7 replies to this topic

[Chupo]

I've recently found out that I'm triple heterozygous for mutations in MTFR genes: C677T, 03 P39P, and A1298C. I have trouble converting folate to the active methylfolate and converting homocystein to methionine. It apparently lowers glutathione levels as well . I know that I should obviously supplement with L-methylfolate but am looking for any further advice on what to do. Would methyl blue help? NAC?

I'm also homozygous for defective genes on SOD2 A16V, which means I'm not good at producing superoxide dismutase. I take C-60oo. Any further advice?

I haven't had any symptoms of oxidative stress that I'm aware of but I do have a family history of cleft lips and palates, autism, and I started getting grey hair in my mid-twenties. Both my maternal granparents died young. One of cancer, the other of alcoholism.

This is very depressing news. Any advice or experience will be greatly appreciated!

[Kevnzworld]

I would take silymarin if and when you either drink alcohol, take Tylenol or pharmaceutical drugs to protect against glutathione depletion.
http://www.researchg...lybium_marianum)_derivative_on_ethanol-induced_oxidative_stress_in_liver/file/42759e0872c4a561d2c90770fe3d3523.pdf
You could also take NAC, as you suggested, and selenium/ selenomethionine, zinc
http://jn.nutrition....3/5/1448S.short
http://europepmc.org...ct/MED/11849622
If you are concerned about SOD, you could supplement with Glisodin.
http://www.renerheal...ep deal web.pdf
Others might disagree, but I would take higher doses of a good form of vitamin C, a buffered ascorbate formula given your concern with oxidative stress.

Edited by Kevnzworld, 25 March 2013 - 03:39 PM.

[niner]

This is very depressing news.

Well, look at it this way: Now that you know your status, you can take active steps to alleviate the problem. I can't think of anything better than C60-oo, as it is very likely acting to replace the mitochondrial SOD that you have a problem with. You might want to back that up with a little NAC. We've seen a couple reports that it is synergystic with c60-oo, and if you have glutathione issues, it should help that. I'm not sure Glisodin would be helpful, in that your problem is with mitochondrial SOD, and I think Glisodin is a plant SOD so it wouldn't likely have a mammalian mitochondrial targeting sequence. I don't think methylene blue would be particularly helpful, but between methylfolate, c60-oo, and NAC, you should be good to go. You should probably talk to your family members who may have the same genetics, and let them know about the risks and treatment options. I think you have the ability to not just be normal, but be better than normal, so don't be depressed.

[Chupo]

Thank you, gentlemen. I went and picked up a few more supplements based on your recommendations.

Niner, you're right. I'm probably better off on these supplements, especially C60-oo, with my bad genes than I would be without the supplements with good genes. I have alerted my family members about this and suggested they get their genes tested in case they have mutations that I don't.

I have read anecdotes of improved mood after a few weeks of methylfolate supplementation even when people didn't consider themselves depressed to begin with. It's something to look forward to. We'll see what happens.

[stephen_b]

Here's a (IMO) well researched posting on folate from the Evolutionary Psychiatry blog: Folate! The Beginning.

Edited by stephen_b, 27 March 2013 - 03:53 PM.

[blueocean]

Sorry to bump an old thread, but I too just found out that I have a mutation in the same 3 Genes (C677T, A1298C, P39P) which makes me Triple Heterozygous as well. I also have a mutation in MTHFR A1572G which is one I don't hear discussed much. I haven't started taking any supplements although I did do a month of liposomal glutathione and liposomal vitamin C for other reasons this past summer and felt pretty good while doing it.

I don't do well with Toxins at all. One glass of wine will put me out of commission for a day or two. Other than that I'm pretty healthy other than some depression, low energy, and what I would describe as low seratonin (I can feel it).

Where do you guys think I should start with supplementation?

[Chupo]

Blueocean, I haven't noticed anything different with the addition of the supplements but that doesn't mean they aren't doing their thing. If I were you, I'd go ahead with the supplements recommended above. You might want to look into C60-olive oil as well. It's experimental but one thing people report is better alcohol tolerance among others.

I've searched my 23andme and Promethease reports and cannot find MTHFR A1572G. I suppose it wasn't tested. I don't believe I'd heard of that one before.

[BieraK]

Could methylene blue worsens undermethylation? or on the contrary could this substance produce excess methyl groups?