For thos of us who need to raise our HDL:
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Found this on Sci.life-extension:
J Lipid Res. 2005 Feb;46(2):350-5. Epub 2004 Dec 1. Related Articles,
Links
Phosphatidylinositol increases HDL-C levels in humans.
Burgess JW, Neville TA, Rouillard P, Harder Z, Beanlands DS, Sparks DL.
Liponex, Inc., Ottawa, Ontario, Canada, K2G 3R8.
Studies have shown that phosphatidylinositol (PI) can
stimulate reverse cholesterol transport by enhancing the flux of
cholesterol into HDL and by promoting the transport of high density
lipoprotein-cholesterol (HDL-C) to the liver and bile. The goal of this
study was to determine the safety and therapeutic value of PI after
oral administration to normolipidemic human subjects. We performed a
randomized 2 week study in 16 normolipidemic subjects. Subjects
received either 2.8 or 5.6 g of PI, with or without food. PI was well
tolerated by all subjects. PI significantly affected the levels of
HDL-C and triglyceride in the plasma of subjects receiving PI with
food. The lower dose showed a 13% increase in HDL-C, whereas the high
dose showed an increase of 18% over the 2 week period. Both low- and
high-dose groups showed significant increases in plasma apolipoprotein
A-I. The high dose of PI also decreased plasma triglycerides by 36% in
the fed subjects. These data suggest that after only 2 weeks, PI may
have a comparable therapeutic value to niacin, with negligible side
effects.
PMID: 15576836
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As far as I can tell it can be found in lecithin, but is not available seperately. In order to get as much as used in the study one would have to consume 4 or 8 tablespoons of lecithin.
Edit: actually about 2 or 4 tablespoons if you pick the right lecithin, still about 4 tablespoons for the 18% increase in HDL is a lot lof lecithin. Would be nice to find a better source.
Edited by scottl, 06 June 2005 - 04:24 AM.
