4019 replies to this topic

[Lsdium]

 

 

Intranasal insulin, what a great thing! Major increase in mental stamina and clearheadedness.

 

Thank you, lostfalco!

 

 

Where did you buy it, lourdaud ?

 

The most affordable place in the U.S. by far is Walmart. Novolin R is $24.88. 

 

I've written about its benefits, where to buy it, and how to make it legally at home here. http://www.lostfalco...anasal-insulin/

 

Do you live in the US, Lsdium?

 

 

 

Nope, Europe.

 

Hard to get hold on insulin here. :(

[lostfalco]

Nope, Europe.

 

Hard to get hold on insulin here. :(

 

Got it. Yeah, sorry about that. 

 

Not sure if these are legit sources or if they ship to Europe but a user on healthrising compiled this list. The Benefits of Intranasal Insulin

 

http://www.roidsseek...r</b>-4199.html

http://www.roidsseek...n-nph-8178.html

http://www.neomeds.c...r</b>-3801.html
http://www.neomeds.c...-3-ml-6065.html
http://www.neomeds.c...40-iu-5145.html

https://www.anabol-s...umalog-insulin/
https://www.anabol-s...</b>-eli-lilly/

http://alvgear.com/humulin-r
http://steelgear.net...nsuline-steroid
http://www.originals...n-r</b>-26.html
http://roidspot.net/...&product_id=115

http://onlineshoppha...&product_id=107
https://www.buckaday...cy.com/Novolog/
https://www.buckaday...cy.com/Humalog/

http://www.buypharma...ion-p-2486.html
http://www.buypharma...dge-p-1019.html
http://www.buypharma...ion-p-2470.html

[magta39]

I am running low on tadalafil drops, superior peptides seems to have disappeared, has anyone had experience with blue sky peptides? Or perhaps another supplier they can recommend?  thanks!

[lostfalco]

I am running low on tadalafil drops, superior peptides seems to have disappeared, has anyone had experience with blue sky peptides? Or perhaps another supplier they can recommend?  thanks!

Hey magta, I'm using Blue Sky now that Superior is gone. Hard to know for sure, but Blue Sky's tadalafil seems legit ime. http://www.blueskype...ml-x-30-ml.html

Edited by lostfalco, 21 December 2016 - 04:13 AM.

[lostfalco]

Lostfalco, I thank you for all your effort. It is probably a tiny number who clutter your thread with thank you comments compared to the many more who are grateful. (Why clutter your thread.) I have a comment now, so dual purpose.

 

 I wonder if the strategy of higher treatment times causing more effect followed a few hours by my supplements might be effective. Higher activation of the brain, but for less time perhaps as the supplements might lower it.

 

I have Intranasal Insulin as my next addition, but only after several more weeks at a minimum. I look forward to you writing the ebook/blog post sharing all the research you have about the various therapies. (I noticed your plan when I read your page concerning another members T.B.I. questions. It was helpful.)

 

http://www.lostfalco...in-enhancement/

 

 

http://www.lostfalco...n-injury-etc/ 

No problem, Heisok. I appreciate your kind words. I'm glad you've benefitted from some of my craziness. =)

 

It's definitely worth trying multiple experiments with LLLT/supplements to see if you notice a difference. From a theoretical perspective, the supplements are unlikely to limit the effects of LLLT very much unless you take them such that they enter the brain right around the same time you are lasering. The brief increase in ROS from LLLT is pretty short lived and is only needed for a brief time in order to activate a longer term genetic response (111 genes are affected by LLLT). A few hours later, as you mentioned, should be just fine. I hope your new experiment works well for you! 

Edited by lostfalco, 21 December 2016 - 05:04 AM.

[lostfalco]

Very interesting study using a cryopreserved brain that indicates that phosphodiesterase-5 and -9 inhibitors might have a future as a treatment for Alzheimer's disease. 

 

As you guys know, I'm a big fan of PDE5i (sildenafil, tadalafil, and vardenafil). 

