All:
See:
The Postponement of Aging by Aubrey de Grey
Developing Biomedical Tools to Repair Molecular and Cellular Damage by Aubrey de Grey
These are, to my knowledge, Aubrey's first written presentations of his vision for the use of mature nanotechnology in engineered negligible senescence (1-3). The ultimate use of it to repair (rather than obviate, as via WILT for cancer (4)) nuclear mutations is of particular interest.
-Michael
1. de Grey AD.
An engineer's approach to the development of real anti-aging medicine.
Sci Aging Knowledge Environ. 2003 Jan 8;2003(1):VP1. Review.
PMID: 12844502 [PubMed - indexed for MEDLINE]
http://www.gen.cam.a...ens/focusPP.pdf
2. de Grey AD.
Challenging but essential targets for genuine anti-ageing drugs.
Expert Opin Ther Targets. 2003 Feb;7(1):1-5. PMID: 12556198 [PubMed - as supplied by publisher]
http://www.gen.cam.a...sens/manu21.pdf
3. de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJ, Stock G.
Time to talk SENS: critiquing the immutability of human aging.
Ann N Y Acad Sci. 2002 Apr;959:452-62; discussion 463-5.
PMID: 11976218 [PubMed - indexed for MEDLINE]
http://www.gen.cam.a...sens/manu12.pdf
4. de Grey AD, Campbell FC, Dokal I, Fairbairn LJ, Graham GJ, Jahoda CA, Porterg AC.
Total deletion of in vivo telomere elongation capacity: an ambitious but
possibly ultimate cure for all age-related human cancers.
Ann N Y Acad Sci. 2004 Jun;1019:147-70. Review.
PMID: 15247008 [PubMed - indexed for MEDLINE]
http://www.gen.cam.ac.uk/sens/WILT.pdf
