3 replies to this topic

[LIB]

What is the relationship with adrenals and SSRI's? I've read conflicting things. Some say that they will stimulate the adrenals and "burn them out". I've also read that they help regulate a dysfunctional HPA axis thus helping the adrenals.

Thanks.

[YOLF]

It probably has alot to do with the situation. Remember, medicine is given to people in cases where the benefits outweight the risks.

[PalmAnita]

Depends on the situation. If you are able to are able to live without an SSRI, I would highly recommend to try it w/o it ... there is a ton of other, less habit forming stuff that should been tried before a SSRI regimen gets started,

Since you're asking for adrenals, it's probably late, very late... maybe too late (if this is possible, pleeease correct me if possible, I'd love if it would be so).

At least I've come to the conclusion that if you're starting an SSRI and it's feeling like a stimulant / empthogenic the first days - this is a loud warning sign to immediately stop that serotonine shit, as it is your CNS telling you "there's aleredy enough of this stuff- what should we gonna do with all this extra ones?".... tolerance calling.

If it's lack of motivation you've fighting with, try low dosed psychostimulants (d-amph / lis-d-amph / carphedron etc.) ... maybe combined with 5-htp to stay balanced, or otne of the MAOIs - be it an irreversible or moclobemide (too few personal experiences here yet.) Another option could be Selegiline / L-Deprenyl, a selective MAO-B inhibitor. But (imo) nearly everything is better than long term usage of ssri antidepressants. Their withdrawal is different, but not much less intense than from your average opiate agonist ... takes week to week to normalize, really something I never wanna go through again and would like to help anyone as much as I can to ease the process ...

From my personal experience, (light) opiate habit was nothing compared to regular SSRI (Venlafaxine) use & withdrawal ... as the opiate w/d could be handled with Memantine, but for SSRi w/d symptoms there are just two options ... go through or take the next dose ... taking 5-.htp helps to a certain limit.

What's true is that SSRis fuck your mind's internal clock up ... with Paroxetine I did not sleep straight for nearly seven days even while taking Zopiclon at bedtime --> psychosis knocking at the door ... Serotonine on it's own is rather sedating. Don't know where this stimulating effect comes from, btw. how it interacts with adrenals.. here my biochemistry knowledge ends.

But ont last hint ... Melatonine, dosed right (>5mg), really helps ... If this is not strong enough, you could give the good old Clonidine (75-150 mcg in the evening) a try.

Edited by dopamimetiq, 07 August 2013 - 12:18 AM.

[nupi]

First, Venlafaxine is not an SSRI but an SNRI and has reputation of particularly bad withdrawals (I had none whatsoever back in the day, just goes to show how different people react to it). Second, there is another option besides going through and or taking the next dose. Cross-tapering to Flouxetine has repeatedly been shown to ease withdrawal a lot (Fluoxetine has such a long half life that any withdrawal will always be a very gradual process ).