thinking outside the box - depression, ocd, add
#31
Posted 16 June 2013 - 07:49 AM
#32
Posted 16 June 2013 - 08:08 AM
http://onlinelibrary...0267.x/abstract
Also in regards to ADD i don't know if i've mentioned metadoxine as a non stimulant treatment in phase 2 trials. It is available online very cheaply, here's the phase ll trial
http://europepmc.org...ct/MED/23290324
and in regards to ocd, ondansetron(which i've tried with some success) success was very specific to ocd-like symptoms but again ondansetron has been linked to possible increase in heart problems(via promiscuous herg i think) anyway heres a pilot trial for ocd there are a few more out there as well.
http://europepmc.org...ct/MED/14628977
Edited by socialpiranha, 16 June 2013 - 08:22 AM.
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#33
Posted 16 June 2013 - 12:04 PM
Do you (or any others on here) have any experience with Stablon (Tianeptine) I know there's some threads from a while back, but just curious what some of the latest thought is on it? looks like some good sources to pick this up from. I've read some good info on it...
Anyway, be curious to read some thoughts on this.
D
#34
Posted 16 June 2013 - 02:14 PM
#35
Posted 16 June 2013 - 02:29 PM
Just trying to find something (besides clonzeapam) that i can take everyday. Currently trying Lithium Orotate, but trying to find the right dosage. Not sure Li-Or will be enough, that's why I'm looking for something else.
Tried most of the Russian stuff and most of the herb/nutriceutical approaches...Still on the quest.
#36
Posted 16 June 2013 - 03:21 PM
I'm actually starting a drug called mildronate monday that is supposed to help the heart by affecting mitochondrial respiration. Studies show that it increases energy and mood in neurological disorders.
http://onlinelibrary...0267.x/abstract
Also in regards to ADD i don't know if i've mentioned metadoxine as a non stimulant treatment in phase 2 trials. It is available online very cheaply, here's the phase ll trial
http://europepmc.org...ct/MED/23290324
and in regards to ocd, ondansetron(which i've tried with some success) success was very specific to ocd-like symptoms but again ondansetron has been linked to possible increase in heart problems(via promiscuous herg i think) anyway heres a pilot trial for ocd there are a few more out there as well.
http://europepmc.org...ct/MED/14628977
thanks for the studies .. ondanestron is available here, but it's ridiculously expensive (a 4-pill pack for nausea cost me like $30). my ocd/phobic avoidance is so severe and disruptive that it's literally occupying most of my daily routine, and yet i really don't want to be on SSRIs, APs, etc. starting to feel pretty hopeless. i really wish there were better alternatives out there. i was born 10 years too late.
#37
Posted 17 June 2013 - 01:57 AM
Lucky, i wish i was legally allowed to send you what i have left of the ondansetron, i spent over 300 bucks on it and its just sitting in my bag of old meds. If you haven't tried it yet i would highly suggest it given your symptoms. It does something no other drug i've tried does, it quiets something in the body/brain that no other drug i've tried does(possibly via the vagus nerve) It is in no way euphoric and has no effect on depression but it definitely has a very noticable effect on ocd-like symptoms even with the first dose. My primary symptom is socially anxiety which it doesnt have much effect on, i'm ok when i'm at home.
10 years too late for what?
As a last resort i would recommend buprenorphine, It completely obliterates ocd and depression and is helpful for anxiety.
#38
Posted 17 June 2013 - 02:19 PM
i just meant 10 years as in i'm guessing all the exciting developments will happen over the next decade ..
sadly i'm in neo-fascist australia where prescribing opiates off-label is illegal -- unless i turn up to a clinic with holes punctured into my arm, i have zero chance of having buprenorphine prescribed.
#39
Posted 17 June 2013 - 02:25 PM
I believe you mentioned in a previous post that you were taking Lithium orotate and that it was helping a bit. If this is correct, how much do you take? I have ramped it up a bit recently to 25mg a day (5 pills) and I can feel it some.
D
#40
Posted 17 June 2013 - 02:42 PM
i take 5mg a day .. it helps anxiety a little and flattens my mood a bit. i just took 10mg about an hour ago as a matter of fact and the anxiolytic effect is stronger, but i feel way more mentally foggy
#41
Posted 17 June 2013 - 03:29 PM
I've been spacing the pills out over 2-3 hours over each day to try to get a more even effect. I can feel some anxiolytic effect after a 5mg pill, but it doesn't seem to last all that long.
I know there are some reports of people taking up to 40mg a day in divided dose. I believe Dr. Jonathan Wright says he'll recommend up to that much without needing to be concerned about toxicity, etc.