 

As previously mentioned, I'm currently getting my tadalafil from Blue Sky since Superior Peptide recently disappeared. http://www.blueskype...ml-x-30-ml.html

 

"Testing a panel of modulators of cAMP and cGMP signaling pathways, FASS-LTP identified vardenafil and Bay-73-6691 (phosphodiesterase-5 and -9 inhibitors, respectively) as potent enhancers of LTP in synaptosomes from AD cases."

 

https://www.ncbi.nlm...pubmed/27986924

 

J Neurosci. 2016 Dec 16. pii: 2774-16. [Epub ahead of print]

Pharmacological rescue of long-term potentiation in Alzheimer diseased synapses.

Prieto GA1, Trieu BH2, Dang CT3, Bilousova T4, Gylys KH4, Berchtold NC3, Lynch G2, Cotman CW3.

Author information

Abstract

Long-term potentiation (LTP) is an activity-dependent and persistent increase in synaptic transmission. Currently available techniques to measure LTP are time-intensive and require highly specialized expertise and equipment, and thus are not well-suited for screening of multiple candidate treatments even in animal models. To expand and facilitate the analysis of LTP, here we use a flow cytometry-based method to track chemically-induced LTP by detecting surface AMPA receptors in isolated synaptosomes (Fluorescence Analysis of Single-Synapse Long-Term Potentiation, FASS-LTP). First, we demonstrate that FASS-LTP is simple, sensitive, and models electrically-induced LTP recorded in intact circuitries. Second, we conducted FASS-LTP analysis in two well characterized Alzheimer's disease (AD) mouse models (3xTg and Tg2576) and, importantly, in cryopreserved human AD brain samples. By profiling hundreds of synaptosomes, our data provide the first direct evidence to support the idea that synapses from AD brain are intrinsically defective in LTP. Third, we used FASS-LTP for drug evaluation in human synaptosomes. Testing a panel of modulators of cAMP and cGMP signaling pathways, FASS-LTP identified vardenafil and Bay-73-6691 (phosphodiesterase-5 and -9 inhibitors, respectively) as potent enhancers of LTP in synaptosomes from AD cases. These results indicate that our approach could provide the basis for protocols to study LTP in both healthy and diseased human brains, a previously unattainable goal.

SIGNIFICANCE STATEMENT: 

Learning and memory depends on the ability of synapses to strengthen in response to activity. Long-term potentiation (LTP) is a rapid and persistent increase in synaptic transmission which is thought to be affected in Alzheimer's disease (AD). However, direct evidence of LTP deficits in human AD brain has been elusive, primarily due to methodological limitations. Here, we analyze LTP in isolated synapses from AD brain using a novel approach which allows testing LTP in cryopreserved brain. Our analysis of hundreds of synapses supports the idea that AD-diseased synapses are intrinsically defective in LTP. Further we identified pharmacological agents that rescue LTP in AD, thus opening up a new avenue for drug screening and evaluation of strategies for alleviating memory impairments.

 

Edited by lostfalco, 21 December 2016 - 05:20 AM.

[lourdaud]

 

 

 

Intranasal insulin, what a great thing! Major increase in mental stamina and clearheadedness.

 

Thank you, lostfalco!

 

 

Where did you buy it, lourdaud ?

 

The most affordable place in the U.S. by far is Walmart. Novolin R is $24.88. 

 

I've written about its benefits, where to buy it, and how to make it legally at home here. http://www.lostfalco...anasal-insulin/

 

Do you live in the US, Lsdium?

 

 

 

Nope, Europe.

 

Hard to get hold on insulin here. :(

 

 

I bought mine from roidssek, this product http://www.roidsseek...lin-r-4199.html

[lostfalco]

Hey, what's up my friends?

 

Just wanted to give you guys a quick heads up that irc.bio has responded to our many requests and are now carrying ibudilast! https://irc.bio/prod...ilast-solution/

 

Pinatos seems to be discontinued so this is now our most affordable source. I just received my first order in the mail so I can't vouch for it yet but I just wanted to let everyone know since it's helped a lot of people with inflammation issues. 

 

For those of you who aren't familiar with how it works (I know most of you are at this point) here's a little info on its mechanisms of action. http://www.lostfalco...n-fog-two-step/

Edited by lostfalco, 22 December 2016 - 08:27 PM.

[magta39]

Hey, what's up my friends?

