hesitant to give them up. Only about $15-20 of my supplement budget actually goes to vitamins - all the rest is spent on nootropics, tranquilizers and natural antidepressants to treat my PTSD and anxiety disorder. I'd just go to a free psychiatric clinic, but there's only one clinic in my community and they repeatedly accused me of faking my anxiety symptoms when I was briefly seeing a free psychiatrist there in the early 2000s. So for the time being, I have no choice but to put aside a fairly substantial chunk of my budget to buying phenibut, sceletium, St John's Wort, etc to self-treat my symptoms.

Oh, dear. I'd suggest dropping the Swanson vitamins immediately. Just doing that single thing first might indicate that the problem you know you have for sure--gluten--hasn't been addressed completely. Did you, by any chance, start with the Swanson's around the time your symptoms returned? You can get problems from a product that isn't supposed to retain any proteins from its origins, but often in the practical processes of producing it actually does retain some protein. I know I recently read a homepage of an extreme sufferer of corn allergies who can't use corn oil at all.

I'd suggest dropping the Swanson's no matter what. Through a search on Glucosamine & Chondroitin Sulfate, I bumped into some information on Swanson's that was posted by a veterinarian, Wendy Blount:

http://wendyblount.c...Chondroitin.pdf

Scroll on down the page to the "Not Recommended" products. Swanson is a brand I've always considered and Nature's Plus is one I currently have several supplements from too. Never again on either one for me. Of course, this is just one snapshot of a company's multiple products and the others might be okay. But I figure it's my health I'm risking, and why take a chance?

If you want to replace an anti-oxident Swanson's with another anti-oxidant, NOW Foods makes one that looks exceptionally good to me: "Super Antioxidants." I am currently taking most of these same ingredients in separate pill form, and thinking now how much better it might be to go with this approach on most days.


This is definitely something I need to do and it's been a long time coming. I've been in denial about it, since I was taking these same Swanson supplements during the half year or so where I had a nearly-complete remission of my celiac symptoms - but from what I understand, they source the powder in their gelcaps from multiple overseas sources, and there's no telling if one particular batch happens to contain wheat derived ingredients. That could explain why I didn't have a reaction to Swanson products before, but now suddenly I'm having severe intestinal issues that are seemingly unexplainable.

I'm going to probably switch over to bulk powder versions of everything I take, which would be comparably priced to Swanson's pre-capped products. That's the only reason I've stuck with Swanson in the first place - their supplements are so ridiculously inexpensive compared to everyone else, and I love being able to afford a wide array of vitamins on such a limited budget.

Well that gives you plenty to think about. I hope you're able to see some improvements soon!

Best wishes, Mary


It certainly did! Thanks again for the genuine concern and great advice. You've inspired me to make some additional serious changes to my diet. Recreating the toilet scene from Trainspotting in public restrooms every day is no way for a person to live.

Thanks again!

-Steve

Edited by moleface, 15 March 2013 - 08:07 PM.


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#60 guitarparty

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Posted 17 March 2013 - 12:05 AM

Thank you so much for your thoughtful, empathetic and detailed response! I really do appreciate someone taking so much time and effort to give me such useful advice. Some additional changes to my lifestyle have been a long time coming, and your post has motivated me to finally go through with them.


You're very welcome. Changing a losing game... a really good idea!

I'll also look into alternative sources of animal protein, [...]I've been semi-vegan for the last year


It took awhile for it to really sink in for me that you're low on animal sources of protein. The probability is high that you're low on vitamin B12, and maybe alarmingly low, unless you're already on a good B12 supplementation regimen. As your very first priority, you need to take a B-Complex tablet daily, and make it one whose B12 is at least partly in the form of menthylcobalamin, not cyancobalamin, and ideally with some of the B9 in the folate form, not just folic acid. As long as you take that B-Comlex vitamin, vegan will be fine *if* your gut issues are solved and *if* you have no intrinsic factor problems to be able to absorb the B12. But to be certain about the potential absorbability issue, I'd suggest taking a B12 sublingual losenge daily at the same time with the B-Complex vitamin (those things work together, especially the B9 with B12). The reason for the losange form is that even if your intestinal absorption is terrible, if you suck on a large dosage losange of B12 in its more absorbable form (methycobabamin), then you can absorb a fraction of it via your saliva before it washes down to your gut. Also consider that if you're very deficient now, you need a huge dose to try to catch up. I take the Jarrows "B-Right" B-complex formula and a 5,000 mg. Jarrows Methyl B-12 losange daily. Whatever B12 vitamin you choose, it needs to be in the more expensive and less common form of methylcobalamin.

http://b12awareness....ould-it-be-b12/

http://www.health-bo...ingernails.html

I'm still pretty ridiculously underweight - 6 foot 1 and 140 pounds.


Think up healthy stuff to eat that's also fattening when eaten in a high-carb diet. Avacados, nuts, seeds, virgin olive oil, virgin coconut oil. I've nothing bad to say about supplements at all, but in the relative hierarchy of what's important to your health, I just think that a good healthy diet comes first before you do anything else.

Unfortunately I'm temporarily living in a small economically impoverished town where jobs (even last-resort minimum wage positions that entail hard labor or fast food preparation) are extremely scarce. I've been living off $1-2 an hour online surveys for the last couple years, along with student loan money


Think long term here. This is a losing strategy for your life. You have this chance in your life now that will never be as good as it is today. Don't spend your time sitting in front of a computer for piddly amounts of money. Set a reasonable limit on non-class related computer use, and get out and about campus looking for work, volunteering for activities, and making connections. If you want to go to graduate school, you're not likely to be accepted without some *strong* recommendations from some professors who know you quite well because of activities x,y, and z that they're involved with too.

