17 replies to this topic

[unbreakable]

I know this is a controverse topic, nevertheless:

If we pretend just for a moment that more stem cells in the blood are helpful and that there exist no real risks with using supplements to achieve that... which supplements would you use?

I'll start with the usual suspects and hope you can add more:

Blueberry
Green Tea Extract
Carnosine
Vitamin D3

[hamishm00]

Fucoidan
Strontium
c60

[unbreakable]

Thanks!

What about Astragalus, Blue-Green Algae and Spirulina?

I forgot: Exists serious research on c60 or is pretty much useless?

[normalizing]

unbreakable, none of the ones you listed have any actual science backing them as being any significant, if possible, stem cell stimulators. except blue green algae which had some paper on it but it was very vague. i remember reading that there was too much impurities and toxins related to them, hence not worth the risk buying any. on the other hand hamishm00 is onto something with fucoidan

Edited by normalizing, 24 November 2013 - 06:01 AM.

[unbreakable]

Will such impurities also be in products of e.g. NOW foods?
I mean do they just test if there is too much mercury and so on in their products or also less known toxins?

Edited by unbreakable, 24 November 2013 - 06:49 AM.

[normalizing]

they are not required to do tests because nobody regulates the supplement industry. FDA only cares when people start sending complaints of a given supplement causing problems. its unregulated, huge business and i doubt the companies will waste money and time to send batches to tests. usually the companies selling the supplements are not their actual producers, but they buy the material in bulk from 3rd party synthesizying labs.

proceed with caution

[hav]

Not a supplement you can buy very easily, except maybe on the black market, but the number one stem cell stimulator is probably cord blood. Rumor has it that the China Cord Blood Corporation, one of the most actively traded stocks on the NYSE, might be behind the recent change in their country's one-baby policy:

http://www.stasiarep...nities-20131125

They are clearly marketing the service of facilitating folks banking their family cord blood. Which would be diabolical as a mandatory component of a family trust: getting kids and grandchildren to not only earn their inheritances, but help delay them into perpetuity for the benefit of elders. Royal families everywhere are probably jumping all over this. If the ethics don't bother you, no reason you could not do the same. Pretending of course that there are no real health risks.

Howard

[unbreakable]

Astragalus
Beta-Glucan
Blueberry Extract
Blue-Green Algae (Aphanizomenon Flos Aquae)
Carnosine
Colostrum
Cordyceps Sinensis
Ellagic Acid
Fo-Ti (Polygonum multiflorum)
Fucoidan
Glutamine
Goji (Lycium barbarum)
Lactobacillus fermentum (ImmuBlast)
Panax Ginseng
Placenta
Pterostilbene
Reishi
Spirulina
Strontium
Vitamin D3

G-CSF (Filgrastim)

[normalizing]

i would think you will link articles relating those to any stem cell production....

[Darryl]

There's a proprietary supplement Stem-Kine that purports to increase circulating stem cells.

Mikirova, Nina A., et al. "Circulating endothelial progenitor cells: a new approach to anti-aging medicine?." Journal of translational medicine 7.1 (2009): 106.
Mikirova, Nina A., et al. "Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects." Journal of translational medicine 8.1 (2010): 34.

The nutritional supplement Stem-Kine (Aidan Products, Chandler, AZ) contains: ellagic acid a polyphenol antioxidant found in numerous vegetables and fruits; vitamin D3 which has been shown to mildly increase circulating progenitor cells; beta 1,3 glucan (previous studies have reported administration of various beta glucans to elicit stem cell mobilization, and a ferment of the bacterium, Lactobacillus fermentum. Lactobacillus fermentum is generally regarded as safe, and has been in the food supply for hundreds of years as a starter culture for the production of sour dough bread and provides for its characteristic sour flavor. Extract of green tea, extract of goji berries, and extract of the root of astragalus were added prior to the fermentation process. Green tea extracts and some components of goji berries are known to mildly stimulate progenitor cell release, and astragalosides and other molecules found in the root of astragalus are known antioxidants that can prevent cellular damage secondary to oxidation.

StemTech HealthSciences has a number of products (including one for pets!) sold via multi level marketing. Major ingredients include the cyanobacteria Aphanizomenon flos-aquae, seaweed Undaria pinnatida (wakame), and fungus Ophiocordyceps sinensis. The major paper appears to be:

Jensen, Gitte S., et al. "Mobilization of human CD34+ CD133+ and CD34+ CD133-stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae--related to modulation of CXCR4 expression by an L-selectin ligand?." Cardiovascular Revascularization Medicine 8.3 (2007): 189-202.