 

Just wanted to give you guys a quick heads up that irc.bio has responded to our many requests and are now carrying ibudilast! https://irc.bio/prod...ilast-solution/

 

Pinatos seems to be discontinued so this is now our most affordable source. I just received my first order in the mail so I can't vouch for it yet but I just wanted to let everyone know since it's helped a lot of people with inflammation issues. 

 

For those of you who aren't familiar with how it works (I know most of you are at this point) here's a little info on its mechanisms of action. http://www.lostfalco...n-fog-two-step/

Thanks!  What is a good dose to start with...how many drops per day?

[lostfalco]

Thanks!  What is a good dose to start with...how many drops per day?

 

 

 

No problem, magta. I would start with 10mg per day and if that works well for you then no need to go higher. I usually take 10mg, twice per day (once upon waking and once halfway through the day). 

Edited by lostfalco, 23 December 2016 - 03:19 PM.

[magta39]

 

Hey, what's up my friends?

 

Just wanted to give you guys a quick heads up that irc.bio has responded to our many requests and are now carrying ibudilast! https://irc.bio/prod...ilast-solution/

 

Pinatos seems to be discontinued so this is now our most affordable source. I just received my first order in the mail so I can't vouch for it yet but I just wanted to let everyone know since it's helped a lot of people with inflammation issues. 

 

For those of you who aren't familiar with how it works (I know most of you are at this point) here's a little info on its mechanisms of action. http://www.lostfalco...n-fog-two-step/

Thanks!  What is a good dose to start with...how many drops per day?

 

I noticed they also have ibudilast powder 1000mg for 65 dollars.

[lostfalco]

I noticed they also have ibudilast powder 1000mg for 65 dollars.

 

Exactly! Sorry, forgot to mention that. Here's the link. https://irc.bio/prod...udilast-powder/

[lostfalco]

Hamblin is back with another review article!

 

Main points:

1. 10Hz pulsing is the best. "The first studied pulsed against continuous laser irradiation, finding that 10 Hz pulsed was the best."

2. 660nm and 810nm are effective. "The second compared four different wavelengths, discovering only 660 and 810 nm to have any effectiveness, whereas 732 and 980 nm did not."

3. "The third looked at varying regimens of daily laser treatments (1, 3, and 14 days) and found that 14 laser applications was excessive."

 

https://www.ncbi.nlm...pubmed/28001759

 

Photomed Laser Surg. 2016 Dec;34(12):587-598. doi: 10.1089/pho.2015.4051.

Transcranial Low-Level Laser (Light) Therapy for Brain Injury.

Thunshelle C1,2, Hamblin MR2,3,4.

Author information

Abstract

BACKGROUND: 

Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI).

METHODS: 

We review the fundamental mechanisms at the cellular and molecular level and the effects on the brain are discussed. There are several contributing processes that have been proposed to lead to the beneficial effects of PBM in treating TBI such as stimulation of neurogenesis, a decrease in inflammation, and neuroprotection. Both animal and clinical trials for ischemic stroke are outlined. A number of articles have shown how transcranial LLLT (tLLLT) is effective at increasing memory, learning, and the overall neurological performance in rodent models with TBI.

RESULTS: 

Our laboratory has conducted three different studies on the effects of tLLLT on mice with TBI. The first studied pulsed against continuous laser irradiation, finding that 10 Hz pulsed was the best. The second compared four different wavelengths, discovering only 660 and 810 nm to have any effectiveness, whereas 732 and 980 nm did not. The third looked at varying regimens of daily laser treatments (1, 3, and 14 days) and found that 14 laser applications was excessive. We also review several studies of the effects of tLLLT on neuroprogenitor cells, brain-derived neurotrophic factor and synaptogenesis, immediate early response knockout mice, and tLLLT in combination therapy with metabolic inhibitors.

CONCLUSIONS: 

Finally, some clinical studies in TBI patients are covered.

 

[Heisok]

It looks like Margaret A. Naeser, PhD et al have some more ongoing studies LED work. Too steep of a price for me  to read the article.

