2 replies to this topic

[knackers323]

For those that understand the alternate view on the reason antidepressants work, can they please explain it to me.

And explain why I have tried about ten ssri s but only paroxetine and citilopram work? If it is a problem of lack of serotonin, shouldn't all ssri s work?

What do aropax and citilopram have in common?

Thanks very much

[Comblop]

Your genetics play a large part in whether a certain antidepressant will work or not. Certain genetic markers mean certain antidepressants cross the Blood-Brain-Barrier much easier, increasing the probability that you will respond favorably.

In this study, researchers examined 435 people who had been diagnosed with depression and treated with different anti-depressants. Of the 435, 133 were prescribed one of four common antidepressants – amitriptyline (Elavil), paroxetine (Paxil), venlafaxine (Effexor) and citalopram (Celexa). Researchers found two SNPs in the gene ABCB1, including rs2032583, that were significantly associated with the likelihood that a person would experience a remission of depression symptoms after taking one of those four antidepressants; the drugs were more likely to be effective among people with at least one G at rs2032583. The effect may be due to the fact that ABCB1 encodes a protein that is involved in ferrying substances across the blood-brain barrier, which protects the central nervous system from potentially dangerous substances in the rest of the body.

http://www.ncbi.nlm....h&term=18215618

[knackers323]

Wow comblop, thanks for the reply. I had no idea about this. Do you know if this is the only reason why they think some work and others don't?

And I don't suppose you know if aropax and citilopram generally both seem to work for the same person?

Thanks