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Mifepristone for Depression & HPA axis Dysfunction

hpa axis mifepristone

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#151 Geoff1892

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Posted 27 December 2018 - 09:49 PM

Are you following a specific protocol? I thought only one single dose was needed?



Hey John,

Although it looks like I recently joined longecity, I actually have an old profile that no longer works. I still get notifications everyone writes on topic i follow. My name was “Madhacker”, and you can see my posts above.

I’m going to do you a favour in what you’re looking for on this topic and save you a lot of time. I’ve had HPA dysfunction for over a decade and I tried to hack it on my own. Spent tons of money and caused myself more problems than not. I tried Mifepristone, spent a fortune on the stuff, only to have it fail on me. I will start by saying you should not waste your time on this stuff because HPA dysfunction can be degenerative and you’re on HRT. If you want to stop taking TRT and HGH and take this shit for your HPA dysfunction it still will not work.
I have a few questions, how do you know the amphetamines caused damage? Do you have labs showing it’s primary or secondary problems? Are you producing to much ACTH indicting a secondary or is the gland not producing enough ACTH?
At 1iu hgh suppresses ACTH by up to 30% after a month of treatment. After 6 months are participants show suppression of ACTH by at least 30%. TRT suppresses cortisol in the long run as well.

In your case first I would find out the problem, primary or secondary. Second if you are to stay on HRT (which you should) you should consider taking 0-2mg of growth hormone with 0-.5mg of IGF. (Lower the dose by 10x for IGF LR3.) You should have your IGF levels up to at least 300 but to do that you have shown that you need to take to high of a dose. Take thyroid, testosterone, progesterone, melatonin, and other hormones to optimal ref. ranges.
Those are the basics... Now you need to raise cortisol and get a rhyme.
1) pregnenolone at least 100mg
2) pregnenolone 50mg and 20mg of progesterone
3) take LDN. Takes weeks to stimulate the pituitary.
4) take adrenal Cortex or hydrocortisone

Cortisol is more important than you think. If it’s not in optimal ranges you increase your risk of mortality by 30%.
Also watch the Anabolics many block cortisol signaling as they compete with androgen receptors. Look into every single on before taking it to see if it does that before deciding on one. I wish I had.

#152 John250

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Posted 29 December 2018 - 12:15 AM


Hey John,

Although it looks like I recently joined longecity, I actually have an old profile that no longer works. I still get notifications everyone writes on topic i follow. My name was “Madhacker”, and you can see my posts above.

I’m going to do you a favour in what you’re looking for on this topic and save you a lot of time. I’ve had HPA dysfunction for over a decade and I tried to hack it on my own. Spent tons of money and caused myself more problems than not. I tried Mifepristone, spent a fortune on the stuff, only to have it fail on me. I will start by saying you should not waste your time on this stuff because HPA dysfunction can be degenerative and you’re on HRT. If you want to stop taking TRT and HGH and take this shit for your HPA dysfunction it still will not work.
I have a few questions, how do you know the amphetamines caused damage? Do you have labs showing it’s primary or secondary problems? Are you producing to much ACTH indicting a secondary or is the gland not producing enough ACTH?
At 1iu hgh suppresses ACTH by up to 30% after a month of treatment. After 6 months are participants show suppression of ACTH by at least 30%. TRT suppresses cortisol in the long run as well.

In your case first I would find out the problem, primary or secondary. Second if you are to stay on HRT (which you should) you should consider taking 0-2mg of growth hormone with 0-.5mg of IGF. (Lower the dose by 10x for IGF LR3.) You should have your IGF levels up to at least 300 but to do that you have shown that you need to take to high of a dose. Take thyroid, testosterone, progesterone, melatonin, and other hormones to optimal ref. ranges.
Those are the basics... Now you need to raise cortisol and get a rhyme.
1) pregnenolone at least 100mg
2) pregnenolone 50mg and 20mg of progesterone
3) take LDN. Takes weeks to stimulate the pituitary.
4) take adrenal Cortex or hydrocortisone

Cortisol is more important than you think. If it’s not in optimal ranges you increase your risk of mortality by 30%.
Also watch the Anabolics many block cortisol signaling as they compete with androgen receptors. Look into every single on before taking it to see if it does that before deciding on one. I wish I had.


I had a 4 part saliva cortisol test and all my levels were normal. I never had ACTH tested though I’ll do that next. I have a feeling my adrenal issues are amphetamine related. It may not even be adrenals it may be I’m just so burnt out from them. Maybe I’ll just get this test done to rule it out.

https://www.walkinla...blood-test.html

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#153 Geoff1892

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Posted 13 January 2019 - 01:40 AM

I had a 4 part saliva cortisol test and all my levels were normal. I never had ACTH tested though I’ll do that next. I have a feeling my adrenal issues are amphetamine related. It may not even be adrenals it may be I’m just so burnt out from them. Maybe I’ll just get this test done to rule it out.

https://www.walkinla...blood-test.html

 

If you're cortisol is okay, you're adrenals should be okay but keep us posted on your ACTH. 

What are your symptoms? 

 



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#154 John250

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Posted 15 January 2019 - 02:19 AM

If you're cortisol is okay, you're adrenals should be okay but keep us posted on your ACTH.

What are your symptoms?


Symptoms are extreme fatigue and less I’m flooded with amphetamines.

Anxiety, depression, and major major procrastination

#155 Geoff1892

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Posted 15 January 2019 - 03:11 AM

Symptoms are extreme fatigue and less I’m flooded with amphetamines.

Anxiety, depression, and major major procrastination


Have you seen an integrative doctor, how’s your thyroid levels? Your T3 levels aren’t in the upper 75th percentile.
Is your fatigue worse when resting? Is it harder to get up and going after sitting or resting?
If you have all day fatigue cortisol, dopamine or other neurotransmitters should be looked into. Unless it’s more unlikely problems such as mitochondrial.

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#156 John250

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Posted 15 January 2019 - 06:13 AM

Have you seen an integrative doctor, how’s your thyroid levels? Your T3 levels aren’t in the upper 75th percentile.
Is your fatigue worse when resting? Is it harder to get up and going after sitting or resting?
If you have all day fatigue cortisol, dopamine or other neurotransmitters should be looked into. Unless it’s more unlikely problems such as mitochondrial.


Thyroid was always good with T3 being in the upper range but still in range and a normal TSH and other thyroid values. That was with and without HGH. Fatigue is not worse when resting it’s pretty much the same. I find at night I get more energy so I think my circadian rhythm is off.




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