 

"Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury"

 

Objective: We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is released from the cells increasing regional blood flow in the brain. Review of published studies: In our previously published study, 11 chronic TBI patients with closed-head TBI caused by different accidents (motor vehicle accident, sports-related, improvised explosive device blast injury) and exhibiting long-lasting cognitive dysfunction received 18 outpatient treatments (Monday, Wednesday, Friday for 6 weeks) starting at 10 months to 8 years post-TBI. LED therapy is nonthermal, painless, and noninvasive. An LED-based device classified as nonsignificant risk (FDA cleared) was used. Each LED cluster head (5.35 cm diameter, 500 mW, 22.2 mW/cm²) was applied for 9 min 45 sec (13 J/cm²) using 11 locations on the scalp: midline from front-to-back hairline and bilaterally on frontal, parietal, and temporal areas. Testing was performed before and after transcranial LED (tLED; at 1 week, 1 month, and at 2 months after the 18th treatment) and showed significant improvements in executive function and verbal memory. There were also fewer post-traumatic stress disorder (PTSD) symptoms reported

 

"Ongoing studies: Ongoing, current studies involve TBI patients who have been treated with tLED using either 26 J/cm² per LED location on the head or treated with intranasal only (iLED) using red (633 nm) and NIR (810 nm) diodes placed into the nostrils. The NIR iLED is hypothesized to deliver photons to the hippocampus, and the red 633 nm iLED is believed to increase melatonin. Results have been similar to the previously published tLED study. Actigraphy sleep data showed increased time asleep (on average one additional hour per night) after the 18th tLED or iLED treatment. LED treatments may be performed in the home. Sham-controlled studies with veterans who have cognitive dysfunction from Gulf War Illness, blast TBI, and TBI/PTSD are currently ongoing."

 

http://online.lieber...9/pho.2015.4037

[lourdaud]

My dad is starting to show mild symptoms of dementia.
What would you recommend, lostfalco, for trying to reverse his cognitive decline?

[magta39]

On a similar note Lostfalco, what kind of starting protocol would someone use for LLLT if they suffered a traumatic brain injury a year ago?  Is daily LLLT best? Concentrating on the injured brain area or whole head?  Forgive me but sometimes the scientific papers are a bit difficult to interpret.  Many thanks!

Edited by magta39, 23 December 2016 - 07:58 PM.

[DareDevil]

DISCLAIMER

 

I don't recommend using a saline bottle to make an insulin nasal spray.

This was a workaround due to not finding a store with an empty bottle.

Edited by DareDevil, 24 December 2016 - 05:01 AM.

[DareDevil]

I'm on a roadtrip and unable to get nasal spray bottles shipped to me so I bought a bottle of Novolin R at Walmart and a $2 bottle of nasal saline solution. I emptied the saline solution and without rinsing I used an insulin syringe to remove the contents of the vial of Novolin R which I then injected into the tiny nozzle of the emptied saline spray bottle. I had to repeat this 20 times to transfer the 10ml of insulin with a 0.5ml syringe. Once done it doesn't look like the residual salt - yes it is very salty - stops the insulin from being effective. I can't dose it well, so I started with a spray in each nostril, which after about an hour I repeated, likewise 4 times. So that's a total of 8 sprays in half a day. I find that it has an effect. I notice much more detail in my vision, a heightened visual awareness. Otherwise I can't notice anything different in my faculties. I'm not undergoing any neurological problems, this might be why. I am testing it out on myself before suggesting it to my grandmother who is in the early stages of dementia. I won't have her doing anything I haven't validated first. FWIW.

 

DareDevil

 

 IMG_20161223_094504309.jpg   135.92KB   4 downloads

[DareDevil]

I wish to thank Lost Falco for bringing this to my attention. It is a GO for granny.

Today, day two, I used horizontal squirts with carried more of a load than the vertical spray.

Verdict = EFFECTIVE

 

My test is simple, aside from the subjective impression of greater clarity I also remarked:

 

While driving at speed I usually can only decipher half of the strip mall signs.

Today I am able to not only cleary read and mentally register all of them but,

I also manage to scan and read all the store signs in the strip malls.

 

This means that it has activated my mental perception including depth.

Driving in dense Florida traffic I'm able to cast my gaze several intersections ahead.

