17 replies to this topic

[pedr0vsky]

Does anyone knows why phenylpiracetam is limited to 750 mg daily? I am thinking in going higher.

[Nattzor]

Who says it's limited to 750 mg per day?

[3AlarmLampscooter]

750mg sounds like a lot. Although that may be enough to induce tolerance quickly. I stick to 200mg every other day, and don't have tolerance issues.

[pedr0vsky]

750mg sounds like a lot. Although that may be enough to induce tolerance quickly. I stick to 200mg every other day, and don't have tolerance issues.

I have high tolerance.


Trade name: fenotropil ® (PHENOTROPIL ®)
Chemical name: N-methyl-carbamoyl-4-phenyl-2-pyrrolidone
Pharmacological properties
Pharmacotherapeutic group: nootropics
Pharmacodynamics. Fenotropil ^® - nootropic drug has a strong antiamnestic action has a direct activating effect on integrative activity of the brain, helps to consolidate memory, improves concentration and mental performance, facilitates the learning process, increases the speed of information transfer between the hemispheres of the brain, increases the resistance of the tissues the brain to hypoxia and toxic effects, has anticonvulsant activity and anxiolytic activity, regulates the activation and inhibition of CNS, improves mood.
Fenotropil ^® has a positive effect on metabolism and blood circulation of the brain, stimulates the oxidation-reduction processes, increases the body's energy potential through the utilization of glucose, and improves regional blood flow in the ischemic regions of the brain. Increases of noradrenaline, dopamine and serotonin in the brain, has no effect on the levels of GABA, is not associated with either the GABA A or GABA B receptors with, has no appreciable effect on the spontaneous bioelectric activity of the brain.
Fenotropil ^® has no effect on respiration and cardiovascular system, shows ulterior diuretic effect , has anoreksigennoy activity in the exchange application.
The stimulatory effect of Phenotropil ^® manifested in its capacity to moderately pronounced effect on motor reactions in enhancing exercise performance in a pronounced antagonism cataleptic action of neuroleptics, and in reducing the expression of hypnotic action ethanol and hexenal.
Stimulating effect fenotropil ^® ideatornoy prevails in the area . Moderate inducing effect of the drug is combined with anxiolytic activity, improves mood, has some analgesic effect, raising the pain threshold.
Adaptogenic effect fenotropil ^® is to increase the body's resistance to stress in the face of excessive mental and physical fatigue while, hypokinesia and immobilization at low temperatures.
At a reception fenotropil ^® marked improvement in vision, which results in increased sharpness, brightness and field of view.
Fenotropil ^® improves blood flow to the lower extremities.
Phenotropil ^® stimulates antibody production in response to the antigen, indicating that its immunostimulatory properties, but at the same time, it is not conducive to the development of immediate hypersensitivity or allergic inflammatory response changes of the skin caused by introduction of foreign protein.
In exchange application fenotropil ^® does not develop drugdependence, tolerance, "withdrawal".
Action fenotropil ^® is manifested with a single dose, which is important when using the drug in extreme conditions.
Fenotropil ^® has no teratogenic, mutagenic, carcinogenic and embryotoxic properties. Toxicity - low lethal dose in acute experiment was 800 mg / kg.
Pharmacokinetics . Fenotropil ^® is rapidly absorbed, penetrates into the various organs and tissues, readily passes through the blood-brain barrier. The absolute bioavailability after oral administration of 100%. The maximum concentration in the blood is reached in 1 hour half-life of 3-5 hours. Fenotropil ^® is not metabolized in the body and is excreted unchanged.Approximately 40% of the drug is excreted in urine and 60% of the drug is excreted in the bile and then.INDICATIONS

• Diseases of the central nervous system of various origins , especially those associated with vascular diseases and disorders of metabolic processes in the brain, intoxication (particularly in post-traumatic states and phenomena of chronic cerebrovascular insufficiency), accompanied by a deterioration of intellectual-mental function, decreased physical activity;
• Neuroticism , manifested apathy, excessive exhaustion, decreased psychomotor activity, in violation of attention, memory impairment;
• Violations of learning processes ; depression of mild to moderate severity ; Psihorganicheskie syndromesseen intellectual and memory impairment apatiko-abulicheskimi phenomena, as well vyaloapaticheskie state of schizophrenia;
• Convulsive status ;
• Obesity (alimentary-constitutional origins);
• Prevention of hypoxia , increased resistance to stress, functional correction of the body in extreme conditions of professional activity in order to prevent the development of fatigue and improve mental and physical performance, correction of daily biorhythms, the inversion of the cycle "sleep-wake";
• Chronic alcoholism (in order to reduce the phenomena of fatigue, depression, intellectual-mental disorders).

