9 replies to this topic

[Perception-Is-Reality]

Whats your opinion on taking 25-50mg/day of amisulpride in addition to an adderall/memantine regime? The effect i am looking for is a long term increase in dopamine.

[Tom_]

Amisulpride reduces dopamine.

Also they all have primary mechanisms of actions in very different areas of the brain. The Amisulpride will blunt adderall slightly and vice verca but thats all.

[Perception-Is-Reality]

are you sure this occurs in low doses where the dopamine antagonism is still selective?

[Tom_]

I believe amisulpride is selective at all doses (may be wrong). However even if it is selective its still selective antagonism.

[Perception-Is-Reality]

ur J Pharmacol. 1998 Apr 10;346(2-3):331-7.
Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells.

Ratomponirina C, Gobaille S, Hodé Y, Kemmel V, Maitre M. Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires, UPR 416 CNRS, Strasbourg, France.

Five days of gamma-hydroxybutyrate (GHB) administration (3 x 500 mg kg(-1) day(-1) i.p.) to rats resulted in a significant decrease in the density of GHB receptors measured in the whole rat brain without modification of their corresponding affinity. Similar administration of (-)-sulpiride (2 X 100 mg kg(-1) day(-1) i.p. for 5 days) induces an up-regulation of GHB receptors without change in their dissociation constants (Kd). Haloperidol (2 X 2 mg day(-1) i.p. for 5 days) showed no effect. Administered chronically via osmotic minipumps directly into the lateral ventricles, (-)-sulpiride (60 microg day(-1) for 7 days) and GHB (600 microg day(-1) for 7 days) up-regulated and down-regulated rat brain GHB receptors, respectively. Finally, in a mouse hybridoma cell line (NCB-20 cells) expressing GHB receptors, the treatment of these cells with 1 mM GHB, 100 microM (-)-sulpiride or 1 mM GABA decreases, increases and induces no change, respectively, in the density of GHB receptors after 3 days of treatments. These results indicate that chronic GHB treatment modifies the expression of its receptor and that sulpiride also induces plastic changes in GHB receptors perhaps via antagonistic properties.
sulpiride just as amisulpride can be used as an antidepressant in low doses (as it only blocks the presynaptic dopamine receptors, thus increasing the ammount of dopamin, those 2 are also reported to be helpfull with social anxiety). So that means that sulpiride/amisulpride selectively antagonize d2-autoreceptors, at least in moderate doses, to boost dopamine-release (without blockade of postsynaptic dopamine-receptors like common neuroleptics) and therefore should be lifting mood and generally be reinforcing (in theory).

[arjacent]

Amisulpride at low doses antagonizes PRE-synaptic receptors which are inhibitory, thus increasing dopamine transmission. In theory this would make your D2 receptors very active as the memantine would agonize only postsynaptic receptors as would all the extra dopamine. The only drawback is amisulpride raises prolactin so they may decrease some of the stimulation. The only real problem I see is polypharmacy which would be problematic only if the same enzymes are metabolising the drugs.

[Perception-Is-Reality]

Amisulpride at low doses antagonizes PRE-synaptic receptors which are inhibitory, thus increasing dopamine transmission. In theory this would make your D2 receptors very active as the memantine would agonize only postsynaptic receptors as would all the extra dopamine. The only drawback is amisulpride raises prolactin so they may decrease some of the stimulation. The only real problem I see is polypharmacy which would be problematic only if the same enzymes are metabolising the drugs.

Your post was vary informative, thank you. As far as prolactin i believe effects will be minimal due to the dosage, 25-50mg when over 1000mg is commonly used for antipsycosis, which btw is great as far as money is concerned i can split a 400 mg pill into 8-16 doses. I dont think polypharmacy will be an issue, the brain adapts to almost anything. If two things are metabolized by one enzyme my body will produce more of that enzyme to compensate, just as those on maoi medication eventully find their maoi's ineffective at the same dose, the brain compensates to having its mao A and/or B receptors being continually knocked out.