 

Unless there are side effects my grandmother will be on this soon.

I bet she'll even be able to get her driver's licence back.

 

Cheers,

DareDevil

PS. I didn't mean to derail this thread. Back on topic.

 

[lostfalco]

My dad is starting to show mild symptoms of dementia.
What would you recommend, lostfalco, for trying to reverse his cognitive decline?

Hey lourdaud, I'm really sorry to hear about your father. The #1 thing I would recommend is Dr. Bredesen's protocol. I'll track down and post the actual studies in the next day or two, but the Silicon Valley Health Institute just posted an excellent talk he gave recently. Check it out below to get started and I'll get back to you soon with the studies. =)

 

Edited by lostfalco, 25 December 2016 - 06:25 AM.

[lostfalco]

My dad is starting to show mild symptoms of dementia.
What would you recommend, lostfalco, for trying to reverse his cognitive decline?

Hey man, sorry about the delay. Here are the two main studies regarding Dr. Bredesen's protocol. Of course, they are just case studies (in a handful of people) but I really like the comprehensive, multifaceted approach and the results have been pretty amazing. 

 

https://www.ncbi.nlm...les/PMC4931830/

https://www.ncbi.nlm...les/PMC4221920/

 

Here's a chart that summarizes the program. 

http://www.longecity...-1466095451.png

[lostfalco]

On a similar note Lostfalco, what kind of starting protocol would someone use for LLLT if they suffered a traumatic brain injury a year ago?  Is daily LLLT best? Concentrating on the injured brain area or whole head?  Forgive me but sometimes the scientific papers are a bit difficult to interpret.  Many thanks!

Hey magta, here are the two main studies that utilized LEDs to treat traumatic brain injury.

https://www.ncbi.nlm...les/PMC3104287/

https://www.ncbi.nlm...les/PMC4043367/

 

I've written an article about how to exactly imitate their dosing using the affordable LEDs here. 

http://www.lostfalco...therapy-dosing/

[lostfalco]

I wish to thank Lost Falco for bringing this to my attention. It is a GO for granny.

Today, day two, I used horizontal squirts with carried more of a load than the vertical spray.

Verdict = EFFECTIVE

 

My test is simple, aside from the subjective impression of greater clarity I also remarked:

 

While driving at speed I usually can only decipher half of the strip mall signs.

Today I am able to not only cleary read and mentally register all of them but,

I also manage to scan and read all the store signs in the strip malls.

 

This means that it has activated my mental perception including depth.

Driving in dense Florida traffic I'm able to cast my gaze several intersections ahead.

 

Unless there are side effects my grandmother will be on this soon.

I bet she'll even be able to get her driver's licence back.

 

Cheers,

DareDevil

PS. I didn't mean to derail this thread. Back on topic.

Very cool, DareDevil! You're not derailing the thread at all. How have things been going with your grandmother the past week or so?

[mkmossop]

I have a question about insulin. I started a few days ago, one squirt per day (did one day with two squirts). So far can't say I've noticed much of anything.

 

I'm wondering how exactly we're supposed to spray it though. I was worried at first of putting it too far up my nose because I didn't want it to run into my mouth and end up ingesting it and having it affect my systemic insulin. I read a bit about oral insulin however and it seems like insulin gets broken down in the stomach and therefore wouldn't have an effect on systemic levels.

 

So how exactly are we supposed to spray this stuff. Do you stick it way upyour nose, or just a little and spray it in the nostrils? That's what I've been doing, but I'm thinking further up the nose may be more effective? After you spray it should you snort it to help absorb it? Would appreciate any advice!

 

Also DareDevil, was your consensus of "very effective" using 8 sprays per day as described in your first post, or was it less?

[resveratrol_guy]

Hey lourdaud, I'm really sorry to hear about your father. The #1 thing I would recommend is Dr. Bredesen's protocol. I'll track down and post the actual studies in the next day or two, but the Silicon Valley Health Institute just posted an excellent talk he gave recently. Check it out below to get started and I'll get back to you soon with the studies. =)

 

 

I just saw this...

