13 replies to this topic

[HeyItsMeLC]

Hi Forum,

I am looking to start supplementing with L-Tyrosine in hopes of boosting dopamine levels. I understand this is far from a certainty but its worth a shot based on reviews.

Couple questions:

• It just occurred to me that Tyrosine might work synergistically with L-Theanine to increase CNS dopamine. Does this have potential? Anyone tried this combination?
• It seems that tolerance with Tyrosine is a real issue for many. What would be the best way to cycle? I was thinking 5 days on, 2 off...
• This might be broscience as my knowledge is very limited on this subject - but would it be a good idea to cycle Tyrosine with Sulbutiamine, that way you would get a type of Yin & Yang effect of increase DA with Tyrosine and D1 receptor up-regulation as a result of Sulbutiamine?

Peace

Edited by HeyItsMeLC, 09 June 2013 - 07:07 AM.

[HeyItsMeLC]

Just bumping to get some feedback, any pointers appreciated!

[DbCooper]

Bump. Good question

[Ukko]

Tyrosine is prone to causing anxiety. Think of it as caffeine. Stuff you can do to boost your dopamine receptor sensitivity:

1) CDP-choline / uridine
2) Alpha lipoic acid / NAC
3) Inositol (big doses 10-20g)
4) Threonate, dehydroascorbic acid, ascorbic palmitate (yes, this are related to vitamin C)
5) Zinc (dopamine reuptake inhibitor)

Not sure sulbutiamine or theanine will do a lot. Am taking both though for nootropic purposes.

[HeyItsMeLC]

Thank you Ukko, will look into those about receptor sensitivity.

Anyone else has a more direct answer to the original post?

[HeyItsMeLC]

Hi all,
Did not want to start another thread cuz I thought it would be spamming the forum...

Question: Started Tyrosine today for the first time. Shortly after ingesting (standard 500mg dose) my heart rate shot up to 100+ and remained elevated in the tachycardia range for a long time, getting close to 7 hours now. Obviously, this lead to a major increase in anxiety and lead me to check my pulse obsessively. Does this mean that my body converts too much dopamine to norepinephrine?

Edited by HeyItsMeLC, 26 June 2013 - 05:42 AM.

[Ukko]

Again, even though I am not answering your specific question, seriously consider sensitizing your dopamine receptors and increasing their amount. Honestly, tyrosine, PEA and NALT are like caffeine in my experience. And that is neither good nor sustainable.

[lammas2]

Again, even though I am not answering your specific question, seriously consider sensitizing your dopamine receptors and increasing their amount. Honestly, tyrosine, PEA and NALT are like caffeine in my experience. And that is neither good nor sustainable.

Are you using all (or some) of the dopamine receptor sensitivity boosting things you mentioned? I mean, there is some evidence that CDP-choline and inositol increase dopamine receptor sensitivity, but can you really FEEL the enhanced dopaminergic function?

[HeyItsMeLC]

Again, even though I am not answering your specific question, seriously consider sensitizing your dopamine receptors and increasing their amount. Honestly, tyrosine, PEA and NALT are like caffeine in my experience. And that is neither good nor sustainable.

Ok, but I would also like to use Tyrosine, even just as a nootropic. I am concerned about my reaction to it, the only other supps I used that day were Fish Oil and Rhodiola. Do you know if it is dangerous to combine Tyrosine with a reversible MAOI such as Rhodiola?

[Ukko]

Again, even though I am not answering your specific question, seriously consider sensitizing your dopamine receptors and increasing their amount. Honestly, tyrosine, PEA and NALT are like caffeine in my experience. And that is neither good nor sustainable.

Are you using all (or some) of the dopamine receptor sensitivity boosting things you mentioned? I mean, there is some evidence that CDP-choline and inositol increase dopamine receptor sensitivity, but can you really FEEL the enhanced dopaminergic function?

Totta vitussa olen Eli siis, yes you can feel it to a degree. Also more sustainable over the long term. Improves over time, does not taper off. Nauti helteesta Lammas!!!

Again, even though I am not answering your specific question, seriously consider sensitizing your dopamine receptors and increasing their amount. Honestly, tyrosine, PEA and NALT are like caffeine in my experience. And that is neither good nor sustainable.

Ok, but I would also like to use Tyrosine, even just as a nootropic. I am concerned about my reaction to it, the only other supps I used that day were Fish Oil and Rhodiola. Do you know if it is dangerous to combine Tyrosine with a reversible MAOI such as Rhodiola?

Probably not for the short term. Long term, you'd likely desensitize your dopamine receptors. Think of it as getting addicted to coffee. A new normal or a new baseline gets established. Then you need that combo just to feel normal.

[Ukko]

Sharing one more dopamine receptor sensitizer with you guys....forskolin....check it out.

[HeyItsMeLC]

Thanks for that Ukko, maybe thats why forskolin also increases sex drive?

Heres a study.

Molecular mechanisms underlying forskolin-mediated up-regulation of human dopamine D2L receptors.
Wanderoy MH, Westlind-Danielsson A.
Source
Department of Biochemistry, CNS Preclinical R&D, Astra Arcus AB, Södertälje, Sweden.
http://www.ncbi.nlm..../pubmed/9353595


And another...

Forskolin stimulates the conversion of tyrosine to dopamine in catecholaminergic neural tissue

• Ira R. Katz,
• Diane Smith^b,
• Maynard H. Makman^a

• ^a Departments of Biochemistry and Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
• ^b Departments of Psychiatry and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
  http://www.sciencedi...006899383911393

Edited by HeyItsMeLC, 28 June 2013 - 04:43 AM.

[Ukko]

Foreskinolin. Yeah, does that too.

[Ukko]

By the way....see the beauty in that? Boosts both production of dopamine as well as maintains sensitivity to it. Nice. And you get to save the BBB transporter molecules to haul some other stuff into the brain than just tyrosine alone