2 replies to this topic

[malbecman]

Nice summary paper about various studies of resveratrol in humans and some of the contradictory findings, different dose-responses, etc.

http://diabetes.diab.../62/4/1022.long


Exploring the Promise of Resveratrol: Where Do We Go From Here?

• Jill P. Crandall⇑ and
• Nir Barzilai

+Author Affiliations

• 1). However, despite the widespread use of resveratrol as a nutritional supplement and the many health claims made on its behalf, data from human studies are extremely limited. Here, we explore why, in contrast to many studies in mammalian models, the article by Poulsen et al. (2) in this issue ofDiabetes reports that chronic high doses of resveratrol have no demonstrable metabolic effects.
  

[malbecman]

Resveratrol (3,5,4’-trihydroxystilbene), a plant-derived polyphenol and activator of the mammalian sirtuin, SIRT1, has demonstrated promising effects on glucose metabolism in rodent models (1). However, despite the widespread use of resveratrol as a nutritional supplement and the many health claims made on its behalf, data from human studies are extremely limited. Here, we explore why, in contrast to many studies in mammalian models, the article by Poulsen et al. (2) in this issue ofDiabetes reports that chronic high doses of resveratrol have no demonstrable metabolic effects.


Here is another copy of the 1st paragraph...

The main image from the paper.

Edited by malbecman, 25 March 2013 - 05:49 PM.

[niner]

Nice brief paper that is worth a read. The message I took away was that resveratrol may be worth a try if you have a metabolic defect (e.g., insulin resistance) but doesn't do much in that department if you're not very sick. They didn't address anti-inflammatory activity or the benefits of mitochondrial biogenesis- it's mainly coming from a diabetes perspective.