There's an office on campus that handles students who'd like to work places on campus like the dining hall, library, etc. Also there are professors who do research that might have some money to pay someone to clean out their rat cages, etc. You ought to show up in person at all those professor's doors and ask for work, explaining that you're a fast learner and willing to work hard. Assuming they have nothing available, hand each one a one-sheet contact info/explanation/resume selling yourself for campus work as a professor's aide for whatever needs doing and request that they keep you in mind if anything should change.

About pursuing a doctorate - I didn't mean to imply that I'm already in graduate school - I'm only in my first year of college. I'm very adamant about getting a PHD in some field of psychology though.


You might change your mind about what you want to major in several times and you also might decide that getting into graduate school isn't extra helpful in doing what you'd like to do in life; this is a little early to make a firm decision. Assuming good social skills, just having a college degree will put you somewhere near the top in consideration for promotion if you start out at the bottom somewhere in the personnel department (of Walmart or government employment maybe), for example. It doesn't hurt to survey the chances of employment now with any one particular major if you do or do not successfully enter graduate school, but there are jobs around that don't require any one particular major, particularly if you are willing to start at the bottom.

If you are pretty good at math and actually enjoy it, a potential major or minor to consider would be in the math, statistics, or computer science areas. Assuming you don't necessarily find employment or a graduate school pathway through the major or minor directly, it looks wonderful on a resume; it's a way for a potential employer to assume that you're smart. If you're trying to get into graduate school in any other area (like psychology) potential future professors evaluating your application would also think you more of a standout with a hefty successful math component to your education. A near-4.0 grade average counts big time too, of course.

Regarding psychology, make sure you don't base that choice on my previous remarks. Yes, there are (relatively) plenty of college teaching jobs available in psychology, but you must also take into account that from among the huge numbers of undergraduate college psychology majors, many will be applying to grad school, and though many will wind up with a Master's degree, that still leaves a good many with PhD's looking to fill those multiple slots that I saw while searching in another PhD job area. One other thing to think about: really, really analyze yourself deeply and see how you feel about research. You can get a master's degree without being good at research ideas, but there are far too many people with master's degrees in psychology/most fields than there are potential jobs available. There are plenty of unemployed psychology masters folks around who can't find work at all. (The gas filling station manager won't hire you because you're overqualified for that and he knows you won't be happy there.)

A PhD is always a research degree, in whatever field you go into. In psychology, I think you'd either want to find any work you could get with a simple psychology undergraduate degree (expecting to move up fast because of your college degree generally) or plan to get the PhD because you're good at and like to do research and might be more likely to find employment through that route.

I actually spend about $70 a month on all my supplements, and I'm aware that whole food is preferable to supplemental vitamins - but I've been dealing with a severe inflammatory state caused by my Celiac, and it's yet to completely subside even after a little over a year of being (hopefully) gluten free. Concentrated vitamin C, EGCG, niacinamide etc all made a profound impact on my inflammatory symptoms, so I'm hesitant to give them up. Only about $15-20 of my supplement budget actually goes to vitamins - all the rest is spent on nootropics, tranquilizers and natural antidepressants to treat my PTSD and anxiety disorder. I'd just go to a free psychiatric clinic, but there's only one clinic in my community and they repeatedly accused me of faking my anxiety symptoms when I was briefly seeing a free psychiatrist there in the early 2000s. So for the time being, I have no choice but to put aside a fairly substantial chunk of my budget to buying phenibut, sceletium, St John's Wort, etc to self-treat my symptoms.


I'm redoing my picture of you now, and guessing your age is older than a typical college undergrad.

Avoid telling about your intensely personal mental problems on the internet; that could come back to haunt you just as you're ready to step into the chairmanship of General Electric, or Secretary of State, or even your typical employer. *Nothing on the internet is private.*

Simply starting with a B-Complex and B12 sublingual now might be the answer to your prayers in the mental health area. I mean possibly THE answer, totally. If you need B12, nothing else you do is going to matter to your mental health or your health generally.

I'd suggest two things, regardless of your age: 1) start the B vitamins now, and 2) go home for a visit at your first opportunity and talk frankly about your situation to your parent(s). You can use the moral support, and they really do want to know what's happening with you and care about you. Depending on their own financial circumstances, perhaps they might even be able to contribute something to helping you toward a diet that's less problematic for someone with your verified digestive problems.

All colleges that I know anything about have counselors available for free to all students, headed up by a PhD clinical psychologist. Go there after you've gotten started on your B-Vitamin supplements.

See whether you can't get on the waiting list to work in the college dining hall there. That kind of job can save a ton on your eating expenses.

NAC might help, especially if you have any OCD or depression issues. I don't think PTSD is an easy one, but 7-Keto DHEA at a dose of 50 to 100 mg might help some, as well as yoga. (If you have bipolar problems, don't jump into 7-Keto DHEA; watch for mania and start with a lower dose or don't try it at all.) Start slowly with Yoga by getting good at using Ujjayi breathing first:

http://www.yogajournal.com/poses/2485

The reason for this breathing thing has something to do with retraining the autonomic nervous system.

Last thought... You might need to take some of my advice within a framework of "the goal" instead of something you can immediately turn around and do. It's hard to run around anywhere on campus with serious potty considerations at the forefront; you're lucky right now if you can make it to class and sit there the entire time without potty issues intervening. So put healing your gut at the top of the list first, right next to taking the B Vitamins.

Best wishes for good health and a happy life, Mary





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