CONTRAINDICATIONS

Individual intolerance.PRECAUTIONS

Fenotropil ^® is used with caution in patients with severe organic lesions of the liver and kidneys, severe arterial hypertension, in patients with atherosclerosis, and in patients who have had previous panic attacks, anxiety raptoidnye state or acute psychotic states, especially agitated because of the possibility of acute anxiety , panic, hallucinations and delusions, as well as in patients who are prone to allergic reactions to drugs of nootropic pyrrolidone.Pregnancy and Lactation

Fenotropil ^® should not be administered during pregnancy and lactation because of the lack of clinical trial data.USE IN PEDIATRICS

Not recommended the appointment of Phenotropil ^® children, due to lack of data of the drug in children.DOSAGE AND ADMINISTRATION

Fenotropil ^® is administered orally, immediately after a meal. Dose and duration of treatment should be determined by your doctor. Doses vary depending on the characteristics of the patient. The average single dose of 150 mg (100 mg to 250 mg), the average daily dose is 250 mg (200 mg to 300 mg). The maximum tolerated dose of - 750 mg per day. Recommended to divide the daily dose into 2 doses. The daily dose of 100 mg taken once in the morning, and more than 100 mg daily dose is divided into two stages. Duration of treatment may range from 2 weeks to 3 months. The average duration of treatment is 30 days. If necessary, the course may be repeated in a month.
To improve efficiency - 100-200 mg once in the morning for 2 weeks (for athletes - 3 days).
The recommended duration of treatment for patients with alimentary-constitutional obesity is 30-60 days at a dose of 100-200 mg once a day (in the morning).
Do not take Fenotropil ^® within 15 hours.SIDE EFFECTS

Insomnia (in the case of the drug within 15 hours). Some patients in the first 1-3 days of the drug may cause agitation, flushing of the skin, feeling of warmth, an increase in blood pressure.Overdose

No cases of overdose were reported. Treatment: symptomatic therapy.Interactions with other drugs

Fenotropil ^® may increase the effects of drugs that stimulate the central nervous system, anti-depressants and neuroprotective drugs.Cautions

When excessive psycho-emotional exhaustion by chronic stress and fatigue, chronic insomnia, acute administration fenotropil ^® on the first day can cause a sharp need for sleep. Such patients on an outpatient basis should be advised to start taking the drug in exchange holidays.RELEASE FORM

Tablets containing 50 mg or 100 Phenotropil ^® . 10 tablets in a blister of PVC film and aluminum foil.
Each jar, 1, 2 or 3 blisters, along with instructions for use in a pile of cardboard.STORAGE

List B. In a dry, protected from light and out of reach of children, at a temperature no higher than 30 0CSHELF LIFE

5 years. Not recommended for use after the expiration date.Pharmacy purchasing terms

By prescription.By the manufacturer

JSC "Shchelkovskiy Vitamin Plant",
141100, Schelkovo-1, Moscow region, st. Factory, 2.

Who says it's limited to 750 mg per day?

"The average single dose of 150 mg (100 mg to 250 mg), the average daily dose is 250 mg (200 mg to 300 mg). The maximum tolerated dose of - 750 mg per day."

[Nattzor]

"The average single dose of 150 mg (100 mg to 250 mg), the average daily dose is 250 mg (200 mg to 300 mg). The maximum tolerated dose of - 750 mg per day."

Well, the pira recommendation (from the producer) says max 24 g/day, there are a lot of people here who has done tons more.

[pedr0vsky]

"The average single dose of 150 mg (100 mg to 250 mg), the average daily dose is 250 mg (200 mg to 300 mg). The maximum tolerated dose of - 750 mg per day."

Well, the pira recommendation (from the producer) says max 24 g/day, there are a lot of people here who has done tons more.

Phenylpiracetam is 30 to 60 times stronger than piracetam . So that should make the maximum dosage of piracetam between 30x750mg=22500mg and 60x750mg=45000mg

I just wanted to know why the upper limit is 750mg so i can make a calculate mistake. phenylpiracetam is water soluble so it doesn't has a overdose dosage. I can't understand why the 750mg...

[Nattzor]

"The average single dose of 150 mg (100 mg to 250 mg), the average daily dose is 250 mg (200 mg to 300 mg). The maximum tolerated dose of - 750 mg per day."

Well, the pira recommendation (from the producer) says max 24 g/day, there are a lot of people here who has done tons more.

