3 replies to this topic

[sonshoku]

HI! I am planning to use CDP-Choline together with Inositol for a couple of months. Is it safe/good to use CDP-choline everyday or is it a kind of supplement that should only be taken sometimes? And does inositol build tolerance?

Thanks

Edited by sonshoku, 07 August 2013 - 08:09 AM.

[gt35r]

What are your intention with CDP?

There is no good evidence that CDP long term is safer, good news is there is no real evidence to show thats it bad.

[mrd1]

'In studies where dopamine agonists are used, chronic injections (300mg/kg, but not 100mg/kg) are known to enhance apomorphine induced turning (42%).[79] This may be related to the dopamine transporter being upregulated by subchronic CDP-choline ingestion (cerebellum and frontal cortex)[75] which has been noted to occur in aged rats (11-18% with 100-500mg/kg CDP-Choline oral intake) over 7 months[70] " Examine

I purposely take CDP - Choline long term BECAUSE of the adaptions the brain makes to it.

CDP is just a prodrug of uridine (powerful antioxident) and choline. As long as you stay within the recommended safe choline intake I do not see how this would be harmful. However, I can find it very probable that it would be beneficial by causing a upregulation of dopmaine transporters which are commonly *burned off* aka adapation to things like massive sex drugs and food.


Inositol upregulates the d2 dopamine receptors which is believed to be one of the primary mediators of its effectiveness so I see no reason to believe that you get tolerant to it. If anything it gets more effective the longer you take it. http://www.ncbi.nlm....pubmed/11267629

As far as side effects as long as you dont go under the maximum recommended intake for choline and inositol I find it highly unlikely anything would happen to you and even doses much higher are probably safe

[Virtual Reality]

'In studies where dopamine agonists are used, chronic injections (300mg/kg, but not 100mg/kg) are known to enhance apomorphine induced turning (42%).[79] This may be related to the dopamine transporter being upregulated by subchronic CDP-choline ingestion (cerebellum and frontal cortex)[75] which has been noted to occur in aged rats (11-18% with 100-500mg/kg CDP-Choline oral intake) over 7 months[70] " Examine

I purposely take CDP - Choline long term BECAUSE of the adaptions the brain makes to it.

CDP is just a prodrug of uridine (powerful antioxident) and choline. As long as you stay within the recommended safe choline intake I do not see how this would be harmful. However, I can find it very probable that it would be beneficial by causing a upregulation of dopmaine transporters which are commonly *burned off* aka adapation to things like massive sex drugs and food.


Inositol upregulates the d2 dopamine receptors which is believed to be one of the primary mediators of its effectiveness so I see no reason to believe that you get tolerant to it. If anything it gets more effective the longer you take it. http://www.ncbi.nlm....pubmed/11267629

As far as side effects as long as you dont go under the maximum recommended intake for choline and inositol I find it highly unlikely anything would happen to you and even doses much higher are probably safe

Would the results be permanent in the dopamine receptors if you take inositol/and or cdp choline ?