LONGECITY

Hey,

I'm sure someone has been through this before, anyone who has or is still taking adderall, how do you reduce tolerance? I hear magnesium before sleep and stuff. I'm on my first/second week of 10 mg of adderall. I already feel tolerance building up and 10mg will let me go for 2h constant concentration and then I just don't want to study any more.

Anyone know how to dose adderall to maximize it's benefits with any other compound and cycling schedule, any experience on the matter appreciated. Thanks!

Just don't want to go through a bunch of supp's that wont work for me.
Edited by yadayada, 20 November 2013 - 03:30 AM.

I know there are folks on this forum that know the answer to this so I'm bumping it too.

I have read in some forums that amantadine works, that works much better than memantine.

I took 30 mg of Adderall XR for 3 years and developed a tolerance in the second year.

To ensure adequate nutrition (while taking Adderall) I started having two eggs cooked in coconut oil for breakfast with the Adderall. Then I did about 15 minutes of HIIT. This food and exercise rekindled very close to the high energy euphoric state that I experienced in the first 3 months of taking Adderall, it also made the effects last longer throughout the day and eliminated most of the late afternoon and evening crash.

As long as I had that breakfast and did the short exercise the tolerance reduction was consistent. Without the exercise, the effect was still there, just not so strong.

I don't know why it worked so well, maybe because both the eggs and coconut oil are bases, thus helped sustain the Adderall longer, maybe also the choline in the eggs. Coconut oil alone actually has some pretty strong nootropic effects for me; high energy, clearer thinking, and better mood. I think the HIIT effect was enhanced by the food and the Adderall.

Magnesium is a key supplement when taking Adderall, IMO.

I found the only way to reduce tolerance is to take "drug holidays," or take a couple days off per week. Weekends are good for this. Also, never never never abuse the drug or take larger amounts than necessary. Sometimes it's tough when you've had a rough night's sleep, but I can promise you it will not help.

Use baking soda . It will alkalize your blood and you will be able to absorb more of the adderall. It works

Use baking soda . It will alkalize your blood and you will be able to absorb more of the adderall. It works

I once used a proton-pump inhibitor + dextroamphetamine.. and this was just not good. 10 mg of dex felt like being on 50 mg the usual way (too wired/speedy). so, one should be cautious doing this.

Has taking magnesium supplements worked for anyone? Just wondering. I'm on my fifth day of constant addy dosing and I feel tolerance creeping up. I took 15mg of Nardil today after about 2h into a total of 30mg of addy. Real bad hypertension and just feeling really wired. Thinking how else can I do with less adderall; but, still maintain that strong motivating effect.

I'm thinking of getting off Adderall after I read some reports on long term effects on synaptic plasticity and dopamine depletion as long as changes in brain morphology. Also, aortic dissection seems like a serious concern. Is Modafinil as good?

Drug tolerance is not the way we think it is, that is it is not your body getting building tolerance to the drug but your mind gets used to the drug as in there are no chemical reactions that happen to cause this mind-tolerance but just your mind.

Receptor downregulation is a common adaptive response of cells to repeated exposure to certain drugs or ligands. It is a mechanism by which cells attempt to maintain homeostasis in the face of prolonged stimulation. The downregulation of receptors can occur through several processes (Internalization, Desensitization, Downregulation of receptor synthesis [at the gene expression level]).

The downregulation of receptors serves as a negative feedback mechanism to counteract excessive or prolonged drug stimulation. But receptor downregulation isn't a universal response and can vary depending on the drug, specific receptor involved, and individual characteristics of the cells or tissues involved.

While receptor downregulation is a well-known mechanism contributing to drug tolerance, there are other possible sources as well. Here are some others:

1. Receptor desensitization: Repeated or prolonged exposure can cause receptors to become less responsive to the drug's binding, leading to a diminished effect. This occurs due to internalization of the receptors or through recruitment of regulatory proteins that dampen the signaling cascade.

2. Changes in intracellular signaling: Drug tolerance can arise from adaptations within the intracellular signaling pathways triggered by the drug. These changes may involve alterations in second messenger systems, downstream signaling molecules, or gene expression patterns that ultimately diminish the drug's effectiveness.

3. Upregulation of drug-metabolizing enzymes.

4. Induction of drug efflux transporters: Efflux transporters are proteins present on cell membranes that actively pump drugs out of cells. Prolonged drug exposure can induce the expression and activity of these transporters, leading to increased drug elimination from the target tissues, thereby reducing the drug's effectiveness.

5. Behavioral conditioning: Tolerance can also occur through a learned behavioral response. When a drug is repeatedly administered in the same environment or context, the body can anticipate the drug's effects and initiate compensatory mechanisms to counteract its actions irrespective of any significant physiological changes.

 

 

The exact mechanisms underlying Adderall tolerance are not fully understood, but several factors may contribute.

In addition to memantine and magnesium, other strategies include:

Taking periodic breaks from Adderall under medical supervision, commonly known as drug holidays. This approach involves temporarily discontinuing the medication or using it on an intermittent schedule.

Medication adjustments and Combination therapies. Switching to a different ADHD medication with a distinct mechanism of action can sometimes help. In some cases, combining Adderall with other medications, such as non-stimulant ADHD medications or adjunctive medications targeting specific symptoms, may help mitigate tolerance or enhance the therapeutic effects.

 

Selegiline, green tea, CBD (cannabidiol), and ginkgo have been suggested as potential options for managing ADHD symptoms, but it's important to note that the scientific evidence supporting their effectiveness in this context is limited and inconclusive.

 

Other options include elimination diets, omega-3s, mind-body techniques, and exercise routines.