Phenylpiracetam is 30 to 60 times stronger than piracetam . So that should make the maximum dosage of piracetam between 30x750mg=22500mg and 60x750mg=45000mg

I just wanted to know why the upper limit is 750mg so i can make a calculate mistake. phenylpiracetam is water soluble so it doesn't has a overdose dosage. I can't understand why the 750mg...

The whole "x stronger than y" is just BS. Noopept is said to be 1000x stronger than piracetam, but they're not comparable. The dose is just set because they want to be sure no one takes big dosages and get side-effects. It's just a safety measure.

[xsiv1]

Although not stipulated, it may also mean that there is no evident therapeutic value beyond 750mgs total per day.

Also, just noticed that a Peak nootropics ad is below my post. Sorry to get off topic, but are they still in business? I could use some more phenylpiracetam and an always looking for competitive and reliable vendors in case one goes belly up.

[Introspecta]

Does anyone have an idea how long it may take to completely restore phenylpiracetam tolerance if indeed that is possible. Sometimes you can never get the initial effects. My last few times using phenyl left me somewhat irritable and really just not in the zone like normal. One time I dosed too high and another the good effects lasted about an hour. Anyone with experience that took a break then went back to get good results?

[xsiv1]

Does anyone have an idea how long it may take to completely restore phenylpiracetam tolerance if indeed that is possible. Sometimes you can never get the initial effects. My last few times using phenyl left me somewhat irritable and really just not in the zone like normal. One time I dosed too high and another the good effects lasted about an hour. Anyone with experience that took a break then went back to get good results?

I take breaks every week but I'm guessing you're looking for someone with experience taking a break after longer term consecutive day use...how many consecutive days have you used it? I know with Noopept they say you should take a 1 month break after two months of use..that is, if I'm remembering it correctly. With phenylpiracetam it also says to take a month off after a certain period of use.

[Introspecta]

I usually never use more than 3 days in a row then taking about 4-5 days off but that doesn't seem to be enough. I may just try a couple weeks off and see what happens. If I have to I may just take a few months off. I'm trying to get away from being dependent on supplements for good motivation. My energy's been getting better lately eating about 80% raw natural foods and about 20% cooked and processed. Taper down on caffiene too. Give my neurotransmitters a break.

[kilgoretrout]

So, is sub-lingual dosing really necessary? (tastes horrible). But I am not finding much info wrt 20-100 mg sublingual, vs. 150-300 mg swallowed in a capsule. I expected the different modes, which is preferred or necessary, would have been a prime topic. Any advice?

Edited by kilgoretrout, 01 January 2014 - 07:10 PM.

[kai2]

So, is sub-lingual dosing really necessary? (tastes horrible). But I am not finding much info wrt 20-100 mg sublingual, vs. 150-300 mg swallowed in a capsule. I expected the different modes, which is preferred or necessary, would have been a prime topic. Any advice?

Hi kilgortrout,

What difference have you noticed from taking it sublingually?

[pedr0vsky]

So, is sub-lingual dosing really necessary? (tastes horrible). But I am not finding much info wrt 20-100 mg sublingual, vs. 150-300 mg swallowed in a capsule. I expected the different modes, which is preferred or necessary, would have been a prime topic. Any advice?

Hi kilgortrout,

What difference have you noticed from taking it sublingually?

According to Wikipédia:
Routes Oral Pharmacokinetic data Bioavailability ~100 %


http://en.wikipedia....Phenylpiracetam

So, there isn't any benefit of sublingual administration.

[Neoracetam]

I find that even 100mg of Phenylpiracetam (one tablet) affects me, though I usually take 200mg throughout a day. You all seem to be taking much larger doses than that. Is anyone else in here affected by 100mg?

Now that I have the bulk powder, however, I'm probably going to experiment with 300mg per day.

[pinnacle]

300mg was my sweet spot. I once went up to a gram in a day but this was counterproductive. And of course, like everybody else, despite my best efforts tolerance ensued. The 1st few weeks are amazing . I was taking it every other day with no issues until about 2 months down the track. It just stops working.

In the beginning the effects were so pleasantly uplifting I would swear it felt dopaminergic.

Atter tolerance built up any attempt to achieve a good effect from it was followed rapidly by a crash and left me drained.

After a several month break I found it was still ineffective, except it did seem to aid a quick recovery from New Years when I started back a work.

[Neoracetam]

I’m still in that honeymoon phase, I think. I’ve found that 300mg is effective for me, though I can feel it at 100mg. I didn’t notice much of a difference between 400mg and 600mg. I think the effect feels the same after 400mg. Thanks for your reply. I’ll probably build up tolerance eventually, as you and the others have described. I’m going to record it all in my log as I go along. Thanks.

[mandaryn]

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