Hey guys,
so first of all, I wanted to say, that I've tried Amisulpride in the past for dysthymia, and it had no beneficial effect.
Also, I've tried amphetamines for ADHD. Unfortunately what they tend to do at this point is make me more stimulated but not more focused. It seems to even worsen OCD type symptoms and anxiety.
Now. I had this idea that perhaps if I took both at the same time, perhaps amisulpride would block the d2 and d3 receptors from being stimulated by the Amphetamine, which might account for the bad side effects, and that the D1 receptors, account for the good effects, would be stimulated by the amp.
Now, I know this is very simplistic , because in fact some people probably get good effects from d2 and d3 stimulation. Also D1 stimulation could actually hold problems for certain populations.
But I want to experiment. Before jumping into the water I just want to know if anyone has had similar experiences that I initially mentioned and has experience with trying both at the same time.
Also was wondering if anyone had knowledge on the pharmacology and biochemistry of this. For example does amisulpride block those d2 and d3 receptors strongly enough so that amphetamine wouldn't stimulate them? And what dosage would you need to take in order to do that? Amisulpride also blocks d1 receptors at a certain dose, so if you took Amphetamine with it , does amphetamine have a higher affinity for certain receptors over others?
And mostly i'm talking about dextroamphetamine here since that's what I'll be experimenting with.
Thanks in advance!
-Protoject