 

Most of us are familiar with the "36 interventions" to thwart Alzheimer's, but this video is an update on that. It's well worth the hour of time. Frankly, it's the most useful video I've seen in a year. Spoiler: The most incredible part is that one patient went from 17th to 75th percentile in hippocampal volume! It was confirmed by 2 different radiologists with different skill sets, only because the first radiologist said it must have been a mistake in his interpretation because it couldn't happen.

 

Here's Bredesen's website: http://mpi-cognition.com  They're in the process of training doctors to replicate the program.

Edited by resveratrol_guy, 02 January 2017 - 07:25 AM.

[lostfalco]

I just saw this...

 

Most of us are familiar with the "36 interventions" to thwart Alzheimer's, but this video is an update on that. It's well worth the hour of time. Frankly, it's the most useful video I've seen in a year. Spoiler: The most incredible part is that one patient went from 17th to 75th percentile in hippocampal volume! It was confirmed by 2 different radiologists with different skill sets, only because the first radiologist said it must have been a mistake in his interpretation because it couldn't happen.

 

Here's Bredesen's website: http://mpi-cognition.com  They're in the process of training doctors to replicate the program.

 

I know! Isn't this amazing stuff? Really looking forward to his book in May. 

[lostfalco]

I have a question about insulin. I started a few days ago, one squirt per day (did one day with two squirts). So far can't say I've noticed much of anything.

 

I'm wondering how exactly we're supposed to spray it though. I was worried at first of putting it too far up my nose because I didn't want it to run into my mouth and end up ingesting it and having it affect my systemic insulin. I read a bit about oral insulin however and it seems like insulin gets broken down in the stomach and therefore wouldn't have an effect on systemic levels.

 

So how exactly are we supposed to spray this stuff. Do you stick it way upyour nose, or just a little and spray it in the nostrils? That's what I've been doing, but I'm thinking further up the nose may be more effective? After you spray it should you snort it to help absorb it? Would appreciate any advice!

 

Also DareDevil, was your consensus of "very effective" using 8 sprays per day as described in your first post, or was it less?

Hey mkmossop, I've added a video below that explains how to use a nasal spray. Everything he says is good for INI except for the shaking part. You want to aim it slightly away from the septum, light sniff, etc. 

 

Insulin is a 51 amino acid peptide that is broken down in the digestive tract. That's why diabetics have to inject it. Swallowing a little won't cause any problems. 

 

Also, I definitely recommend increasing slowly (10IU at a time) but you can go all the way up to 160IU in a day (40IU, 4x per day). This has been tested multiple times in healthy humans without side effects. I've done this without any problems but I didn't notice enough of a difference to justify spending the extra money it would cost to do this daily.

 

The main idea is that you have a lot of dosing options to test out before determining whether INI works for you or not. You can vary amount per dose, amount per day, times of day that you dose (at meal times, before bed, first thing in the morning, etc), etc. There are countless options. I've seen a few redditors try two different dosing patterns on two different days, notice no effects, throw their hands up in the air, and claim that INI is worthless. ha

 

When I test out a substance I'll try dozens of doses and patterns over the course of many different time periods (weeks, months, etc.) before I decide whether it works for me or not. I hope you're able to find an INI dose that works well for you!

 

https://youtu.be/kHeYBUltC34?t=2m27s

Edited by lostfalco, 02 January 2017 - 03:56 PM.

[mkmossop]

That video helps a lot... thank you for that. I didn't know that insulin was a peptide. Good to know that it gets digested.

I'm definitely not giving up yet... I'll give it a few weeks and try a few different dosing patterns. I don't think I've been spraying it correctly either til now so hopefully that will make a difference.

Thanks for your help again .

[lostfalco]

That video helps a lot... thank you for that. I didn't know that insulin was a peptide. Good to know that it gets digested.

I'm definitely not giving up yet... I'll give it a few weeks and try a few different dosing patterns. I don't think I've been spraying it correctly either til now so hopefully that will make a difference.

Thanks for your help again .

You're very welcome!

[Valijon]

8 sprays a day is a lot from what I've read. Imdont think SNIFF went beyond 4 per day. Does anyone know a place with Wal-Mart prices that sells Novalin R online? I have no way to get anywhere at the moment. Itd be great to find something in the 30 to 40 range with shipping.