Natura Therapeutics is yet another company offering snak....stem cell supplements. Their formula appears to be blueberry & green tea extracts, catechin, carnosine, and vitamin D, as detailed in this paper:

Bickford, Paula C., et al. "Nutraceuticals synergistically promote proliferation of human stem cells." Stem cells and development 15.1 (2006): 118-123.

I'm a bit dubious about the polyphenols in these supplements (in vivo redox cycling is a pretty scattershot way of modulating cell function), but vitamin D and beta-glucans (also in the Cordiceps) are pretty fascinating pluripotent compounds. At any rate, there are plenty of subjects for further research.

Edited by Darryl, 08 December 2013 - 09:02 AM.

[unbreakable]

Here is a LEF article with details about the study with blueberry, green tea, carnosine and vitamin D: http://www.lef.org/m...006_awsi_01.htm

Stem cell mobilization with G-CSF (Filgrastim) seems to be an interesting topic:http://www.ncbi.nlm....pubmed/16936417

G-CSF improves the clinical signs and symptoms of patients with intractable peripheral artery disease to the same degree as bone marrow transplantation does. This noninvasive treatment may thus represent a useful new approach to managing the disease.

In case of intractable disease a combo of blueberry extract, green tea, carnosine, vitamin D, fucoidan + subcutane Filgrastim might be worth a shot.

Edited by unbreakable, 08 December 2013 - 09:36 AM.

[Next]

Anybody experiment with "stem cell" supplements for topical use? I feel that my skin appears more vibrant but that could be due to the other ingredients I suppose.

[unbreakable]

Some supplements like fucoidan might increase CD34 cell count, but I don't think topical products are of much use.

What are the ingredients?

P.S.: I think beta 1,3/1,6 glucan is a good substitute for Cordyceps with regards to stem cell mobilization.

Edited by unbreakable, 14 December 2013 - 07:27 AM.

[unbreakable]

Food supplement 20070721-GX may increase CD34+ stem cells and telomerase activity.

Few rejuvenation and antiaging markers are used to evaluate food supplements. We measured three markers in peripheral blood to evaluate the antiaging effects of a food supplement containing placental extract. Samples were evaluated for CD34(+) cells, insulin-like growth factor 1 (IGF1), and telomerase activity, which are all markers related to aging. To control the quality of this food supplement, five active components were monitored. In total, we examined 44 individuals who took the food supplement from 1.2 months to 23 months; the average number of CD34(+) cells was almost 6-fold higher in the experimental group compared with the control group. Food supplement intake did not change serum IGF1 levels significantly. Finally, the average telomerase activity was 30% higher in the subjects taking this food supplement. In summary, our results suggest that the placental extract in the food supplement might contribute to rejuvenation and antiaging.

http://www.ncbi.nlm....pubmed/22577293
http://www.hindawi.c...ri/2012/498051/ (full)

This is the product: http://goo.gl/BvWfSY (No, I don't sell it...)

Ingredients: Sheep Placenta Powder, Avocado oil, Wheat germ oil, Royal jelly.

Edited by unbreakable, 14 December 2013 - 12:02 PM.

[Hebbeh]

mmmm......sheep placenta. Visit any sheep rancher in the spring of the year and I'm sure you can pick up all you want for free.

[normalizing]

lol who would consume sheep placenta ? is there even any biochemical analyses of what it contains ? sick

[unbreakable]

Fucoidan
Strontium
c60

I read some studies about strontium and stem cells, does it "just" help with bone health?

[unbreakable]

Some popular drugs - like NSAIDs, lithium (carbonate) and statins - might also be useful for stem cell mobilization:



http://www.nature.co...m-cells-1.12600
http://www.ncbi.nlm....les/PMC3606692/
https://ash.confex.c...Paper34836.html


Lithium:

http://onlinelibrary...998.00537.x/pdf
http://www.jci.org/a...sd/pdf/render/1
http://www.jleukbio....nt/85/1/20.full

Statins:

http://circ.ahajourn...03/24/2885.long
http://circ.ahajourn...bstracts/A12837
http://www.ncbi.nlm....pubmed/19754853