[arjacent]

Your post was vary informative, thank you. As far as prolactin i believe effects will be minimal due to the dosage, 25-50mg when over 1000mg is commonly used for antipsycosis, which btw is great as far as money is concerned i can split a 400 mg pill into 8-16 doses. I dont think polypharmacy will be an issue, the brain adapts to almost anything. If two things are metabolized by one enzyme my body will produce more of that enzyme to compensate, just as those on maoi medication eventully find their maoi's ineffective at the same dose, the brain compensates to having its mao A and/or B receptors being continually knocked out.

The body indeed adapts to almost anything, which is why it wouldn't take long for you to develop tolerance to amisulpride as pre-synaptic receptors upregulate. I would exclude amisulpride and let your body naturally regulate receptors. That is not to say you couldn't use it sporadically for an extra dopamine "kick". Raised prolactin occurs even in low doses, this is largely the reason the drug isn't used in North America.

[Perception-Is-Reality]

Your post was vary informative, thank you. As far as prolactin i believe effects will be minimal due to the dosage, 25-50mg when over 1000mg is commonly used for antipsycosis, which btw is great as far as money is concerned i can split a 400 mg pill into 8-16 doses. I dont think polypharmacy will be an issue, the brain adapts to almost anything. If two things are metabolized by one enzyme my body will produce more of that enzyme to compensate, just as those on maoi medication eventully find their maoi's ineffective at the same dose, the brain compensates to having its mao A and/or B receptors being continually knocked out.

The body indeed adapts to almost anything, which is why it wouldn't take long for you to develop tolerance to amisulpride as pre-synaptic receptors upregulate. I would exclude amisulpride and let your body naturally regulate receptors. That is not to say you couldn't use it sporadically for an extra dopamine "kick". Raised prolactin occurs even in low doses, this is largely the reason the drug isn't used in North America.

darn, it appears the raise in proctin is independent of dosage. Oh well if i would build tolerance fast i dont want this, im looking for things useful day 100 not just day 1-3.

Your post was vary informative, thank you. As far as prolactin i believe effects will be minimal due to the dosage, 25-50mg when over 1000mg is commonly used for antipsycosis, which btw is great as far as money is concerned i can split a 400 mg pill into 8-16 doses. I dont think polypharmacy will be an issue, the brain adapts to almost anything. If two things are metabolized by one enzyme my body will produce more of that enzyme to compensate, just as those on maoi medication eventully find their maoi's ineffective at the same dose, the brain compensates to having its mao A and/or B receptors being continually knocked out.

The body indeed adapts to almost anything, which is why it wouldn't take long for you to develop tolerance to amisulpride as pre-synaptic receptors upregulate. I would exclude amisulpride and let your body naturally regulate receptors. That is not to say you couldn't use it sporadically for an extra dopamine "kick". Raised prolactin occurs even in low doses, this is largely the reason the drug isn't used in North America.

darn, it appears the raise in proctin is independent of dosage. Oh well if i would build tolerance fast i dont want this, im looking for things useful day 100 not just day 1-3.

[Perception-Is-Reality]

Your post was vary informative, thank you. As far as prolactin i believe effects will be minimal due to the dosage, 25-50mg when over 1000mg is commonly used for antipsycosis, which btw is great as far as money is concerned i can split a 400 mg pill into 8-16 doses. I dont think polypharmacy will be an issue, the brain adapts to almost anything. If two things are metabolized by one enzyme my body will produce more of that enzyme to compensate, just as those on maoi medication eventully find their maoi's ineffective at the same dose, the brain compensates to having its mao A and/or B receptors being continually knocked out.

The body indeed adapts to almost anything, which is why it wouldn't take long for you to develop tolerance to amisulpride as pre-synaptic receptors upregulate. I would exclude amisulpride and let your body naturally regulate receptors. That is not to say you couldn't use it sporadically for an extra dopamine "kick". Raised prolactin occurs even in low doses, this is largely the reason the drug isn't used in North America.

darn, it appears the raise in proctin is independent of dosage. Oh well if i would build tolerance fast i dont want this, im looking for things useful day 100 not just day 1-3.