#42
Posted 18 June 2013 - 03:56 PM
I'm gonna be ordering jdtic soon its a kappa antagonist like buprenorphine available online, it has potent anti anx/dep/ocd effects according to anecdotal reports.I have used many other opiates with no where near the remission that bupe gave me(hence the kappa theory) There are some studies which lend some evidence toward the idea that ocd/anx could be treated with kappa ants
http://www.ncbi.nlm....pubmed/17907829
http://repository.up...ons/AAI3395683/
#43
Posted 19 June 2013 - 08:35 AM
i've used ginger for nausea and never really noticed anything
unfortunately i don't really have enough money at the moment to experiment with novel, non-prescription compounds.
have you ever tried antibiotics socialpiranha? i know they're more indicated in PANDAS. minocycline seems to be getting attention for depression lately, but not sure if it shows much benefit in ocd/anxiety
#44
Posted 20 June 2013 - 05:58 AM
have you tried it? do you happen to know any affordable sources? the best i found was $350US for a month's supply
#45
Posted 02 July 2013 - 11:11 PM
I realized you haven't yet tried T3 which is clearly indicated in the pathophysiology of atypical depression. Nor could I find mention of Modafinil which has few but very promising studies in atypical depression. In reality you would want to be taking this with a Serotonergic antidepressant of some description. The combination is unlikely to worsen your anxiety much although in the first few weeks this might be a problem. In which case a PRN for something sedating might be in order.
This could give rise to a potentially very powerful combination of SSRI (other antidepressant, maybe meclobremide?), T3 and Modafinil. I feel like this is a much more promising and evidence based possibility than Riluzole. Start the SSRI add in modafinil after two weeks, keeping the doses low to start with and then add in high dose T3 before slowly increasing the doses of modafinil and the SSRI
#46
Posted 03 July 2013 - 12:37 AM
Hey Tom_ T3 is a good suggestion, i don't really agree with the modafinil suggestion tho, it has extremely limited usefulness in my experience.
#47
Posted 03 July 2013 - 02:05 PM
#48
Posted 03 July 2013 - 10:35 PM
Edited by socialpiranha, 03 July 2013 - 10:46 PM.
#49
Posted 04 July 2013 - 01:51 AM
What website reliably offers Metadoxine? I couldn't find any :(Also in regards to ADD i don't know if i've mentioned metadoxine as a non stimulant treatment in phase 2 trials. It is available online very cheaply, here's the phase ll trial
http://europepmc.org...ct/MED/23290324
#50
Posted 04 July 2013 - 10:33 AM
I'm all for stereotyping, the antistereotype movement disgusts me. What I'm not for is people making un-evidence based or value judgements. You should be allowed to say: in the USA Black people are more violent than other groups. You shouldn't be allowed to say: you're black you must be a mass murdering fuck head...lets hang him boys.
#51
Posted 04 July 2013 - 09:26 PM
#52
Posted 04 July 2013 - 09:34 PM
What website reliably offers Metadoxine? I couldn't find any :(Also in regards to ADD i don't know if i've mentioned metadoxine as a non stimulant treatment in phase 2 trials. It is available online very cheaply, here's the phase ll trial
http://europepmc.org...ct/MED/23290324
unitedpharmacies(viboliv) and ospharma(abrixone) brand names in brackets
#53
Posted 05 July 2013 - 01:50 AM
Holy shit thanks!! I can't believe I couldn't find it before. Metadoxine was on my mind for several months now. I thought it just vanished. I would absolutely love to try it but the data (pharmacology) behind it is unknown. I don't know how this will interact with my upcoming stack and there aren't any anecdotes either. Why aren't you trialing it? It's interesting how the effects weren't noticeable til week 2 of treatment. Also, Metadoxine is a pyrolate salt of Pyridoxine (Vitamin B6).unitedpharmacies(viboliv) and ospharma(abrixone) brand names in brackets
Edited by KoolK3n, 05 July 2013 - 02:46 AM.
#54
Posted 05 July 2013 - 04:29 PM
I appreciate the suggestion Tom, but there seems to be a limit to what serotonin-reuptake is going to do for me. I'd revisit an SSRI if there was nothing else left, but they do very little for my depression, anxiety or OCD and just make my ADD worse. plus I've experienced akathisia and movement symptoms on every one to date, which makes most practitioners reluctant to prescribe them and leaves me concerned about long-term effects.
maybe I'm being unrealistic, but I'm really looking for a robust clinical improvement at this point. this disease has stolen over 7 years of my life.
#55
Posted 05 July 2013 - 04:45 PM
#56
Posted 05 July 2013 - 04:55 PM
Edited by lucky.pierre, 05 July 2013 - 04:56 PM.
#57
Posted 07 July 2013 - 02:57 AM
After a while the motivation is drained and only a drastic improvement can turn things around, a slight reduction in symptoms often isn't worth the side effects that come with it or enough to turn things around.
I really like the treading water analogy because it is really very pertinent to the human condition. When your struggling to keep your head above water and someone throws you a life preserver, you can grab it and desperately hold onto it until you can regain your strength. When your already below the surface and out of reach it wouldn't be any help at all, at this point you would need someone to jump in and save you...
Failed treatment is an elongated version of this it is a slow drowning, grasping at less and less as time goes on as your strength fades. Only something with robust effects can summon up the strength to reach out at a certain point.
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#58
Posted 07 July 2013 - 03:56 AM
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