When I developed a fatty liver due to some youthful lifestyle issues I pursued well into middle age, I tried de-ironing my body more out of desperation than belief it might actually fix what was ailing me. I had little to lose and was resistant to giving up the simple pleasures I loved. I was pretty aggressive and was donating blood and taking IP6 at the same time. My experience was generally good, though I did overshoot my goals and wound up a bit anemic for a month or so, but this resolved quite rapidly once I slacked off a bit. My iron wasn't even clinically high at the start of all this (ferritin around 160), but the upper limits for "normal" ferritin are truly set outrageously high, simply because elevated iron is so common in adult males. Youthful ferritin levels are well documented to average around 25 in menstruating females all the way up to menopause, with young men averaging slightly higher until they reach middle age, when iron starts climbing to stratospheric levels as we approach senior years (and diseases of all kinds start to pop-up!)
I chose Jarrow's IP6 simply because I had previous good experience with the brand, and at less than a dime a cap (500mg) I really didn't see a need to dig into the bargain bin. I've seen the prices of the IP6-Gold the cancer patients are flocking to and this looks like a rip-off to me. Inositol is as cheap as IP6 and the ratios aren't that hard to figure out and mix yourself. I also take Lecithin and eat eggs which are good sources of inositol so I didn't bother adding supplementary inositol, but stuck with simple IP6.
I've seen some thumping big doses of IP6 written about in the cancer forums (3 to 4 grams/day), but I never took more than 500mg/twice a day. The trick with IP6 is to take it on a very empty stomach with a full (8 oz) glass of water. For me this meant first thing in the morning and last thing before bed. When taken properly, a little IP6 goes a long way, but any food at all in your tum will neutralize much of the chelating effect. Fortunately, I found IP6 to be very easy on my empty stomach, though I always diluted it well with water. If you've had problems, you may have taken it with too little to drink.
I had almost no side effects early on when my iron was elevated, but noticed some dental sensitivities (to cold) after several months and started reducing my dosage (to 500mg/day) and cycling off it a couple days a week and this rapidly resolved. As I got my ferritin down around 20 (my initial target) and actually overshot this a bit (into the teens), I also noticed some afternoon fatigue and a soreness on the side of my tongue that would come and go as I cycled IP6. I did a bit of searching and found these are common symptoms with anemia and slacked off a bit with both the blood donation and IP6 and this too resolved very quickly.
Looking back, I was probably a bit too aggressive with my de-ironing... Chelation isn't the sort of thing you want to try and do fast. Slow and steady iron removal will give good results with less side effects and I'm a big believer in avoiding megadoses of any supplements, especially those that affect mineral balances.
I also supplemented LOW DOSE mag-citrate (100mg with lunch) and zinc (10mg also with lunch) during my aggressive chelation to insure these important min's didn't get low. I wasn't concerned with copper and calcium, as most folks are high in copper, and calcium is very abundant in my diet. I did add some high copper foods (seafood, chocolate, coffee & olives) on days I cycled off IP6 just to give copper a chance to catch up if by chance it was getting low.
The result? Well, the body will always tap stored iron in blood ferritin preferentially before it starts mining iron out of organs and tissue, so not much to report during the de-ironing process except the mild anemia I experienced donating blood and chelating at the same time. In the months that followed after I reached my target of ferritin 20, things started improving very nicely! Fatty liver? Gone! Documented by ultrasound. Fasting hypoglycemia? Gone! I could skip breakfast and work well past lunch without feeling like I was going to keel over. This would have been impossible for me just a couple years back.
Now that I'm thoroughly de-ironed, I've let my ferritin rise to 50, which is the sweet spot from what I've read. I feel 10 years younger, and yes, I'm still being a bit naughty with my lifestyle, but then I'm young again... Why not!
Edited by synesthesia, 22 September 2013 - 11:25 PM.